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Ai-Min Bao

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Dr. Ai-Min Bao, from Medical Endocrinological background,  graduated and obtained her PhD in Neurobiology from the University of Science and Technology of China in June 2003, and continued her research as a post-doc in the Netherlands Institute of Neuroscience (NIN), an Institute of the Royal Academy of Arts and Sciences from 2004 to 2007. From Oct 2007 to now, she is a Professor in the Department of Neurobiology at the Zhejiang University School of Medicine (ZUSM) and the Neuroscience Institute of Zhejiang University. She is currently vice Director of Department of Neurobiology, ZUSM; vice Director of China Brain Bank, ZUSM (2015 - ); Vice General Secretary of the Stress Neurobiology, Chinese Society of Neuroscience (Jan 2017- ); vice Chair of Human Brain Bank Research Branch, Chinese Society for Anatomic Science (2015 - ). She is Council member of Zhejiang Provincial Neuroscience Academy of China (2013 - ). In addition, she is the Visiting Professor of the NIN, an Institute of the Royal Academy of Arts and Sciences, vice Director of the Consciousness Science and Oriental Tradition Research Center, Zhejiang University School of Humanity (2012 - ). Ai-Min Bao also serves on the editorial boards of Gerontology and functioned as one of the Program committee members of The Biennial International Symposium on Neurobiology and Neuroendocrinology of Aging, Bregenz, Austria from 2012.

 

Aimin Bao’s lab has long been engaged in the study of neurobiological pathogenesis of depression and neurodegenerative diseases such as Alzheimer's disease (AD). Using postmortem human brain material to obtain molecular and neuropathological evidence, then in animal models and cell lines to elucidate the molecular interaction mechanism. They have published more than 40 papers in SCI journals such as Brain, Mol Psychiatry, Trends Neurosci., which have obtained more than 800 citations. Aimin Bao has been invited to participate as speaker in domestic and international academic conferences. She won a Second Prize for The Natural Science of the Ministry of Education of the People's Republic of China (2014). In 2015 Prof. Bao and her colleagues formally established the China Brain Bank, Zhejiang University School of Medicine, which is the first Chinese human brain bank that fully meets strict international standards. At present, 132 human brains have been collected by autopsy. The Brain Bank will assist the development of China's brain research and provide the most crucial and valuable research materials.

 

Prof. Bao Aimin also makes an effort to transfer modern neuroscience knowledge to the society or the general public. She actively organizes and participates in cross-disciplines exchange forums such as medical colleges, Humanities colleges, and Art colleges, and also gave talks in TV such as Phoenix Satellite TV, Zhejiang TV Station, and SELF Forum, explaining the effect of brain research on society. In recent years, she has received the Zhejiang University Excellent Teaching Award, Zhu Kezhen Academy's ‘Outstanding Contribution to the Development of Undergraduate Education" honorary certificate, award of Zhejiang Province Outstanding Teachers, and she has won the first prize of the 12th Zhejiang University Lin Baixin High-Tech Award.

Research work

Neuropsychiatric disorders are age- and sex-related and ranking in the top of the total disease-burden. It is therefore urgent to explore the pathogenesis of these disorders in order to develop adequate prevention and treatment strategies. Genetic and environmental (epigenetic) factors both play a role in the pathogenesis of these brain disorders, which are extremely difficult to model in experimental animals. While some symptoms may be reproduced, no animal model recapitulates a full-blown neuropsychiatric brain disorder at present. For some human disorders (suicide, gender identity disorder) there are even no animal models available. We therefore believe that, to decode the genetic, epigenetic, molecular and etiopathogenic underpinning of normal and abnormal brain functions, there is no alternative than directly study the human brain. In addition, the available animal models need to be validated on human brain material. Therefore, our lab’s focus is on postmortem human brain study.