Profile

Working experience

1984-1994: Department of Physiology, Zhejiang Medical  College

1994-1998: Department of Physiology, Zhejiang Medical  University

1998-2009: Department of Physiology, Zhejiang University  School of Medicne

2009-present: Department of Pathophysiology, Zhejiang University School of Medicne, Professor

 

Publications

1)      Shen YL, Shi YZ, Chen GG, Wang LL, Zheng MZ, Jin HF, Chen YY. TNF-α induces Drp1 mitochondrial fragmentation during inflammatory cardiomyocyte injury. Int J Mol Med 2018;41(4):2317-2327.

2)      Chen YY, Sun ZW, Jiang JP, Kang XD, Wang LL, Shen YL, Xie XD, Zheng LR. alpha-adrenoceptor-mediated enhanced inducibility of atrial fibrillation in a canine system inflammation model. Mol Med Rep 2017;15(6):3767-3774.

3)      Zhang L, Geng WR, Hu J, Chen XM, Shen YL, Wang LL, Jiang JP, Chen YY. Lipopolysaccharide pretreatment promotes cardiac stem cell migration through heat shock protein 90-dependent β-catenin activation. Life Sci 2016: 153(5): 132-140 (IF 2.702, 5-year IF 2.670)

4)      Chen GG, Yan JB, Wang XM, Zheng MZ, Jiang JP, Zhou XM, Cai B, Shen YL. Mechanism of uncoupling protein 2‑mediated myocardial injury in hypothermic preserved rat hearts. Mol Med Rep 2016; 14(2): 1857-1864IF=1.5541

5)      Zhou HY, Zhang LN, Zheng MZ, Wang LL, Chen YY, Shen YL. Improved myocardial function with supplement of levosimendan to celsior solution. Journal of cardiovascular pharmacology. 2014;64(3):256-65.

6)      Chen N, Wang LL, Xue J, Ma XB, Zhao S, Rong RX, Li HQ, Ding L, Zheng MZ, Chen YY, Duan F, Shen YL. Different metabolic profiles of K1 serotype and non-serotype K1 and K2 Klebsiella pneumoniae isolates in oral infection mice model. Microbial pathogenesis. 2014;75:41-8

7)      Chen YY, Chen J, Hu JW, Yang ZL, Shen YL. Enhancement of lipopolysaccharide-induced toll-like receptor 2 expression and inflammatory cytokine secretion in HUVECs under high glucose conditions. Life Sci. 2013; 92(10):582-588.

8)      Chen YY, Chen J, Zhou XM, Meng XH, Jiang JP, Shen YL. Puerarin protects against high glucose-induced apoptosis by upregulating heme oxygenase-1 and inhibiting calpain activation in endothelial cells. Fund Clin Pharmacol 2012, 26(3):322-331

9)      Xu HJ, Chen WL, Wang Y, Zheng MZ, Chen YY, Shen YL. S262A mutation abolishes protective effects of connexin 43 against hypothermic preservation-induced injury in cardiomyocytes. J Heart Lung Transplant 2012, 31(6):663-669

10)    Chen YY, Chen J, Zhou XM, Meng XH, Jiang JP, Shen YL. Puerarin protects against high glucose-induced apoptosis by upregulating heme oxygenase-1 and inhibiting calpain activation in endothelial cells. Fund Clin Pharmacol  2012, 26(3):322-331

11)    Chen YY, Chen J, Zhou XM, Meng XH, Jiang JP, Shen YL. Puerarin protects against high glucose-induced apoptosis by upregulating heme oxygenase-1 and inhibiting calpain activation in endothelial cells. Fund Clin Pharmacol  2012, 26(3):322-331

12)    Zhang XW, Li WF, Li WW, Ren KH, Fan CM, Chen YY, Shen YL. Protective effects of the aqueous extract of Scutellaria baicalensis against acrolein-induced oxidative stress in cultured human umbilical vein endothelial cells. Pharm Biol 2011;49(3):256-61

13)    Chen YY, Zheng MZ, Lv PP, Hu L, Wang LL, Shen YL. Hydrogen peroxide regulates glucose-regulated protein 78 expression via a cyclooxygenase-2 dependent mechanism. J Biochem Mol Toxicol 2010;24(5):279-285.

14)    Yan ZK, Hu ZB, Pan XH, Chen YY, Zhang XM, Shen YL. Diazoxide supplemented Celsior solution improves hypothermic heart preservation effect in rat through activation of mitochondrial ATP-sensitive potassium channel. Pharmaceutical Biology. 2009, 47(11): 1060-1066.

15)    Wu PL, Lin GH, Kang XD, Yuan H, Shen YL. Complement activation by carotenoid derived aldehydes in cultured human vein epithelial cells. Phytother Res 2009, 23(12): 1696-1700.

16)    Chen N, Shao W, Lv PP, Zhang SL, Chen YY, Zhu L, Lu Y, Shen YL. Hemin-induced Erk1/2 activation and heme oxygenase-1 expression in human umbilical vein endothelial cells. Free Radical Research. 2007, 41(9):990-6

17)    Guo W, Chen N, Chen YY, Xia Q, Shen YL. Activation of Mitochondrial ATP-Sensitive Potassium Channel Contributes to Protective Effect in Prolonged Myocardial Preservation. Conf Proc IEEE Eng Med Biol Soc. 2005;4:4027-30

18)    Shen YL, Chen YY, Wu XD, Bruce IC, Xia Q. Activation of Mitochondrial ATP-Sensitive Potassium Channels Delays Ischemia-Induced Cellular Uncoupling in Rat Heart. Acta Pharmacol Sin. 2004, 25(1):22-28

19)    Cao CM, Xia Q, Chen YY, Zhang X, Shen YL. Opioid receptor-mediated effects of interleukin-2 on the [Ca2+]i transient and contraction in isolated ventricular myocytes of the rat. Pflugers Arch, 2002, 443(4): 635-42.


Research work

Mechanism and prevention of cardiac ischemia-reperfusion injury. Preclinical study on heart hypothermic preservation.

Contact

Phone:0571-88208250
E-mail:shenyueliang@gmail.com