Profile
PERSONAL DATA

 
 
 
 
 
 
 
 
 
 
 
 
Present Position:
Associate Professor of Department of Immunology,
Medical School of Zhejiang University
Address:
388 Yu Hang Tang Road, Hangzhou ,
Zhejiang Province,China,310058
Tel
86-571-88208286
Fax:
86-571-88208285
E-mail:
chenjianzhong@zju.edu.cn

EXPERIENCE

2003-present
Associate Professor
Department of Immunology, Medical School of Zhejiang University
Teaching undergraduate students in course of immunology and doing research in immunology
1998-2002
Lecturer
Department of Immunology, Medical School of Zhejiang University
Teaching undergraduate students in course of immunology and doing research in immunology
1994-1997
Teaching Assistant
Department of Immunology, Zhejiang Medical University
Teaching undergraduate students in course of immunology and doing research in immunology
1986-1991
Laboratorian
Ninbo Women & Children Hospital, Zhejiang Province,China
Doing immunological, bacterial and clinical laboratory work

EDUCATION

2001-2003
Post Doctorate.Majored in IFN signaling
Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo
1996-2000
Ph.D student ,Majored in Infectious Disease
Medical School of Zhejiang University
1991-1994
Master Degree student , Majored in Immunology
Hunan Medical University

RESEARCH EXPERIENCE
2003.10-present
TLR play an important role in innate immunity and its role in chronic hepatitis has received increased attention. To explore the relationship between the TLR and chronic HBV infection, we investigated the expression of TLR and related genes in hepatocytes and the interface of virus proteins of HBV such HBcAg,HBsAg in TLR signaling. The project “Regulation of IFN-beta expression of hepatocytes induced by virus PAMPs and its mechanism (Y207534)Granted by natural science foundation of Zhejiang province.  
2001.10-2003.09
As a Post.D, I do research work in IFN signaling and its function in tumor. We found that IFN play an important role in anti-tumor by increasing the expression of p53 protein to inhibit the growth of tumour cells.
1998.07-2001.09
As a second cooperator, our project “Immunostimutory sequence enhance the vaccination of Der.f ”was granted by national nature science foundation, P.R.China. In this project, cell cuture, gene transfection, in situ hybridization and DNA sequencing are being used.
1996.09-2000.06
Ph.D student in Institute of Infectious Disease, Zhejiang University, engaged in DNA vaccines. My doctor dissertation is “Immune response induced in mice by co-delivery of interleukin-18 recombinant and hepatitis B virus DNA vaccines”. In the thesis, we found that the plasmid encoding IL-18 together with HBV S gene DNA vaccines may slightly enhance humoural response and significantly enhance the specific CTL response induced in mice. In the research,molecular cloning, protein expression, detection of CTL response and quantitation of cytokines by ELISA were used.
 
 
 
1991.09-1994.07
Master degree student in institute of immunology, Hunan Medical University. My master dissertation is “Effect of hydrogen peroxide on gene expression of IL-2 in mouse splenocytes”. It is part of project “The relationship of oxygen free radical and IL-2” granted by national nature science foundation, P.R.China. In this thesis, the effect of hydrogen peroxide on IL-2 production and IL-2 mRNA expression in mouse splenocytes was detected by cellular immunological and molecular biological methods such as dot hybridization.
 
PUBLICATION
(1)    Chen J,Zhu H CHEN Z, Liu K. Construction of eukaryotic expression plasmid of murine TLR3 and identification of its biological activity. Chin J Microbiol Immunol. 2004;24(6):447-450
(2)    Chen J, Zhu HH, Liu KZ, Chen Z. Enhancing cellular immune response to HBV M DNA vaccine in mice by co-delivery of interleukin-18 recombinant. J Zhejiang Univ Sci. 2004; 5 (4):467-471
(3)    Zhu H, Chen J, Chen Z, Liu K, Cao H, Wu W. The effect of thymosin alpha 1 on expression profiles of signal transductors involving anti-infection in human lymphocytes. Chin J Infect Dis. 2003;21(3):221 -224
(4)    Chen J, Zhu H, Liu K, Chen Z. Construction of HBV S gene recombinan t and its immun ity induced in m ice. Journal of Zhejiang University (Medical Science). 2002;31(6):440-443
(5)    Chen J, Zhu H, LIU K , Chen Z .Immune response induced in mice by codelivery of interleukin-18 recombinant and HBV S gene DNA vaccine. Chin J Infect Dis 2002;20(3):156-159
(6)    Chen J, Guo S. Effect of hydrogen peroxide on expression of interleukin-2 s in mice spleenocytes.Bulletin of Hunan Medical University,1999; 24(1):5-8
(7)    Chen J, Zhu H, LIU K , Chen Z Immune response induced by different hepatitis B virus DNA vaccines in mice. Journal of Zhejiang University (Medical Science),1999;28(5):193-195
 
 
CURRENT RESEARCH FUNDING/SUPPORT
1 Regulation of IFN-beta expression of hepatocytes induced by virus PAMPs and its mechanism (Y207534),Granted by natural science foundation of Zhejiang province.
2Negative regulation of immune recognition and its intervention in transplantation reject response. (2009CB522402),Granted by Major State Basic Research Development Program.
 
SCIENTIFIC MEMBERSHIP
1997-present Board member. Chinese Association of Immunology.
Research work

infection and Immunology:innate immunity and anti-infection,immunopathogenesis of viral hepatitis and its immunoprophylaxis and immunotherapy

Contact

Phone:0571-88208286
E-mail:chenjianzhong@zju.edu.cn