Profile

Dr. Hu obtained his medical education at Zhejiang University and a Ph.D. in clinical pharmacology at the Karolinska Institute, Sweden. He was a postdoctoral fellow in the Center for Molecular and Vascular Biology at Katholic University of Leuven. He is now the principal investigator of the Laboratory of Thrombosis and Haemostasis and the deputy dean of department of pathology and pathophysiology at Zhejiang University.


Research work

Circulating platelets form hemostatic plugs to prevent blood loss upon vascular injury, whilst excessive activation of platelets may cause pathological thrombosis and lead to life-threatening diseases such as myocardial infarction and stroke. Platelet activation is also important in wound healing, inflammation, angiogenesis, and tumor metastasis. A pivotal step during platelet activation is the release of multiple bioactive compounds from platelet dense and alpha granules. Our current research focus is to understand the molecular mechanism governing platelet activation, especially the signal networks controlling platelet granule release. This research will enhance our understanding of the roles of platelets in multiple physiological and pathophysiological processes. It may also help to identify potential prevention or therapeutic targets for diseases in which platelets are critically involved. The exploration of the novel molecules involved in platelet activation has resulted multiple publications in journals such as Blood 2016, Arteriosclerosis Thrombosis and Vascular Biology 2017, Journal of Thrombosis and Haemostasis 2010, 2013, Thrombosis and Haemostasis 2014. The lab is currently supported by fundings from National Natural Science Foundation of China and Natural Science Foundation of Zhejiang province. Contact: huhu@zju.edu.cn

Contact

Phone:0571-88208517
E-mail:huhu@zju.edu.cn