个人简介

陈光弟,博士、教授、博士生导师。2002年毕业于浙江大学医学院获预防医学专业学士学位;2007年毕业于浙江大学医学院获博士学位,从事电磁场的生物学效应研究;2007-2011年于加拿大UBC医学院从事临床肿瘤学方向的博士后研究;2011年3月起,受聘浙江大学医学部,从事环境医学、肿瘤生物学和职业病学研究。研究成果以第一作者和通讯作者身份发表于Oncogene、JID等SCI收录的Top期刊杂志论文20余篇;主持国家自然科学基金项目3项、省部级科研项目多项。

工作研究领域

1. 环境医学:环境污染(包括物理因素和化学因素)的生物学效应研究及健康风险评估。 2. 职业医学:职业性危害因素的控制评价,职业病和中毒的干预措施研究。 3. 肿瘤生物学:肿瘤标志物的筛选及其应用研究。
代表性论文
1. Jing Guo, Liling Su, Xinyuan Zhao, Zhengping Xu, Guangdi Chen*. Relationships between urinary antimony levels and both mortalities and prevalence of cancers and heart diseases in general US population, NHANES 1999-2010. Sci Total Environ. 2016 Jul 8. [Epub ahead of print] PMID: 27396316
2. Liling Su, Yue Fei, Xiaoxia Wei, Jing Guo, Xiangen Jiang*, Liqin Lu*, Guangdi Chen*. Associations of parental occupational exposure to extremely low-frequency magnetic fields with childhood leukemia risk. Leuk Lymphoma. 2016 Apr 7: 1-8. [Epub ahead of print] (*Co-corresponding Authors) PMID: 27054704
3. Dongyu Li, Xinyuan Zhao, Wei Qin, Hequn Zhang, Yue Fei, Liwei Liu, Ken-Tye Yong, Guangdi Chen*, Ben Zhong Tang*, Jun Qian*. Toxicity assessment and long-term three-photonfluorescence imaging of bright aggregation-inducedemission nanodots in zebrafish. Nano Research 2016, 9(7): 1921-1933. (*Co-corresponding Authors)
4. Li Jiang, Xinyuan Zhao, Yue Fei, Dongdong Yu, Jun Qian, Jinguang Tong, Guangdi Chen*, Sailing He*. The effects of magnetic fields exposure on relative permittivity of saline solutions measured by a high resolution SPR system.Sci Rep. 2016 Apr 28; 6: 25111. (*Co-corresponding Authors) PMID: 27121618
5. Rongpan Bai, Chunhua Weng, Haojie Dong, Siqi Li, Guangdi Chen*, Zhengping Xu*. MicroRNA-409-3p suppresses colorectal cancer invasion and metastasis partly by targeting GAB1 expression. Int J Cancer. 2015 Nov 15; 137(10): 2310-22. (*Co-corresponding Authors) PMID: 25991585
6. Yongdui Chen, Siqi Li, Liling Su, Jinghao Sheng, Wen Lv, Guangdi Chen*, Zhengping Xu*. Association of progranulin polymorphism rs5848 with neurodegenerative diseases: a meta-analysis. J Neurol. 2015 Apr;262(4):814-22. (*Co-corresponding Authors) PMID: 25578179
7. Jinghao Sheng, Liling Su, Zhengping Xu, Guangdi Chen*. Progranulin polymorphism rs5848 is associated with increased risk of Alzheimer's disease. Gene. 2014, 542(2):141-5. PMID: 24680777
8. Meibian Zhang, Xinglin Fang, Lifang Zhou, Liling Su, Jiajia Zheng,Minjuan Jin, Hua Zou*, Guangdi Chen*. Pesticide poisoning in Zhejiang, China: a retrospective analysis of adult cases registration by occupational disease surveillance and reporting systems from 2006 to 2010. BMJ Open 2013; 3: e003510. (*Co-corresponding Authors) PMID: 24270833
9. Guangdi Chen, Yabin Cheng, Yun Tang, Magda Martinka, Gang Li*. Role of Tip60 in Human Melanoma Cell Migration, Metastasis, and Patient Survival. J Invest Dermatol. 2012 Nov; 132 (11): 2632-2641. PMID: 22673729
10. Guangdi Chen, Deqiang Lu, Huai Chiang, Dariusz Leszczynski D, Zhengping Xu*. Using model organism Saccharomyces cerevisiae to evaluate the effects of ELF-MF and RF-EMF exposure on global gene expression. Bioelectromagnetics. 2012 Oct; 33 (7): 550-560. PMID: 22487891.
11. Guangdi Chen, Yabin Cheng, Zhizhong Zhang, Magdalena Martinka, Gang Li*. Prognostic significance of cytoplasmic p27 expression in human melanoma. Cancer Epidemiol Biomarkers Prev. 2011 Oct; 20(10): 2212-2221. PMID: 21828232
12. Guangdi Chen, Yabin Cheng, Magdalena Martinka, Gang Li*. Cytoplasmic Skp2 Expression Is Increased in Human Melanoma and Correlated with Patient Survival. Plos One. 2011 Feb; 6(2):e17578. PMID:21386910
13. Guangdi Chen, Yabin Cheng, Magdalena Martinka, Gang Li*. Cul1 expression is increased in early stages of human melanoma. Pigment Cell Melanoma Res. 2010 Aug; 23 (4): 572-574. PMID: 20518860
14. Guangdi Chen, Gang Li*. Increased Cul1 expression promotes melanoma cell proliferation through regulating p27 expression. Int J Oncol. 2010 Nov; 37(5):1339-1344. PMID: 20878082
15. Guangdi Chen#, Yemin Wang#, Marco Garate, Jianwei Zhou, Gang Li*. The tumor suppressor ING3 is degraded by SCF (Skp2)-mediated ubiquitin-proteasome system. Oncogene. 2010 Mar; 29(10):1498-1508. (# Co-first authors) PMID: 19935701
16. Qunli Zeng#, Guangdi Chen#, Yu Weng, Lingli Wang, Huai Chiang, Deqiang Lu, ZhengpingXu*. Effects of Global System for Mobile Communications 1800 MHz radiofrequency electromagnetic fields on gene and protein expression in MCF-7 cells. Proteomics 2006 Sep; 6 (17): 4732-4738. PMID: 16888767 (# Co-first authors)
17. 魏晓霞, 许正平, 陈光弟. 移动电话射频电磁场暴露促动物肿瘤发展作用的研究进展. 中华劳动卫生职业病. 2016, 34(2): 155-158.
18. 赵新元, 方文攀,林晨,陈光弟. 极低频电磁场暴露与不良妊娠结局风险关联研究进展. 高电压技术. 2015, 41(4): 1383-1389.
19. 苏丽玲, 金明娟, 许正平, 陈光弟. 职业性极低频电磁场暴露与神经退行性疾病发病关联的研究进展. 中华流行病学杂志. 2014, 35(8): 965-969.
20. 许正平, 陈光弟. 细胞水平电磁场生物学效应研究的发展方向. 中华劳动卫生职业病杂志. 2012, 30 (3): 161-162.

联系方式

电子信箱:chenguangdi@zju.edu.cn