Li Yong-Quan, Ph.DProfessor

Qiushi-Distinguished Prof. of Zhejiang University

Prof.of Microbial Molecurlar Biology and Microbial Pharmaceutics

Director of Institute of Pharmaceutical Biotechnology, Zhejiang University

Director of Zhejiang Provincial Key Lab for Microbial Biochemistry and  Metabolic Engineering

Room 401#, Biological experimental centerZhejiang University, 866# Yuhangtang Road, Hangzhou310058, China

 Brief introduction

Dr. Li Yong-Quan is a professor at Institute of Pharmaceutical Biotechnology, Zhejiang University,China. His research is interested in Microbiol Synthetic Biology, Microbial Pharmaceutics and Secondary Metabolic Engineering. He presided over a number of important projects in recent years, such as project of 863 Program, Key project of NSFC, Key Project for National New Drug Development, and so on. He has published more than 90 research articles,such as Molecular Microbiology, Journal of Biological Chemistry, Applied and Environmental Microbiology, Journal of Bacteriology etc. He completed the tacrolimus, natamycin, daptomycin and other microbial drug development, and support cooperation enterprise for a number of new drug certificate.


2016.03- Present  Director of Institute of Pharmaceutical Biotechnology 

2012-01- Present  Qiushi-Distinguished Prof. of Zhejiang University

009.12- Present Director of Zhejiang Province Key Lab of Microbial Biochemistry and Metabolic Engineering,

2006.03-2015.12  Director of Institute of Biochemistry, Zhejiang University

2010.09-2010.11  Visiting Scholar, Cornal University, USA

2007.01-2007.03   Visiting Scholar, University of Wisconsin-Madison, USA

2001.05.-2002.07  Visiting Scholar, University of Minnesota, USA

1999.01-2003.06    Ph.D. Bioengineering, Zhejiang University, China

1998.09-2001.12   Associate Professor, College of Life Science, Zhejiang University, China.

1996.01-1998.08   Associate Professor, College of Life Science, Hangzhou University, China.

1992.04-1995.12    Lecturer, College of Life  Science, Hangzhou University, China

1989.09-1992.07    M.S. Biochemical Engineering, Zhejiang University,China

Selective Publication

More than and 90 papers were published in international journals in this field

[1] Tan-Jun Wang, Yi-Ming Shan, Han Li, Wei-Wang DouXin-Hang Jiang, Xu-Ming MaoShui-Ping LiuWen-Jun Guan, Yong-Quan LiMultiple transporters are involved in natamycin efflux in Streptomyces chattanoogensis L10, Molecular Microbiology2017 103(4), 713–728

[2] Xu-Ming Mao, Shuai Luo, Ri-Cheng Zhou, Feng Wang, Pin Yu, Ning Sun, Xiao-Xia Chen, Yi Tang and Yong-Quan Li*Transcriptional regulation of the daptomycin gene cluster in Streptomyces roseosporus by an autoregulator AtrAJournal of Biological Chemistry, 2015, 29012:7992–8001.

[3]  Xu-Ming Mao, Wei-Hong Feng, Ning Sun, Zhan Zhou and Yong-Quan Li*. Dual Positive Feedback Regulation of Protein Degradation of an ECF (extra-cytoplasmic function) Sigma Factor for Cell Differentiation in Streptomyces coelicolor, Journal of  Biological Chemistry, 2013,28843):31217-31228

[4] Peng-Hui Yuan, Ri-Cheng Zhou, Xuepeng Chen, Shuai Luo, Feng Wang, Xu-Ming Mao*,Yong-Quan Li*, DepR1, aTetR-family transcriptional regulator, positively regulates daptomycin production in an industrial producer Streptomyces roseosporusSW0702, Applied and Environmental Microbiology, 201682(6):1898-1905

[5] Yue-Yue Wang, Xiao-Sheng Zhang, Hong-Dou Luo,, Ni-Ni Ren, Xin-Hang Jiang,Hui Jiang, Yong-Quan Li, Characterization of Discrete Phosphopantetheinyl Transferases in Streptomyces tsukubaensis L19 Unveils a Complicate Phosphopantetheinylation Network, Scientific Reports,  2016 Apr 7;6:24255.

[6] Hui Jiang, Yue-Yue Wang, Wei-Ming Fan, Xin-Hang Jiang,Wen-Jun Guan,* and Yong-Quan Li*. Improvement of Natamycin Production by Engineering of Phosphopanteth Transferases in Streptomyces chattanoogensis L10, Applied and Environmental Microbiology, 2013, 7911):3346-3354

[7] Yi-Ling Du,Xue-Ling Shen,Pin Yu,Lin-Quan Bai,and Yong-Quan Li*. Gamma-Butyrolactone Regulatory System of Streptomyces chattanoogensis Links Nutrient Utilization,Metabolism and Developmental Programme, Applied and Environmental Microbiology, 2011,7723):8415-8426

[8] Pin Yu, Shui-ping Liu, Qin-Ting Bu, Zhen-Xing Zhou, Zhen-Hong Zhu, Fang-Liang Huang , Yong-Quan Li*,  WblAch, a Pivotal Activator of Natamycin Biosynthesis and Morphological Differentiation in Streptomyces chattanoogensis L10, Is Positively Regulated by AdpAch, Applied and Environmental Microbiology, 2014,80(22):6879-6887; 

[9] Guo, Yuanyang; Li, Han; Zhou, zhenxing; Mao, Xu-Ming; Tang, Yi; Chen, Xin; Jiang, Xin-Hang; Liu, Yu; Jiang, Hui; Li, Yong-Quan*. Identification and Biosynthetic Characterization of Natural Aromatic Azoxy Products from Streptomyces chattanoogensis L10,Organic Letters, 2015, 17:6114−6117

[10] Shui-Ping LiuPin Yu, Peng-Hui YuanZhen-Xing Zhou,Qing-Ting Bu, Xu-Ming Mao and Yong-Quan Li*, Sigma factor WhiGch positively regulates natamycin production in Streptomyces chattanoogensis L10, Applied Microbiology and Biotechnology, 2015,99(6):2715-2726;

[11] Zhen-Xing Zhou,Qing-Qing Xu,Qing-Ting Bu,Shui-Ping Liu, Pin Yu, Yong-Quan Li*, Transcriptome-guided identification of SprA as a pleiotropic regulator in Streptomyces chattanoogensis , Applied Microbiology and Biotechnology, 201599 (3):1287-1298;

[12] Zhen-Hong Zhu, Han Li, Pin YuYuan-Yang Guo, Shuai Luo, Zhong-Bin Chen, Xu-Ming Mao, Wen-Jun Guan, Yong-Quan Li*, SlnR is a positive pathway-specific regulator for salinomycin, Appl Microbiol Biotechnol, 2016,100(23), DOI 10.1007/s00253-016-7918-5

[13] Zhenxing Zhou,Qingqing Xu,Qingting Bu,Yuanyang Guo,Shuiping Liu,Yu Liu,Yiling Du,Yongquan Li*, Genome Mining-Directed Activation of a Silent Angucycline Biosynthetic Gene Cluster inStreptomyces chattanoogensis, ChemBioChem, 2015, 16(3):496-502

[14] Xu-Ming Mao, Zhi-Hao Sun, Bi-Rong Liang, Zhi-Bin Wang, Fang-Liang Huang, Yong-Quan Li*. Positive feedback regulation of StgR expression for secondary metabolism in Streptomyces coelicolor, Journal of Bacteriology, 2013,1959):2072-2078.

[15] Yi-Ling Du, Shan-Zhen Li, Zhan Zhou, Shi-Fei Chen, Wei-Min Fan, Yong-Quan Li*.The pleitropic regulator AdpAch is required for natamycin biosynthesis and morphological differentiation in Streptomyces chattanoogensis. Microbiology-sgm, 2011, 157: 1300–1311

[16] Jiang H, Wang YY, Guo YY, Shen JJ, Zhang XS, Luo HD, Ren NN, Jiang XH, Li YQ*. An Acyltransferase Domain of FK506 Polyketide Synthase Recognizing Both an Acyl Carrier Protein and Coenzyme A As Acyl Donors To Transfer Allylmalonyl and Ethylmalonyl Units. FEBS J. 2015, 282: 2527–2539

Responsible main projects in recent years

[1] Key project of the National Natural Science FoundationNo31730002),Temporal regulatory mechanisms of the regulatory pathway for secondary metabolic process in Streptomyces,  2016.01-2020.12

[2] Key international cooperation project of the National Natural Science FoundationNo31520103901The molecular mechanism of cryptic gene cluster activation for secondary metabolites in Streptomyces, 2016.01-2020.12

[3] General  project of the National Natural Science Foundation, Molecular mechanism of acyl transferase in type I polyketide synthaseNo 31470212,2015.01-2018.12

[4] Subproject of 973 Program National Basic Research Program of China),Analysis and optimization of drug synthesis pathwayNo2012CB721005),2012.01-2016.12

[5] project of 863 ProgramResearch and application of high efficient synthesis of microbial drugsNo2012AA02A706),2012.11-2015.12

[6]  National Key Project for New Drug DevelopmentThe development of new drug daptomycin against multidrug-resistant bacteriaNo2011ZX09202-101-11, 2011.01-2013.12

[7] Subproject of National Key technology R and D programResearch and development of a new type of food preservative NatamycinNo 2011BAD23B05-2,2011.01-2015.12

[8]  general  project of the National Natural Science Foundation, Regulation mechanism of sigma factor in StreptomycesNo 31070040 , 2011.01-2013.12

[9] general  project of the National Natural Science FoundationMolecular mechanism of protein transduction mediated by Streptomyces SRP pathwayNo30870033,2009.01-2011.12






















Research work

Microbiol Synthetic Biology, Microbial Pharmaceutics and Secondary Metabolic Engineering