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11205898 2017-04-28 107.22.60.105 北美地区
11204664 2017-04-28 10.189.216.24 局域网
11203282 2017-04-28 115.155.67.87 陕西省西安市
11203274 2017-04-28 117.136.89.89 中国
11202948 2017-04-28 10.189.88.38 局域网
11202725 2017-04-28 112.17.243.65 中国
11202600 2017-04-28 112.17.236.23 中国
11202583 2017-04-28 112.17.247.149 中国
11202473 2017-04-28 101.226.99.195 上海市
11202456 2017-04-28 10.189.84.250 局域网
11202455 2017-04-28 180.153.214.180 上海市
11199817 2017-04-28 61.151.218.118 上海市
11199814 2017-04-28 36.23.198.5 中国
11199810 2017-04-28 112.17.238.179 中国
11198852 2017-04-28 42.156.138.54 亚太地区
0005020
Ouyang HW
28
Apr

Profile

 
Position Title
Dean, ZJU-UoE Institute
Vice Dean,School of Medicine,Zhejiang University,China
Dean, School of Basic Medicine,Zhejiang University,China
Professor of Orthopaedic Surgery and Tissue Engineering,School of Medicine,Zhejiang University,China
Qiu-shi Distinguished Professor,Zhejiang University,China
 
Contact Information
#39 Center for Stem Cell and Tissue Engineering,
School of Medicine, Zhejiang University
#866 Yu Hang Tang Road,
Hangzhou, Zhejiang, P.R.China, 310058
Tel: 86-571-88208262
Fax: 86-571-88208262
Email: hwoy@zju.edu.cn
http://person.zju.edu.cn/ouyanghongwei
http://term.zju.edu.cn/
 
Education & Working Experience
Education Background
Date
School
Degree and Major
1986.9-1989.6
Hengyang county no.1 middle school,China
 
1989.9-1994.6
Hunan Medical University,China
M.D/ Clinical Medicine
2000.1-2003.11
National University of Singapore,Singapore
Ph.D/ Tissue Engineering
Working Experience
Date
Company / Work unit
Position
1994-1999
Dept of Orthopedic Surgery, Xiangya Hospital, Hunan Medical University, China
Orthopedic Specialist
2002-2004
Division of Bioengineering, National University of Singapore (NUS), Singapore
Postdoc
2004-2005
Dept of orthopedic surgery, National University Hospital NUS,         Singapore
Clinical Scientist
2005-Present
School of Medicine, Zhejiang University, China
Professor/deputy director
2013-present
School of Basic Medical Sciences, Zhejiang University, China
Dean
2013-present
School of Medical Sciences, Zhejiang University, China
Vice dean
 
Positions,Employment and Honors
l   2015-Present   Dean of ZJU-UoE Institute
l   2013-Present  Vice Dean,School of Medicine,Zhejiang University,China.
l   2011-Present  Dean, School of Basic Medical Sciences, Zhejiang University, China.
l   2010-Present  Professor, School of Biological Medicine, Chinese University Hong Kong.
l   2009-2011    Vice Dean, School of Basic Medical Sciences, Zhejiang University, China.
l   2005-Present  Professor/doctorial tutor, School of Medicine, Zhejiang University, China.
l   2004-2005    Clinical Scientist, Dept of orthopedic surgery, National University Hospital,NUS, Singapore.
l   2003-2004    Postdoc in Division of Bioengineering, National University of Singapore (NUS), Singapore.
l   1999-2003   PhD Scholar, Dept of Orthopedic Surgery, National University of Singapore, Singapore (NUS).
l   1994-1999  Orthopedic Specialist, Dept of Orthopedic Surgery, Xiangya Hospital, Hunan Medical University, China.
 
Professional Memberships
l   Committee member,Asia-Pacific Chapter.International tissue engineering society
l   Alternate Director,China Tissue Engineering and Regenerative Medicine Society
l   Editor Board member, Biomaterials
l   Fellow, International Combined Orthopaedic Research Societies
l   Group leader,Chinese Association of Orthopaedic surgeons Working group on regenerative medicine
l   Vice chairman,Chinese Association of Orthopaedic surgeons Based committee
l   Director,Zhejiang Provincial Key Laboratory of tissue engineering and regenerative medicine
l   Chairman, Zhejiang Provincial Biomedical Society
l   Final expert, EP-7 fund
l   External evaluation experts, BBSRC Research Grant Council in UK
l   External evaluation experts,Research Grants Council(RGC) of Hong Kong
l   Vice-editor,<systematic anatomy>People's Medical Publishing House
 
Honors and Awards
l   2011,National Outstanding Investigator,China National Scientific Foundation Society(NSFC).
l   2011,National Talent-1000,China Central Govement.
l   2012,Science and Technology Progress Award,China national Ministry of Education.
l   2014,Natural science Award,China national Ministry of Education.
l   2014,Top ten Orthopaedic young doctor,Chinese Association of Orthopaedic surgeons
 
Main Research Support
1.        (PI) National natural science foundation of China, Key Grants, Subtype identification and regeneration of degenerative osteoarthritis, 2017-2021
2.        (PI) Ministry of Science and Technology, Key Grants, Key technology and supporting platform of material-gene engineering:High throughput manufacturing, evaluation and clinical trials of Cartilage inducing materials, 2016-2020
3.        (PI) Science and technology department of zhejiang province, Creative Team, the key scientific and technological innovation team of musculoskeletal tissue engineering and regenerative medicine, 2014-2016
4.        (PI) National natural science foundation of China, Key Grants, Transcriptional regulation on differentiation of SCX+NES+ tendon stem cell subset, 2014-2018
5.        (PI) National High Technology Research and Development Program of China (863 Program), Grants, Developing key practical and prospective tissue regeneration technologies and products, 2012-2015
6.        (PI) National natural science foundation of China, National Outstanding Investigator, Sports medicine, 2012-2015
7.        (PI) National Key Scientific Program, Grants 2012-2015
 
 
Selected Publications
Article
Stem cells and Sports Medicine
1.        Yin, Z; Hu, JJ; Yang, L; Zheng, ZF; An, CR; Wu, BB; Zhang, C; Shen, WL; Liu, HH; Chen, JL; Heng, BC; Guo, GJ; Chen, X; Ouyang, HW, Single-cell analysis reveals a nestin(+) tendon stem/progenitor cell population with strong tenogenic potentiality, SCIENCE ADVANCES, 2016;2(11), doi:e1600874,10.1126/sciadv.1600874 Science series
2.        Jun Dai, Dongsheng Yu, Yafei Wang, Yishan Chen, Heng Sun, Xiaolei Zhang, Shouan Zhu, Zongyou Pan, Boon Chin Heng, Shufang Zhang, Hongwei Ouyang, Kdm6b regulates cartilage development and homeostasis through anabolic metabolism. ANNALS OF THE RHEUMATIC DISEASES, 2016; 0:1-9, doi:10.1136/annrheumdis-2016-210407 IF:12.384
3.        Zhu, SA; Lu, P; Liu, HH; Chen, PF; Wu, Y; Wang, YY; Sun, H; Zhang, XL; Xia, QQ; Heng, BC; Zhou, YT; Ouyang, HW, Inhibition of Rac1 activity by controlled release of NSC23766 from chitosan microspheres effectively ameliorates osteoarthritis development in vivo, ANNALS OF THE RHEUMATIC DISEASES, 2015;74(1):285-293, doi:10.1136/annrheumdis-2013-203901 Highlighted by Nature Review Rheum. Best pepper ICRS 2013 IF:12.384
4.        Jiang, YZ; Cai, YZ; Zhang, W; Yin, Z; Hu, CC; Tong, T; Lu, P; Zhang, SF; Neculai, D; Tuan, RS; Ouyang, HW, Human Cartilage-Derived Progenitor Cells From Committed Chondrocytes for Efficient Cartilage Repair and Regeneration, STEM CELLS TRANSLATIONAL MEDICINE, 2016;5(6):733-744, doi:10.5966/sctm.2015-0192 Highlight by STEM CELLS. Reported by NSFC to Central Committee and department in Aug. 2016
5.        Tang, QM; Chen, JL; Shen, WL; Yin, Z; Liu, HH; Fang, Z; Heng, BC; Ouyang, HW; Chen, X, Fetal and adult fibroblasts display intrinsic differences in tendon tissue engineering and regeneration, SCIENTIFIC REPORTS, 2014;4:5515, doi:10.1038/srep05515 Highlighted by Nature website NGP Asia-Pacific in “Research Highlight” Column
6.        Hu, JJ; Yin, Z; Shen, WL; Xie, YB; Zhu, T; Lu, P; Cai, YZ; Kong, MJ; Heng, BC; Zhou, YT; Chen, WS; Chen, X; Ouyang, HW, Pharmacological Regulation of In Situ Tissue Stem Cells Differentiation for Soft Tissue Calcification Treatment, STEM CELLS, 2016
7.        Liu, HH; Zhang, C; Zhu, SA; Lu, P; Zhu, T; Gong, XN; Zhang, ZW; Hu, JJ; Yin, Z; Heng, BC; Chen, X; Ouyang, HW, Mohawk Promotes the Tenogenesis of Mesenchymal Stem Cells Through Activation of the TGF beta Signaling Pathway, STEM CELLS, 2015
8.        Yin, Z; Guo, J; Wu, TY; Chen, X; Xu, LL; Lin, SE; Sun, YX; Chan, KM; Ouyang, HW; Li, G,Stepwise Differentiation of Mesenchymal Stem Cells Augments Tendon-Like Tissue Formation and Defect Repair In Vivo, STEM CELLS TRANSLATIONAL MEDICINE, 2016
9.        Zhu, SA; Chen, PF; Wu, Y; Xiong, S; Sun, H; Xia, QQ; Shi, LB; Liu, HH; Ouyang, HW, Programmed Application of Transforming Growth Factor beta 3 and Rac1 Inhibitor NSC23766 Committed Hyaline Cartilage Differentiation of Adipose-Derived Stem Cells for Osteochondral Defect Repair, STEM CELLS TRANSLATIONAL MEDICINE, 2014
10.      Shen, WL; Chen, JL; Zhu, T; Chen, LK; Zhang, W; Fang, Z; Heng, BC; Yin, Z; Chen, X; Ji, JF; Chen, WS; Ouyang, HW, Intra-Articular Injection of Human Meniscus Stem/Progenitor Cells Promotes Meniscus Regeneration and Ameliorates Osteoarthritis Through Stromal Cell-Derived Factor-1/CXCR4-Mediated Homing, STEM CELLS TRANSLATIONAL MEDICINE, 2014
11.      Xia, QQ; Zhu, SA; Wu, Y; Wang, JQ; Cai, YZ; Chen, PF; Li, J; Heng, BC; Ouyang, HW; Lu, P, Intra-Articular Transplantation of Atsttrin-Transduced Mesenchymal Stem Cells Ameliorate Osteoarthritis Development, STEM CELLS TRANSLATIONAL MEDICINE, 2015
12.      Zhu, SA; Dai, J; Liu, HH; Cong, XX; Chen, YS; Wu, Y; Hu, H; Heng, BC; Ouyang, HW; Zhou, YT, Down-Regulation of Rac GTPase-Activating Protein OCRL1 Causes Aberrant Activation of Rac1 in Osteoarthritis Development, ARTHRITIS & RHEUMATOLOGY, 2015
Biomaterials and musculoskeletal tissue engineering
1.     Wu, Y; Zhu, SA; Wu, CT; Lu, P; Hu, CC; Xiong, S; Chang, J; Heng, BC; Xiao, Y; Ouyang, HW, A Bi-Lineage Conducive Scaffold for Osteochondral Defect Regeneration, ADVANCED FUNCTIONAL MATERIALS, 2014;24(28): 4473-4483, doi:10.1016/j.biomaterials.2015.02.071, IF:11.382
2.     Yin, Z; Chen, X; Song, HX; Hu, JJ; Tang, QM; Zhu, T; Shen, WL; Chen, JL; Liu, HH; Heng, BC; Ouyang, HW, Electrospun scaffolds for multiple tissues regeneration in vivo through topography dependent induction of lineage specific differentiation, BIOMATERIALS, 2015; 44: 173-185, doi:10.1016/j.biomaterials.2015.04.060, Top ESI 1%
3.     Liu, HH; Peng, HJ; Wu, Y; Zhang, C; Cai, YZ; Xu, GW; Li, Q; Chen, X; Ji, JF; Zhang, YZ; OuYang, HW, The promotion of bone regeneration by nanofibrous hydroxyapatite/chitosan scaffolds by effects on integrin-BMP/Smad signaling pathway in BMSCs, BIOMATERIALS, 2013; 34(18):4404-4417, doi:10.1016/j.biomaterials.2015.02.051, Top ESI 1%
4.     Wang, JJ; Wang, JQ; Lu, P; Cai, YZ; Wang, YF; Hong, L; Ren, H; Heng, BC; Liu, H; Zhou, J; Ouyang, HW, Local delivery of FTY720 in PCL membrane improves SCI functional recovery by reducing reactive astrogliosis, BIOMATERIALS, 2015
5.     Chen, X; Gu, S; Chen, BF; Shen, WL; Yin, Z; Xu, GW; Hu, JJ; Zhu, T; Li, G; Wan, C; Ouyang, HW; Lee, TL; Chan, WY, Nanoparticle delivery of stable miR-199a-5p agomir improves the osteogenesis of human mesenchymal stem cells via the HIF1a pathway, BIOMATERIALS, 2015
6.     Zhang, C; Yuan, HH; Liu, HH; Chen, X; Lu, P; Zhu, T; Yang, L; Yin, Z; Heng, BC; Zhang, YZ; Ouyang, HW, Well-aligned chitosan-based ultrafine fibers committed teno-lineage differentiation of human induced pluripotent stem cells for Achilles tendon regeneration, BIOMATERIALS, 2015
7.     Chen, PF; Tao, JD; Zhu, SA; Cai, YZ; Mao, QJ; Yu, DS; Dai, J; Ouyang, HW, Radially oriented collagen scaffold with SDF-1 promotes osteochondral repair by facilitating cell homing, BIOMATERIALS, 2015
8.     Shen, WL; Chen, X; Hu, YJ; Yin, Z; Zhu, T; Hu, JJ; Chen, JL; Zheng, ZF; Zhang, W; Ran, JS; Heng, BC; Ji, JF; Chen, WS; Ouyang, HW, Long-term effects of knitted silk-collagen sponge scaffold on anterior cruciate ligament reconstruction and osteoarthritis prevention, BIOMATERIALS, 2014
9.     Ren, H; Han, M; Zhou, J; Zheng, ZF; Lu, P; Wang, JJ; Wang, JQ; Mao, QJ; Gao, JQ; Ouyang, HW, Repair of spinal cord injury by inhibition of astrocyte growth and inflammatory factor synthesis through local delivery of flavopiridol in PLGA nanoparticles, BIOMATERIALS, 2014
10.   Chen, PF; Zhu, SA; Wang, YY; Mu, Q; Wu, Y; Xia, QQ; Zhang, XL; Sun, H; Tao, JD; Hu, H; Lu, P; Ouyang, HW, The amelioration of cartilage degeneration by ADAMTS-5 inhibitor delivered in a hyaluronic acid hydrogel, BIOMATERIALS, 2014
11.   Shi, LB; Cai, HX; Chen, LK; Wu, Y; Zhu, SA; Gong, XN; Xia, YX; Ouyang, HW; Zou, XH, Tissue engineered bulking agent with adipose-derived stem cells and silk fibroin microspheres for the treatment of intrinsic urethral sphincter deficiency, BIOMATERIALS, 2014
12.   Zhang, W; Chen, JL; Tao, JD; Hu, CC; Chen, LK; Zhao, HS; Xu, GW; Heng, BC; Ouyang, HW, The promotion of osteochondral repair by combined intra-articular injection of parathyroid hormone-related protein and implantation of a bi-layer collagen-silk scaffold, BIOMATERIALS, 2013
13.   Zhang, W; Chen, JL; Tao, JD; Jiang, YZ; Hu, CC; Huang, L; Ji, JF; Ouyang, HW, The use of type 1 collagen scaffold containing stromal cell-derived factor-1 to create a matrix environment conducive to partial-thickness cartilage defects repair, BIOMATERIALS, 2013
14.   Wang, W; Li, B; Yang, JZ; Xin, L; Li, YL; Yin, HP; Qi, YY; Jiang, YZ; Ouyang, HW; Gao, CY, The restoration of full-thickness cartilage defects with BMSCs and TGF-beta 1 loaded PLGA/fibrin gel constructs, BIOMATERIALS, 2010
15.   Chen, JL; Yin, Z; Shen, WLA; Chen, XA; Heng, BC; Zou, XAH; Ouyang, HW, Efficacy of hESC-MSCs in knitted silk-collagen scaffold for tendon tissue engineering and their roles, BIOMATERIALS, 2010
16.   Shen, WL; Chen, XA; Chen, JL; Yin, Z; Heng, BC; Chen, WS; Ouyang, HW, The effect of incorporation of exogenous stromal cell-derived factor-1 alpha within a knitted silk-collagen sponge scaffold on tendon regeneration, BIOMATERIALS, 2010
17.   Wang, W; Li, B; Li, YL; Jiang, YZ; Ouyang, HW; Gao, CY, In vivo restoration of full-thickness cartilage defects by poly(lactide-co-glycolide) sponges filled with fibrin gel, bone marrow mesenchymal stem cells and DNA complexes, BIOMATERIALS, 2010
18.   Zou, XH; Zhi, YL; Chen, X; Jin, HM; Wang, LL; Jiang, YZ; Yin, Z; Ouyang, HW, Mesenchymal stem cell seeded knitted silk sling for the treatment of stress urinary incontinence, BIOMATERIALS, 2010
19.   Yin, Z; Chen, X; Chen, JL; Shen, WL; Nguyen, TMH; Gao, L; Ouyang, HW, The regulation of tendon stem cell differentiation by the alignment of nanofibers, BIOMATERIALS, 2010
20.   Chen, X; Qi, YY; Wang, LL; Yin, Z; Yin, GL; Zou, XH; Ouyang, HW, Ligament regeneration using a knitted silk scaffold combined with collagen matrix, BIOMATERIALS, 2008
21.   Wu, YN; Yang, Z; Hui, JHP; Ouyang, HW; Lee, EH, Cartilaginous ECM component-modification of the micro-bead culture system for chondrogenic differentiation of mesenchymal stem cells, BIOMATERIALS, 2007
Book
1.        Tissue engineering cast, Vulnus\Burn and Regenerative medicine 2014.4
2.        Biological materials and Regeneration,Regenerative medicine:Basic and Clinical 2013
3.        Systematic anatomy 2015
 
Patents(authorized)
1.       Ouyang HW.Equipment and method of blood platelet enrichment (ZL200410026230.1,China,granted patents)
2.       Ouyang HW,Wang LL.Preparation of a kind of reticular tissue engineering scaffold (ZL200610051885.3,China,granted patents)
3.       Ouyang HW A novel cartilage tissue engineering scaffold and their application (ZL200710068762.5,China, granted patents)
5.       Ouyang HW A base on nano fiber tissue engineering scaffold and their application (ZL200810163691.1,China,granted patents)
7.       Ouyang HW,ZHAO HS,CHEN LK.Preparation and application of silk fibroin based integration bilayer subchondral bone scaffold (ZL201210411395.5,China)
8.       Ouyang HW,TAO JD.A orientation channel collagen scaffold preparation method and special device (ZL201310220030.9,China)
Research work

Sports medicine;Stem cells and regenerative medicine.