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Id VisitTime IPAddress Area
23519156 2018-05-22 54.162.163.181 美国
23504877 2018-05-21 182.186.168.70 巴基斯坦
23443210 2018-05-20 218.247.40.87 广东省东莞市
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23329729 2018-05-17 222.205.84.195 浙江省杭州市
23324579 2018-05-17 10.71.223.216 局域网
23324414 2018-05-17 10.189.238.242 局域网
23318110 2018-05-17 115.204.111.205 浙江省
23316951 2018-05-17 183.158.242.45 浙江省
23314543 2018-05-17 54.36.148.205 美国
23276534 2018-05-16 10.71.120.76 局域网
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23215681 2018-05-13 175.110.96.114 巴基斯坦
23215608 2018-05-13 39.51.168.134 亚太地区
23189448 2018-05-12 125.209.235.167 韩国
GuoLab
Molecular Physiology and Biophysics Lab

Profile

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Jiangao Guo lab is working on structural biology of membrane proteins including ion channels and transporters, using single particle cryo-EM, x-ray crystallography, electrophysiology and other biophysical and biochemical techniques. The long-term goal is to elucidate ion transport mechanisms and provide structural information for related disease treatment in clinical practice.


Selected publications

1. She J*, Guo J*, Chen Q*, Zeng W, Jiang Y, Bai X. Structural insights into the voltage and phospholipid activation of mammalian TPC1 channel. Nature 556, 130-134 (2018) (*co-first authors)

2. Guo J*, She J*, Zeng W, Chen Q, Bai X, Jiang Y. Structures of the Calcium-activated Non-Selective Cation Channel TRPM4. Nature 552: 205–209 (2017) (*co-first authors)

3. Chen Q*, She J*, Zeng W, Guo J, Xu H, Bai X, Jiang Y. Structure of mammalian endolysosomal TRPML1 channel in nanodiscs. Nature 550:415-418 (2017) (* co-first authors)

4. Lee C, Guo J, Zeng W, Kim S, She J, Cang C, Ren D, and Jiang Y. The lysosomal potassium channel TMEM175 adopts a novel tetrameric architectureNature 547: 472-475 (2017)

5. Guo J, Zeng W, Jiang Y. Tuning the ion selectivity of two-pore channels. Proc Natl Acad Sci USA 114(5):1009-1014 (2017)

6. Guo J, Zeng W, Chen Q, Lee C, Chen L, Yang Y, Cang C, Ren D, Jiang Y. Structure of the voltage-gated two-pore channel from Arabidopsis thalianaNature 531:196–201 (2016)

7. Wei X, Guo J, Li M and Liu Z. Structural mechanism underlying the specific recognition between the Arabidopsis state-transition phosphatase TAP38/PPH1 and phosphorylated light-harvesting complex protein Lhcb1. The Plant Cell 27(4):1113-27 (2015)

8. Guo J, Wei X, Li M, Pan X, Chang W and Liu Z. Structure of the catalytic domain of a State transition kinase homolog from Micromonas algae. Protein Cell 4(8):607-19 (2013)

Research work

1. ion channel structural biology 2. ion transporters structural biology 3. structure-based drug development targeting to ion channels and transporters