个人简介

高长有 教授 博士 杰青 长江特聘教授

浙江大学生物医用大分子研究所
浙江大学高分子科学与工程学系 杭州310027,
电话: +86-571-87951108
传真: +86-571-87951108
Email: cygao@mail.hz.zj.cn
        cygao@zju.edu.cn 

课题组主页:http://polymer.zju.edu.cn/biomaterials/Chinese/

      高长有,男,1966生于吉林辉南。1986-1996年,在吉林大学化学系学习,获得高分子化学与物理博士学位。1996-1998在浙江大学高分子系做博士后。2001起任职教授;2002年起为博士生导师。1999年至今,作为高访学者每年在德国马普胶体与界面研究所进行合作研究2-3个月。
      主要研究方向是生物医用高分子,是材料学、化学与生命科学高度交叉的前沿研究领域。具体包括:组织工程与再生医学材料、纳米与胶体生物材料及其与细胞的相互作用。指导思想是采用材料和化学的手段和技术解决组织修复和再生的基础和应用问题,提供用于皮肤、软骨、骨和肝等治疗的材料与技术。

课题组主要研究方向:

(1) 组织修复与再生医用高分子材料
(2) 细胞迁移与分化诱导材料
(3) 纳米和胶体微粒与细胞的相互作用
(4) 自组装微胶囊及其他新结构胶体和纳米材料

      在聚合物中空微胶囊的制备与性能研究方面取得了国际先进,在某些方面领先的成果;在组织工程支架的制备与表面相容性构建方面取得了创新性的研究成果。例如,解决了高完好率自组装聚电解质中空微胶囊的制备问题,获得了热和离子强度敏感的智能微胶囊;建立了基于连续介质理论和渗透压法测定纳米超薄膜机械强度方法,最先报道了聚电介质纳米超薄膜的弹性模量;发现了微胶囊热致尺寸变化现象;最早发现水溶性物质在微胶囊中的自沉积现象,并成功地用于酶、蛋白和药物(抗癌药)的包埋;较早建立了热致相分离技术制备聚合物组织工程支架的普适方法,制备了特定微结构的用于组织工程化软骨、皮肤和血管的多孔支架;较早报道了组织工程材料表面胺解、紫外光氧化接枝进而固定生物活性因子的新方法,及其有效促进软骨、成纤维和内皮细胞的生长作用。

       作为负责人先后承担国家自然科学基金面上项目5项,国家杰出青年科学基金1项,国家自然科学基金重点项目2项,国家自然科学基金重大国际合作项目1项,生物材料973计划课题2项,参与973计划“组织工程的基本科学问题”研究。在Angewandte Chemie、Advanced Materials、Chemical Communications、Chemistry, a European Journal、Chemistry of Materials、Macromolecules、Journal of Physical Chemistry B、Biomacromolecules、Biomaterials和Tissue Engineering等本学科国内外核心期刊发表SCI收录论文200余篇。多次参加国内外相关领域的学术会议并做邀请报告。编著有《医用生物材料》,参与撰写和编著专著多部。国家授权发明专利40余项。获2003年度浙江省首届优秀博士后;浙江省科技奖1等和2等各一项(2008、2010);2003年度浙江省高等学校科研成果奖一等奖1项;浙江省151人才二层次入选者;国家杰出青年基金获得者;教育部长江特聘教授。现为中国生物材料学位理事,中国生物医学工程委员会生物材料分会、组织工程分会委员,中国复合材料学会生物复合材料专业委员会委员;《科学通报》、《中国科学B:化学》、《Journal of Zhejiang University》、《组织工程与重建外科》、《Journal of Nanoscience Letters》、 《Colloids and Surfaces B: Biointerfaces》 、《化学进展》、《TheScientificWorldJOURNAL》、《Chinese Journal of Polymer Science》等杂志编委。 课题组已先后培养博士和硕士各25名;当前在读博士和硕士研究生20余名。




Changyou Gao, Prof. Dr.
Department of Polymer Science and Engineering,
College of Materials Science and Chemical Engineering,
Zhejiang University, Hangzhou 310027,China 

Tel: +86-571-87951108
Fax: +86-571-87951108
Email: cygao@mail.hz.zj.cncygao@zju.edu.cn

Education:
Ph.D. of Polymer Chemistry and Physics, Jilin University. China, July, 1996
Thesis: Molecule Design and Syntheses of High Performance Optical Resins
M.S. of Polymer Chemistry and Physics, Jilin University, China, July, 1993
Thesis: Preparation and Characterization of Organo-silicone Abrasion-resistant Films
Bachelor of Polymer Materials, Jilin University. China, July, 1990
Thesis: Interpenetrating Polymer Network of Polyurethanes/Polyacrylates/Epoxy Resins

Working Experience:
Dec. 2001-present, Professor of Materials Science, Department of Polymer Science and Engineering, Zhejiang University
July 1998-Dec. 2001, Associate professor of Materials Science, Department of Polymer Science and Engineering, Zhejiang University
Sep. 1996-Sep. 1998, Post doctor fellowship of polymer materials, Department of Polymer Science and Engineering, Zhejiang University
Oct. 1999-Nov. 1999, Deutscher Akademischer Austauschdienst (DAAD) fellowship, Germany
1999-present    Visiting professor to Max-Planck-Institute of Colloids and Interfaces, Germany, 2-3 months per year.

Research Fields
1.Biointerfaces of polymeric materials and biological system. Aiming at modulating the response of biological system to the synthetic polymeric materials, surface engineering of the materials are being systematically investigated by advanced technologies such as confocal laser scanning microscopy, scanning force microscopy, scanning and transmission electron microscopy, fluorescence spectroscopy, infrared spectroscopy, and cell culture in vitro. Several novel techniques have been developed to incorporate biological molecules into the synthetic materials’ surfaces to obtain hybrids, such as photo-oxidation and photo-induced grafting, controllable aminolysis and layer-by-layer assembly etc.

2.Tissue engineering and tissue engineering materials. The regeneration of damaged or defected tissues by a tissue engineering way is very promising since this allows the recovery not only the macroscopic contours and functions, but also the micro-structure and normal response of natural tissues. Construction of tissue-engineered organs relies on the biodegradable scaffolds, seed cells, and the combination of them. Several methods have been developed to fabricate porous polymeric scaffolds with controllable microstructure, including thermally induced phase separation, and paraffin sphere leaching. The microstructure such as the pore size, porosity, pore shape and interconnectivity of the pores is well modulated by fabricating conditions. Specially tailored conditions can generate pores ranging from micrometers to hundreds of micrometers. Seeding mammalian cells such as fibroblasts, chondrocytes and endothelial cells into the scaffolds have obtained hybrids of materials and cells, which are promising candidates for regeneration of the corresponding organs, e.g. skin, cartilage and blood vessel.

3.Layer-by-layer assembly and hollow capsules. The integrity of the hollow capsules fabricated by layer-by-layer assembly on sacrificial cores and removal of the cores influences greatly the properties which are crucial for the subsequent studies. The fabrication of the hollow capsules has been well investigated with respect to the quality of the capsules, resulting in >90% of intact capsules at the optimal conditions. The mechanical property of the hollow capsules was firstly explored by osmotic induced capsule deformation, yielding the elasticity of the LBL multilayers constituting the capsule wall. The Surface texture of capsules and the thermally and salt induced capsule shrinking and swelling were found, and the inherent mechanism was discussed. A surprising phenomenon for the capsules was revealed that could spontaneously deposit many water soluble substances into the capsules at mild conditions. The deposition amount was quantified. Subsequent sustained release of the deposited substances was followed; the released anti-cancer drugs retained the function to induce cell apoptosis. A smarter encapsulation and release is under investigation by using pH or thermal sensitive polymers.
Many national grants have been approved to support the above research, including the Natural Science Foundation of China (3 projects, principle investigator), Extinguished Young Scientist Award (principle investigator) and Key project from the Natural Science Foundation of China (principle investigator), and Basic Research Program of China (973 project, co-investigator).
More than 100 peer-reviewed scientific papers, 1 book-chapter, and 8 authorized patents have been published. Being a referee for several peer-reviewed academic journals such as Journal of American Chemical Society, Advanced Materials, Chemistry of Materials, Langmuir, Macromolecules, Polymer, Tissue Engineering, Biomacromolecules, Biomaterials, Macromolecular Bioscience, Macromolecular Rapid Communications, Colloids and Surface A, Journal of Applied Polymer Science, Polymer International etc, and for the National Natural Science Foundation of China, the Doctoral Foundation of Education Ministry of China, and the Young Teacher Award of Chinese Universities.

工作研究领域

生物材料的表面与界面、聚合物组织工程材料(如皮肤和软骨)、聚合物中空微胶囊(基础研究与药物控释)、表面图案化和纳米生物材料等. Surface and Interface of Biomaterials, Biomaterials for Tissue Engineering and Regenerative Medicine, Polymeric Hollow Microcapsules, Surface Patterning, and Nanobiomaterials.

联系方式

电话:+86-571-87951108
电子信箱:cygao@zju.edu.cn