个人简介
 

个人简历:

 

2005年至今:浙江大学药学院光彪讲座教授

 

2004-2006:浙江大学药学院访问教授

 

1990-2008:美因兹大学药学院生物制药系主任,C4教授

 

1987-1989:慕尼黑大学化学与药学学院教授

 

1981-1986:慕尼黑大学化学与药学学院副教授

 

1980:慕尼黑大学化学与药学学院生物制药研究所交换学者

 

1979:波鸿大学生物系助理教授

 

1978:普渡大学药学院访问学者

 

1977:德州农工大学化学系访问学者

 

1971-1977:波鸿大学生物系助理研究员

 

1968-1971:明斯特大学博士(有机化学专业)

 

1968:基尔大学硕士

 

1963-1968:基尔大学化学系本科

   

Stöckigt教授发表的代表性论文:

2009

1. Liuqing Yang, Marco Hill, Meitian Wang, Santosh Panjikar, and Joachim Stoeckigt: Structural basis and enzymatic mechanism of the biosynthesis of C9- from C10- Monoterpenoid indole alkaloids. Angew. Chem. (Intern. Ed.), 48, 5211-5213 (2009).

2. Stöckigt, J., Hammes, B., Ruppert, M.: Construction and expression of a dual vector for chemo-enzymatic synthesis of plant indole alkaloids in Escherichia coli. Nat. Prod. Res., in press (2009)

3. Stöckigt, J.: The Alkaloidal Metabolome, Proteome and Crystallome of the Tropical Plant Rauvolfia. In: Proceedings of the 12 th Asian Symposium on Medicinal Plants, Species and other Natural Products (ASOMPS XII), (2008), Padang (Indonesia), in press (2009).

4. Stöckigt, J., Barleben, L., Ruppert, M., Hill, M.: Alkaloid Biosynthesis in the Indian Medicinal Plant Sarpagandha. In: Proceedings of the "2nd International Conference on Heterocyclic Chemistry", Jaipur ( India), in press (2009).

5. Hongbin Zou, Liang Zhang, Lei Xiang Yang, Liu Qing Yang, Yu Zhao, Yong Ping Yu, Joachim Stöckigt: Synthesis and structure-activity relationship studies of cytotoxic cinnamic alcohol derivatives. Nat. Prod. Res., in press (2009).

6. Xiaoyu Wang, Lianli Sun, Kexin Huang, Shuyun Shi, Lijuan Zhang, Juanhua Xu, Hua Peng, Xianfeng Sun, Liwei Wang, Xiumei Wu, Yu Zhao, Xiaokun Li, Joachim Stöckigt, Jia Qu: Phytochemical investigation and cytotoxic evaluation of the components of the medicinal plant Ligularia atroviolacea. Chemistry & Biodiversity, 6(7), 1053-1065 (2009). 

 

2008

1. Barleben, L., Stöckigt, J.: Indole Alkaloid Biosynthesis: The Pathways leading to Ajmalicine and Ajmaline. Science and Culture, 74, 71-76 (2008). 

2. Sun, L., Ruppert, M., Sheludko, Y., Warzecha, H., Zhao, Y., Stöckigt, J.: Purification, Cloning, Functional Expression and Characterization of Perakine Reductase – the First Example from the AKR Enzyme Family Specifically Extending the Alkaloidal Network of the Plant Rauvolfia. Plant Mol. Biol., 67, 455-467 (2008). 

3. Maresh, J., Giddings, L., Friedrich, A., Loris, E., Panjikar, S., Trout, B., Stöckigt, J., Peters B., O’Connor, S.: Strictosidine Synthase: Mechanism of a Pictet-Spengler Catalyzing Enzyme. J. Am. Chem. Soc., 130, 710-723 (2008). 

4. Stöckigt, J., Barleben, L., Panjikar, S., Loris, E.: 3D-Structure and Function of Strictosidine Synthase – the Key Enzyme of Monoterpenoid Indole Alkaloid Biosynthesis. Plant. Physiol. Biochem., 46, 340-355 (2008). 

5. Shi, S., Hu, M., Wu, D., Zhou, C., Mo, J., Xu, J., Chen, L., Dou, H., Peng, H., Hao, X., Stöckigt, J., Zhao, Y.: A new dibenzofuran and other constituents from Ligularia caloxantha, a Chinese medicinal plant. Nat. Prod. Res., 22, 628-632 (2008). 

6. Tao, Q., Xu, Y., Lam, R., Schneider, B., Dou, H., Leung, P., Shi, S., Zhou, C., Yang, L., Zhang, R., Xiao, Y., Wu, X., Stöckigt, J., Zeng, S., Cheng, C., Zhao, Y.: Diarylheptanoids and a Monoterpenoid from the Rhizomes of Zingiber officinale: Antioxidant and Cytoprotective Properties. J. Nat. Prod., 71, 12-17 (2008).

 

2007

1. Stöckigt, J., Panjikar, S.: Structural Biology in Plant Natural Product Biosynthesis -  Architecture of Enzymes from Monoterpenoid Indole and Tropane Alkaloid Biosynthesis. Nat. Prod. Rep., 24, 1382-1400 (2007).

2. Barleben, L., Panjikar, S., Ruppert, M., Koepke, J., Stöckigt, J.: Molecular Architecture of Strictosidine Glucosidase: The Gateway to the Biosynthesis of the Monoterpenoid Indole Alkaloid Family. Plant Cell., 19, 2886-2897 (2007).

3. Loris, E., Panjikar, S., Ruppert, M., Barleben, L., Unger, M., Schubel, H., Stöckigt, J.: Structure-Based Engineering of Strictosidine Synthase: Auxiliary for Alkaloid Libraries. Chem. Biol., 14, 979-985 (2007).

4. Wang, F., Yang, L., Huang, K., Li, X., Hao, X., Stöckigt, J., Zhao, Y.: Preparation of Ferulic Acid Derivatives and Evaluation of their Xanthine Oxidase Inhibition Activity. Nat. Prod. Res., 21, 196-202 (2007).

5. Stöckigt, J., Panjikar, S., Ruppert, M., Barleben, L., Ma, X. Loris, E., Hill, M.: The molecular architecture of major enzymes from ajmaline biosynthetic pathway. Phytochem. Rev., 6, 15-34 (2007).

 

2006

1. Rosenthal, C., Mueller, U., Panjikar, S., Sun, L., Ruppert, M., Zhao., Y., Stöckigt, J.: Expression, purification, crystallization and preliminary X-ray analysis of perakine reductase, a new member of the aldo-keto reductase enzyme superfamily from higher plants. Acta Cryst. F., 62, 1286-1289 (2006).

2. Ma, X., Panjikar, S., Koepke, J., Loris, E., Stöckigt, J.: The structure of Rauvolfia serpentina strictosidine synthase is a novel six-bladed beta-propeller fold in plant proteins. Plant Cell, 18, 907-920 (2006).

3. Ruppert, M., Panjikar, S., Barleben, L., Stoeckigt, J.: Heterologous expression, purification, crystallization and preliminary X-ray analysis of raucaffricine glucosidase – a plant enzyme specifically involved in Rauvolfia alkaloid biosynthesis. Acta Cryst. F., 62, 257-260 (2006).

4. Wang, F., Jiang, X., Hu, L., Dong, S., Wu, X., Bai, H., Zhang, Y., Stöckigt, J., Zhao, Y.: A Novel and Convenient Method for the Synthesis of Ubiquinone-10. Lett. Org. Chem., 3, 610-612 (2006). 

5. Feng, J.H., Ding, H.X., Xiong, Y., Pan, Y.J., Zhang, Y.M., Hao, X.J., Guéritte, F., Stöckigt, J., Zhao, Y.: Synthesis of Novel Unsaturated Alkyl Ethers of Racemic Deoxyisopodophyllotoxin as Cytotoxic Agents. Chin. Chem. Lett., 17, 863-866 (2006). 

6. Zhao, Y., Feng, J., Ding, H., Xiong, Y., Zheng, Q., Fan, B., Zhang, Y., Hao, X., Wu, Guéritte, F., Stöckigt, J.: Synthesis and Cytotoxicity Evaluation of Novel Derivatives of 4-Deoxyisopodophyllotoxin. J. Nat. Prod., 69, 1145-1152 (2006). 

7. Gong, J., Weng, L., Wang, F., Feng, Y., Zhou, C., Li, H., Wu, Y., Hao, X., Wu, X., Bai, H., Stöckigt, J., Zhao, Y.: Synthesis and Antioxidant Properties of Novel Silybin Analogues. Chin. Chem. Lett., 17, 465-468 (2006). 

8. Yang, L., Gong, J., Wang, F., Zhang, Y., Wang, Y., Hao, X., Wu, X., Bai, H., Stöckigt, J., Zhao, Y.: Synthesis and Antioxidant Properties Evaluation of Novel Silybin Analogue. J. Enz. Inhib. Med. Chem., 21, 399-404 (2006). 

9. Gong, J., Feng, Y., Wang, F., Zhou, C., Li, H., Wu, Y., Hao, X., Wu, X., Bai, H., Stöckigt, J., Zhao, Y.: Preparation of ( ± )-5,6,7-Tri-oxygenated Dihydroflavonols and Evaluation of Their Inhibitory Bioactivities on HSV-1. Chin. Chem. Lett., 17, 449-452 (2006).

10. Hongbin Zou, Shengyi Dong, Changxin Zhou, Lihong Hu, Yihang Wu, Haibo Li, Jingxu Gong, Lianli Sun, Xiumei Wu, Hua Bai, Botao Fan, Xiaojiang Hao, Joachim Stöckigt, Yu Zhao: Design, Synthesis and SAR Analysis of Cytotoxic Sinapyl Alcohol Derivatives. Bioorganic & Medicinal Chemistry, 14, 2060-2071 (2006).

 

2005

1. Ruppert, M., Woll, J., Giritch, A., Genady, E., Ma, X., Stöckigt, J.: Functional expression of an ajmaline pathway-specific esterase from Rauvolfia in a novel plant-virus expression system. Planta, 222, 888-898 (2005).

2. Ruppert, M., Ma, X., Stöckigt, J.: Alkaloid Biosynthesis in Rauvolfia - cDNA Cloning of major Enzymes of the Ajmaline Pathway"; thematic issue "Recent Progress in Alkaloid Chemistry. Current Organic Chemistry, 9, 1431-1444 (2005).

3. Ma, X., Koepke, J., Panjikar, S., Fritzsch, G., Stöckigt, J.: Crystal structure of vinorine synthase, the first represantative of the BAHD superfamily. J. Biol. Chem., 280, 13576-13583 (2005).

4. Ma, X., Koepke, J., Bayer, A., Fritzsch, G., Michel, H., Stöckigt, J.: Crystallization and Preliminary X-ray Analysis of native and Selenomethionyl Vinorine Synthase from Rauvolfia serpentina. Acta Crystallogr. Sect. D., 61, 694-696 (2005).

5. Koepke, J., Ma, X., Fritzsch, G., Michel, H., Stöckigt, J.: Crystallization and Preliminary X-ray Analysis of Strictosidine Synthase and its Complex with the Substrate Tryptamine. Acta Crystallogr. Sect. D., 61, 690-693 (2005).

6. Barleben, L., Ma, X., Koepke, J., Peng, G., Michel, H., Stöckigt, J.: Expression, purification, crystallization and preliminary X-ray analysis of strictosidine glucosidase, an enzyme initiating biosynthetic pathways to a unique diversity of indole alkaloid skeletons. Biochim. Biophys. Acta, 1747, 89-92 (2005).

 

2004

1. Zhao, Y., Yu, R.-M., Schroeder, C., Sadler, I., Unger, M., Sun, X.-F., Rankin, D.W.H., Stöckigt, J.: Biotransformation of Paclitaxel (Taxol®) by the Cell Suspension Cultures of Rauvolfia serpentina. Acta Botanica Sinica, 46, 1383-1386 (2004).

2. Ma, X., Koepke, J., Bayer, A., Linhard, V., Fritzsch, G., Zhang, B., Michel, H.,Stöckigt, J.: Vinorine synthase from Rauvolfia – the first example of crystallization and preliminary X-ray diffraction analysis of an enzyme of the BAHD superfamily. Biochimica et Biophysica Acta, 1701, 129-132 (2004).

3. Ma, X., Koepke, J., Fritzsch, G., Diem, R., Kutchan, Toni M., Michel, H., Stöckigt, J.: Crystallization and Preliminary X-ray Crystallographic Analysis of Strictosidine Synthase from Rauvolfia – the First Member of a Novel Enzyme Family. Biochim. Biophys. Acta, 1702, 121-124 (2004).

4. Fei, X., Hill, M., Ma, X., Teng, L., Li, Q., Stöckigt, J.: Isolation of a Putative Ribosome Inactivating Protein from Dried Roots of Trichosanthes kirilowii used in Traditional Chinese Medicine. Planta Medica, 70, 364-365 (2004).

5. Bayer, A., Ma, X., Stöckigt, J.: Acetyltransfer in natural product biosynthesis - functional cloning and molecular analysis of vinorine synthase. Bioorg. Med. Chem., 12, 2787-2795 (2004).

6. Gerasimenko, I., Ma, X., Sheludko, Y., Mentele, R., Lottspeich, F., Stöckigt, J.: Purification and partial amino acid sequences of the enzyme vinorine synthase involved in a crucial step of ajmaline biosynthesis. Bioorg. Med. Chem., 12, 2781-2786 (2004).

工作研究领域

1. 药用植物的生物技术研究与应用 2. 活性天然产物的生物合成与酶化学合成 3. 结构、计算与合成生物学研究

联系方式

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