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张红河

性别:男
职称:副教授
单位:医学院

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张红河

个人简介

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学习经历:

20006     中南大学湘雅医学院医学检验系              学士

200612    温州医学院医学检验系                 硕士

20123      浙江大学医学院病理学系                         博士

  

工作经历:

20007-20085        杭州市第一人民医院       技师、主管技师

20126-201512      浙江大学基础医学院       讲师

20131-20134        德国慕尼黑大学医学院    访问学者

201312-201412    美国威斯康星医学院        博士后     

20157-20158        美国威斯康星医学院        访问学者

201512月至今                 浙江大学基础医学院         副教授

  

发表论文:

1. Huang D, Sun W, Zhou Y, Li P, Chen F, Chen H, Xia D, Xu E, Lai M, Wu Y, Zhang H*. Mutations of key driver genes in colorectal cancer progression and metastasis. Cancer Metastasis Rev. 2018 Mar;37(1):173-187. 

2. Wan L, Yu W, Shen E, Sun W, Liu Y, Kong J, Han F, Zhang L, Yu T, Zhou Y, Xie S, Xu E, Zhang H*, Lai M*. SRSF6-Regulated Alternative Splicing that Promotes Tumor Progression Offers a Therapy Target for Colorectal Cancer. GUT, 2017, in press. 

3. Zhang H#, Lu Y, Chen E, Li X, Lv B, Vikis HG,Liu P. XRN2 promotes EMT and metastasis through regulating maturation of miR-10a. Oncogene. 2017, 36(27):3925-3933. 

4. Lu W#, Zhang H# (Co-First), Niu Y, Wu Y, Sun W, Li H, Kong J, Ding K, Shen HM, Wu H, Xia D*, Wu Y*. Long non-coding RNA linc00673 regulated non-small cell lung cancer proliferation, migration, invasion and epithelial mesenchymal transition by sponging miR-150-5p. Mol Can, 2017;16(1):118 .

5. Wang X, Zhang L, Li H, Sun W, Zhang H*, Lai M*. THBS2 is a Potential Prognostic Biomarker in Colorectal Cancer. Sci Rep. 2016, 6:33366.

6. Kong J, Sun W, Li C, Wan L, Wang S, Wu Y, Xu E, Zhang H*, Lai M*. Long non-coding RNA LINC01133 inhibits epithelial-mesenchymal transition and metastasis in colorectal cancer by interacting with SRSF6. Cancer Lett. 2016,380(2):476-84. IF 6.375

7. Wan L, Kong J, Tang J, Wu Y, Xu E, Lai M*, Zhang H*. HOTAIRM1 as a potential biomarker for diagnosis of colorectal cancer functions the role in the tumour suppressor. J Cell Mol Med. 2016, 20(11):2036-2044.

8. Li C, Wang X, Casal I, Wang J, Li P, Zhang W, Xu E, Lai M*, Zhang H*. Growth differentiation factor 15 is a promising diagnostic and prognostic biomarker in colorectal cancer. J Cell Mol Med. 2016, 20(8): 1420-6.

9. Tang J, Li Y, Wang J, Wen Z, Lai M, Zhang H*. Molecular mechanisms of microRNAs in regulating epithelial-mesenchymal transitions in human cancers. Cancer Lett. 2016, 371(2):301-13.

10. Li C, Wang J, Kong J, Tang J, Wu Y, Xu E, Zhang H*, Lai M*. GDF15 promotes EMT and metastasis in colorectal cancer. Oncotarget. 2016 Jan 5;7(1):860-72. 
11. Wang J, Li W, Wang Y, Li C, Ding M, Zhang H*, Lai M*. The H6D genetic variation of GDF15 is associated with genesis, progress and prognosis in colorectal cancer. Pathol Res Pract, 2015, 211(11):845-50. 

12. Zhang H, Tang J, Li C, Kong J, Wang J, Wu Y, Xu E, Lai M. MiR-22 regulates 5-FU sensitivity by inhibiting autophagy and promoting apoptosis in colorectal cancer cells. Cancer Lett. 2015, 356:781-90.

13. Li P, Wu H, Zhang H, Shi Y, Xu J, Ye Y, Xia D, Yang J, Cai J, Wu Y. Aspirin use after diagnosis but not prediagnosis improves established colorectal cancer survival: a meta-analysis. Gut. 2015, 64(9):1419-25.

14. Wang J, Tang J, Lai M*, Zhang H*. 5-Hydroxymethylcytosine and disease. Mutat Res Rev Mutat Res. 2014, 762C:167-175.

15. Zhang H, Li P, Ju H, Pesta M, Kulda V, Jin W, Cai M, Liu C, Wu H, Xu J, Ye Y, Zhang G, Xu E, Cai J, Lai M, Xia D, Yang J, Wu Y. Diagnostic and Prognostic Value of microRNA-21 in Colorectal Cancer: An Original Study and Individual Participant Data Meta-analysis. Cancer Epidemiol Biomarkers Prev. 2014, 23(12):2783-92.

16. Li P*, Zhang H*(Co-first author), Chen J, Shi Y, Cai J, Yang J, Wu Y. Association between dietary antioxidant vitamins intake/blood level and risk of gastric cancer. Int J Cancer. 2014, 135(6):1444-53.

17. Zhang H, Li Y, Huang Q, Ren X, Hu H, Sheng H, Lai M. MiR-148a promotes apoptosis through targeting Bcl-2 in colorectal cancer. Cell Death Differ .2011,18(11): 1702-1710.

18.Zhang H, Li Y, Lai M. The microRNA network and tumor metastasis. Oncogene. 2010, 29(7):937-48.  

 

专利:

1.  来茂德,张红河,一种人小RNA-148a表达载体及应用,2012.1.4-2032.1.3,中国发明专利,ZL201010161597.X。已授权

2. 张红河,孔建鲁,来茂德,一种靶向SRSF6的慢病毒干扰载体的构建及其在结直肠癌治疗中的应用,中国发明专利,CN201510268810.X已公开

 

科研项目:

(1) 长链非编码RNA LINC00152在结直肠癌转移中的作用机制研究 (项目负责人), 69.6万元, 2017.1--2020.12,在研,项目编号:81672730

(2) 长链非编码RNA HOTAIRM1在结直肠癌中的功能研究 (项目负责人),国家自然科学青年基金,23万元,2013.01-2015.12结题,项目编号: 81201557

(3) 长链非编码RNA TTANR调控结直肠癌细胞EMT的机制研究(项目负责人),浙江省自然科学基金面上项目,10万元,2015.01-2017.12在研,项目编号: LY15H160032

(4) S100A2在结直肠癌中的作用及其机制研究(项目负责人),21万,2017.1-2018.12,中央高校基金科研发展专项,在研2017FZA7005

(5) TTNAR在结直肠癌中的作用及其机制研究(项目负责人),10万,2016.1-2016.12,中央高校基本科研业务费专项资金,结题,

(6) MiR-148a在结直肠癌中的调控网络及生物学功能研究(参与),国家自然科学基金面上项目,60万元,2012.01-2015.12,在研,项目编号: 81171938

(7) 长链非编码RNA linc01133在结直肠癌细胞可塑性中的作用机制研究(参与),国家自然科学基金面上项目,74.4万元2016.01-2019.12在研,项目编号:81572716

 

 

 

工作研究领域

分子病理学

联系方式

电话:0571-88208199
电子信箱:honghezhang@zju.edu.cn