Last Activity

Id VisitTime IPAddress Area
23519166 2018-05-22 美国
23505112 2018-05-21 巴基斯坦
23391039 2018-05-19 北京市
23318098 2018-05-17 浙江省
23316934 2018-05-17 浙江省杭州市
23314156 2018-05-17 美国
23259213 2018-05-15 中国
23247157 2018-05-15 局域网
23247109 2018-05-15 局域网
23247036 2018-05-15 局域网
23244777 2018-05-15 美国
23221681 2018-05-14 云南省
23201806 2018-05-13 北京市
23125328 2018-05-11 美国
23102244 2018-05-10 亚太地区
Honghe Zhang




03/2012   Department of Pathology, School of Medicine, Zhejiang University  Ph.D. in Pathology

12/2006   Department of Laboratory Medicine, Wenzhou Medical College  M.S. in Laboratory Medicine

07/2000   Department of Laboratory Medicine, Xiangya School of Medicine, Central South University  B.S. in Laboratory Medicine


Training and Work Experience:

03/2012-present  Department of Pathology, School of Medicine, Zhejiang University

07/2015-08/2015  Medical College of Wisconsin, Department of Physiology. Vistor Scholar

12/2013-12/2014   Medical College of Wisconsin, Department of Physiology. Postdoc

01/2013-04/2013   Ludwig Maximilians University of Munich, Institute of Pathology. Visiting Scholar

09/2003-06/2008  Department of Laboratory Medicine, The First People’s Hospital of Hangzhou. (09/2003-12/2006, as in-service training postgraduate in Wenzhou Medical College)

08/2000-08/2003 Gene Diagnosis Laboratory, The First People’s Hospital of Hangzhou.



 1. Huang D, Sun W, Zhou Y, Li P, Chen F, Chen H, Xia D, Xu E, Lai M, Wu Y, Zhang H*. Mutations of key driver genes in colorectal cancer progression and metastasis. Cancer Metastasis Rev. 2018 Mar;37(1):173-187.  

2. Wan L, Yu W, Shen E, Sun W, Liu Y, Kong J, Han F, Zhang L, Yu T, Zhou Y, Xie S, Xu E, Zhang H*, Lai M*. SRSF6-Regulated Alternative Splicing that Promotes Tumor Progression Offers a Therapy Target for Colorectal Cancer. GUT, 2017, in press.  

3. Zhang H#, Lu Y, Chen E, Li X, Lv B, Vikis HG,Liu P. XRN2 promotes EMT and metastasis through regulating maturation of miR-10a. Oncogene. 2017, 36(27):3925-3933.  

4. Lu W#, Zhang H# (Co-First), Niu Y, Wu Y, Sun W, Li H, Kong J, Ding K, Shen HM, Wu H, Xia D*, Wu Y*. Long non-coding RNA linc00673 regulated non-small cell lung cancer proliferation, migration, invasion and epithelial mesenchymal transition by sponging miR-150-5p. Mol Can, 2017;16(1):118 .

5. Wang X, Zhang L, Li H, Sun W, Zhang H*, Lai M*. THBS2 is a Potential Prognostic Biomarker in Colorectal Cancer. Sci Rep. 2016, 6:33366.

6. Kong J, Sun W, Li C, Wan L, Wang S, Wu Y, Xu E, Zhang H*, Lai M*. Long non-coding RNA LINC01133 inhibits epithelial-mesenchymal transition and metastasis in colorectal cancer by interacting with SRSF6. Cancer Lett. 2016,380(2):476-84. IF 6.375

7. Wan L, Kong J, Tang J, Wu Y, Xu E, Lai M*, Zhang H*. HOTAIRM1 as a potential biomarker for diagnosis of colorectal cancer functions the role in the tumour suppressor. J Cell Mol Med. 2016, 20(11):2036-2044.

8. Li C, Wang X, Casal I, Wang J, Li P, Zhang W, Xu E, Lai M*, Zhang H*. Growth differentiation factor 15 is a promising diagnostic and prognostic biomarker in colorectal cancer. J Cell Mol Med. 2016, 20(8): 1420-6.

9. Tang J, Li Y, Wang J, Wen Z, Lai M, Zhang H*. Molecular mechanisms of microRNAs in regulating epithelial-mesenchymal transitions in human cancers. Cancer Lett. 2016, 371(2):301-13.

10. Li C, Wang J, Kong J, Tang J, Wu Y, Xu E, Zhang H*, Lai M*. GDF15 promotes EMT and metastasis in colorectal cancer. Oncotarget. 2016 Jan 5;7(1):860-72.
11. Wang J, Li W, Wang Y, Li C, Ding M, Zhang H*, Lai M*. The H6D genetic variation of GDF15 is associated with genesis, progress and prognosis in colorectal cancer. Pathol Res Pract, 2015, 211(11):845-50.

12. Zhang H, Tang J, Li C, Kong J, Wang J, Wu Y, Xu E, Lai M. MiR-22 regulates 5-FU sensitivity by inhibiting autophagy and promoting apoptosis in colorectal cancer cells. Cancer Lett. 2015, 356:781-90.

13. Li P, Wu H, Zhang H, Shi Y, Xu J, Ye Y, Xia D, Yang J, Cai J, Wu Y. Aspirin use after diagnosis but not prediagnosis improves established colorectal cancer survival: a meta-analysis. Gut. 2015, 64(9):1419-25.

14. Wang J, Tang J, Lai M*, Zhang H*. 5-Hydroxymethylcytosine and disease. Mutat Res Rev Mutat Res. 2014, 762C:167-175.

15. Zhang H, Li P, Ju H, Pesta M, Kulda V, Jin W, Cai M, Liu C, Wu H, Xu J, Ye Y, Zhang G, Xu E, Cai J, Lai M, Xia D, Yang J, Wu Y. Diagnostic and Prognostic Value of microRNA-21 in Colorectal Cancer: An Original Study and Individual Participant Data Meta-analysis. Cancer Epidemiol Biomarkers Prev. 2014, 23(12):2783-92.

16. Li P*, Zhang H*(Co-first author), Chen J, Shi Y, Cai J, Yang J, Wu Y. Association between dietary antioxidant vitamins intake/blood level and risk of gastric cancer. Int J Cancer. 2014, 135(6):1444-53.

17. Zhang H, Li Y, Huang Q, Ren X, Hu H, Sheng H, Lai M. MiR-148a promotes apoptosis through targeting Bcl-2 in colorectal cancer. Cell Death Differ .2011,18(11): 1702-1710.

18.Zhang H, Li Y, Lai M. The microRNA network and tumor metastasis. Oncogene. 2010, 29(7):937-48. 



1. The roles of LINC00152 in colorectal cancer metastasis. The National Natural Science Foundation of China. 81672730. 2017.1-2020.12

2. The roles of S100A2 in colorectal cancer. the Fundamental Research Funds for the Central Universities. 2017.01-2018.12

3. The roles of HOTAIRM1 in colorectal cancer. The National Natural Science Foundation of China. 81201557. 2013.01-2015.12

4. The roles of TTANR in colorectal cancer. The National Natural Science Foundation of Zhejiang. LY15H160032. 2015.01-2017.12




Research work

Molecular pathology