Current Projects:

1. Operating: Study on the changes of expression profiles of genomic imprints in the low-birth-body-weight offspring born following assisted reproduction techniques and the related molecular mechanisms, granted from The National Natural Science Fund of China (2011-2013, No. 81070541)

2.Participating: Risk assessment of embryo-fetus-originated adult diseases resulted from assisted reproduction and research on the related mechanisms , granted from The National Basic Research Progrom, the Ministry of Science & Technology, China (2012-2016, No. 2012CB944900)

Completed Projects:
1.Operating: The dynamic investigation of genomic imprints expression profiles and changes of assisted conceptions and the related mechanisms, granted from The National Natural Science Fund of China (2007-2009, No. 30671161)

2.Participating: Role of oocyte-derived growth factors in human ovarian follicle development, granted from China-Canada Joint Health Res (2008-2010, No. 30711120577)

Selected papers:
1.Yin LJ, Zhang Y, Lv PP, He WH, Wu YT, Liu AX, Ding GL, Qu F, Xu CM, Dong MY, Zhu XM and Huang HF: Insufficient maintenance DNA methylation is associated with abnormal embryonic development. BMC Medicine 2012, 10:26

2.Feng C, Tian S, Zhang Y, He J, Zhu XM, Zhang D, Sheng JZ, Huang HF, General imprinting status is stable in assisted reproduction-conceived offspring.  Fertil Steril, 2011; 96:1417–23

3.He RH, Zhu XM, How to deal with fluid in the endometrial cavity during assisted reproductive techniques.Curr Opin Obstet Gynecol. 2011; 23(3):190-4

4.He RH, Gao HJ, Li YQ, and Zhu XM, The associated factors to endometrial cavity fluid and the relevant impact on the IVF-ET outcome. Reprod Biol Endocrinol, 2010. 8:46

5.Tang L, Zhang Y, Pan H, Luo Q, Zhu X-M , Dong M-Y, Leung P, Sheng J-Z, and Huang H-F, Involvement of cyclin B1 in progesterone-mediated cell growth inhibition, G2/M cell cycle arrest, and apoptosis in human endometrial cell. Reprod Biol Endocrinol, 2009. 7(1):144

6.Lin K, Zhu X, Xu H, Liang Z, Zhang X: Reproductive outcome following resectoscope metroplasty in women having a complete uterine septum with double cervix and vagina. Int J Gynaecol Obstet. 2009;105(1):25-8

7.Zhu X M, Zhu Y M, Huang H F, et al: Autologous mature follicular fluid: its role in in vitro maturation of human cumulus-removed oocytes. Fertil Steril, 2008; 90(4):1094-102.

8.Yan-Ting Wu, Li Tang, Jie Cai, Xiu-E Lu, Jian Xu, Xiao-Ming Zhu, Qiong Luo and He-Feng Huang: High bone morphogenetic protein-15 level in follicular fluid is associated with high quality oocyte and subsequent embryonic development. Hum Reprod, 2007, 21(6):1526-31

9.Ai-Xia Liu, Yi-Min Zhu, Qiong Luo, Yan-Ting Wu, Hui-Juan Gao, Xiao-Ming Zhu, Chen-Ming Xu and He-Feng Huang: Specific peptide patterns of follicular fluids at different growth stages analyzed by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Biochim Biophys Acta, 2007, 1770(1):29-38

10.Luo Q, Ning WX, Wu YT, Zhu XM, Jin F, Sheng JZ, Huang HF, Altered expression of interleukin-18 in ectopic and eutopic endometrium of women with endometriosis. J Reprod Immunol 2006; 72:108-17

11.Luo, Q., Yang, J., Zeng, Q. L., Zhu, X. M., Qian, Y. L., Huang, H. F.: 50-Hertz electromagnetic fields induce gammaH2AX foci formation in mouse preimplantation embryos in vitro. Biol Reprod. 2006; 75:673-80

12.Jin L, Zhu X M, Huang H F, et al: A novel SNP at exon 17 of the INSR gene is associated with decreased insulin sensitivity in the Chinese women with PCOS. Mol Hum Reprod 2006, 12(3):151-155

13.Ruan H C, Zhu X M, Huang H F., et al: Ovarian stimulation with GnRHa, but not GnRHant, might restore the expression of endometrial integrin β3 and leukemia inhibitory factor and improve uterine receptivity in mice. Hum Reprod, 2006, 21(10):2521-2529

14.Leung PC, Cheng CK, and Zhu XM, Multi-factorial role of GnRH-I and GnRH-II in the human ovary. Mol Cell Endocrinol, 2003, 202:145-53

15.Lau H.L., Zhu X.M., Leung P.C., et al., Detection of mRNA expression of gonadotropin-releasing hormone and its receptor in normal and neoplastic rat prostates. Int J Oncol, 2001, 19:1193-201)

Research work

--Reproductive endocrinology & aging --Infertility & Assisted reproductive techniques --Reproductive safety & the prevention and control of birth defects


Phone:0086 571 87061501-1832