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Id VisitTime IPAddress Area
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23217453 2018-05-13 42.236.49.107 中国
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23136414 2018-05-11 106.11.158.254 亚太地区
Weilin Hu

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Personal Information

Name:         Weilin Hu

Address:       Department of Medical Microbiology and Parasitology,

 Zhejiang University School of Medicine,

 Hangzhou, Zhejiang 310058, P.R. China

Phone:         +8613567144644

Email:         huweilin@zju.edu.cn  

 

Dr. Hu is a Lecturer in Department of Medical Microbiology and Parasitology, Zhejiang University School of Medicine. Her researches have been centered on the molecular and cellular mechanism of important pathogenic microorganism during infection, and the development of genetic engineering vaccine for important pathogenic microorganisms.

 

Professional Positions

2012.11-2013.5 Exchange PhD student and Staff, Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA. Adivisor: Prof. Frank X. Yang.

 

2014.7-2017.5  Postdoctoral fellow and Research assistant, Department of Medical Microbiology and Parasitology, Zhejiang University School of Medicine, Hangzhou, Zhejiang, P.R. China. Adivisor: Prof. Jie Yan.

 

2017.6-currect Lecturer and Research assistant, Department of Medical Microbiology and Parasitology, Zhejiang University School of Medicine, Hangzhou, Zhejiang, P.R. China. Adivisor: Prof. Jie Yan.

 

 

Publications

1.    Hu WL, Ge YM, Sun D, Dong HY, Yang XF, Yan J. p53-signaling controls cell cycle arrest and caspase-independent apoptosis in macrophages infected with pathogenic Leptospira species. Cell Microbiol. 2013,15(10):1624-1659.

2.    Hu WL, Pappas CJ, Zhang JJ, Yang YY, Yan J, Picardeau M, Yang XF. The EbpA-RpoN regulatory pathway of the pathogen Leptospira interrogans is essential for survival in the environment. Appl Environ Microbiol. 2017, 83(3). pii: AEM.02377-16.

3.    Hu WL, Dong HY, Li Y, Ojciusd DM, Li SJ, Yan J. Bid-Induced release of AIF/EndoG from mitochondria causes apoptosis of macrophages during infection with Leptospira interrogans. Front Cell Infect Mi. 2017, 7:471.

4.    Hu WL, Xu’ai Lin, Yan J. Leptospire and leptospirosis in China. Curr Opin Infect Dis. 2014, 27(5):432-436.

5.    Dong SL*, Hu WL*(co-first author), Ge YM, Ojcius DM, Zhao JF, Lin XA, Li LJ, Yan J. A leptospiral proteasome, HslUV, contributes to the intracellular survival of Leptospira interrogans in hosts and the transmission of leptospirosis. Emerg Microbes Infec. 2017, 6(11):e105.

6.    Kassegne K*, Hu WL*(co-first author), Ojcius DM, Sun D, Ge YM, Yang XF, Li LJ, Yan J. Identification of collagenase as a critical virulence factor for invasiveness and transmission of pathogenic Leptospira species. J Infect Dis. 2014,209(7):1105-1115.

7.    Hua CZ*, Hu WL*(co-first author), Shang SQ, Li JP, Hong LQ, Yan J. Serum concentrations of antibodies against outer membrane protein P6, Protein D and their T- and B-cell combined antigenic epitopes of nontypeable Haemophilus influenzae in Children and adults of different ages. Clin Vaccine Immunol. 2015, 23(2):155-161.

8.    Xue F, Dong HY, Wu JY, Wu ZW, Hu WL, Sun AH, Troxell B, Yang XF, Yan J. Transcriptional responses of Leptospira interrogans to host innate immunity: Significant changes in metabolism, oxygen tolerance, and outer membrane. PLoS Negl Trop Dis, 2010, 4: e857.

9.    Komi KK, Ge YM, Xin XY, Ojcius DM, Sun D, Hu WL, Zhao X, Lin X, Yan J. ChpK and MazF of the toxin-antitoxin modules are involved in the virulence of Leptospira interrogans during infection. Microbes Infect. 2015,17(1):34-47.

10. Li S, Li P, Zhang L, Hu WL, Wang M, Liu Y, Tang G, Wang D, Zhou B, Yan J. The role of reactive oxygen intermediates in the intracellular fate of Leptospira interrogans in the macrophages of different hosts. PLoS One. 2017;12(6):e0178618.

11. Chen X, Li SJ, Ojcius DM, Sun AH, Hu WL, Lin X, Yan J. Mononuclear-macrophages but not neutrophils act as major infiltrating anti-leptospiral phagocytes during leptospirosis. PLoS One. 12(7):e0181014.


Research work

Dr. Hu is a Lecturer in Department of Medical Microbiology and Parasitology, Zhejiang University School of Medicine. Her researches have been centered on the molecular and cellular mechanism of important pathogenic microorganism during infection, and the development of genetic engineering vaccine for important pathogenic microorganisms.