靳明亮，浙江大学百人计划研究员，博士生导师。国家自然科学基金优秀青年基金获得者，中国畜牧兽医学会动物营养学分会副秘书长，入选全国农业科研杰出人才培养计划及全球前2%顶尖科学家年度科学影响力排行榜，获颐和青年创新奖和中国畜牧兽医学会“第四届井冈新秀”荣誉称号。主要从事肠道微生物与肠道免疫营养调控、免疫调节肽与益生菌等抗生素替代品研发等。主持国家重点研发计划项目、国家自然科学基金、国际科学基金、浙江省自然科学基金重点项目等课题二十余项；以第一或通讯作者在Science Advances、Journal of Advanced Research、Carbohydrate Polymers等期刊发表SCI论文40余篇，发表ESI高被引论文4篇，论文总被引用5700余次，H因子39。以主要参与人获神农中华农业科技一等奖及陕西省科技进步二等奖各1项。

1.    教育经历

2006.09-2011.06:   博士研究生，浙江大学，动物营养与饲料科学

2002.09-2006.06:   学士，南京农业大学，动物科学

2.    工作经历

2020.08-至今:          百人计划研究员，浙江大学

2019.05-2020.07:   特聘研究员，浙江大学

2014.05-2019.04:    副教授，西北工业大学

2018.07-2018.08:    访问学者，加拿大阿尔伯塔大学

2015.09-2017.02:    访问学者，加拿大阿尔伯塔大学

2013.07-2014.04:    讲师，西北工业大学

2011.07-2013.06:    博士后，西北工业大学

2011.07-2011.08:    访问学者，美国密苏里州立大学哥伦比亚分校

主讲：

1. 动物性食品安全（本科生）

2. 分子生物学实验（研究生）

3. 现代农业创新与乡村振兴战略（研究生）

参讲：

1. 猪文化与人类健康（本科生慕课课程）

1. 国家重点研发计划项目：新型饲用免疫调节肽创制，2023-2028，主持。

2. 国家自然科学基金优秀青年科学基金：猪消化道微生物与碳水化合物代谢，2021-2023，主持。

3. 国家自然科学基金面上项目：基于益生活性的猪结肠菌群对阿拉伯木聚糖的动态响应机制研究，2024-2027，主持。

4. 国家自然科学基金青年基金：白术多糖对断奶应激诱导肠粘膜屏障损伤的调控作用及机制研究，2018-2020，主持。

5. 国家重点研发计划子课题：发酵糟粕饲料的研发及在母猪上的应用技术研究，2022-2027，主持。

6. 农业科研杰出人才培养计划，2021-2022，主持。

7. 浙江省自然科学基金重点项目：基于益生活性的仔猪结肠菌群对不同类型膳食纤维的动态响应机制研究，2020-2023，主持。

8. 浙江大学启真计划：猪呼吸功能障碍的肠道微生物机制及营养调控，2022-2023，主持。

9. 浙江大学领航计划：金华母猪繁殖性能的肠道微生物机制及营养调控研究，2024-2025，主持。

10. 浙江大学基本科研业务费专项资金青年科研创新专项：肠道菌群在木耳多糖干预高脂诱导肥胖中的作用及机制研究，2020-2021，主持。

11. 浙江大学“以民促J”基础培育计划项目：****对肠道屏障功能的影响及肠道微生物机制研究，2021.3-2021.12，主持。

12. 浙江大学百人计划科研启动经费，2021-2025，主持。

13. 横向课题：不同生理状态动物肠道菌群的营养调控研究，2023-2027，主持。

14. 横向课题：断奶幼龄动物肠道菌群的营养调控研究，2021-2022，主持。

15. 陕西省自然科学基金面上项目： 基于微生物区系研究模拟失重对肠黏膜屏障功能的影响，2017-2018，主持。

16. 国际科学基金：Preparation, structural characterization and antiviral activities of sulfated polysaccharides from Astragalus membranaceus，2012-2014，主持。

17. 中国博士后科学基金特别资助项目：基于Toll样受体通路研究模拟失重对肠道免疫功能的影响，2013-2014，主持。

18. 中国博士后科学基金面上项目：模拟微重力环境下灵芝多糖硫酸酯化衍生物对肠道免疫功能的调控及其机理研究，2011-2013，主持。

19. 中央高校基本科研业务费科研资助项目：白术多糖对模拟失重诱导肠黏膜屏障功能障碍的调控作用及机制研究，2017-2018，主持。

20. 中央高校基本科研业务费科研资助项目：肠道微生态在模拟失重诱导肠黏膜损伤中的作用及机制研究，2014-2016，主持。

发表学术论文:

[1].    Wang, C., Zhang, Y., Wei, S.Y., Fu, L.L., Wang, Y.Z., & Jin, M.L.* Bioconversion of soybean meal into gut microbiota-targeting polysaccharides via fermentation by Bacillus subtilis. Journal of Cleaner Production. 2024, 142787.

[2].    Zong, X., Luo, S.Q., Liu, S.Q., Deehan, E.C., Wang, Y.Z., & Jin, M.L.* Nondigestible carbohydrates and gut microbiota: A dynamic duo in host defense. Animal Nutriomics. 2024, 1, e7.

[3].    Xu, B.C., Shaoyong, W.K., Wang, L., Yang, C., Chen, T.J., Jiang, X., Zhang, P., Jin, M.L.*, Wang, Y.Z.* Gut-targeted nanoparticles deliver specifically targeted antimicrobial peptides against Clostridium perfringens infections. Science Advances. 2023, 9(39), eadf8782.

[4].    Zong, X., Zhang, H., Zhu, L.Y., Deehan, E.C., Fu, J., Wang, Y.Z., Jin, M.L.* Auricularia auriculapolysaccharides attenuate obesity in mice through gut commensal Papillibacter cinnamivorans. Journal of Advanced Research. 2023, 52, 203-218.

[5].    Shaoyong, W.K., Jin, H.L., Jiang, X., Xu, B.C., Liu, Y.L., Wang, Y.Z., Jin, M.L.* Benzo [a] pyrene-loaded aged polystyrene microplastics promote colonic barrier injury via oxidative stress-mediated notch signalling. Journal of Hazardous Materials. 2023, 457, 131820.

[6].    Wen, C.Y., Zhang, H., Guo, Q.P., Duan, Y.H., Chen, S.S., Han, M.M., Li, F.N., Jin, M.L.*, Wang, Y.Z.* Engineered Bacillus subtilis alleviates intestinal oxidative injury through Nrf2-Keap1 pathway in enterotoxigenic Escherichia coli (ETEC) K88-infected piglet. Journal of Zhejiang University-Science B.2023, 24 (6), 496-509.

[7].    He, H., Yang, M.Z., Li, W.T., Lu, Z.Q., Wang, Y.Z., Jin, M.L.* Fecal microbial and metabolic characteristics of swine from birth to market. Frontiers in Microbiology. 2023, 14, 1191392

[8].    Chen, N.N., Liu, Y.L., Zong, X., Zhou, G.L., Lu, Z.Q., Wang, F.Q., Wang, Y.Z., Jin, M.L.* Dynamic changes of inulin utilization associated with longitudinal development of gut microbiota. International Journal of Biological Macromolecules. 2023, 229, 952-963.

[9].    Wei, S.Y., Wang, C., Zhang, Q.F., Yang, H., Deehan, E.C., Zong, X., Wang, Y.Z., Jin, M.L.* Dynamics of microbial communities during inulin fermentation associated with the temporal response in SCFA production. Carbohydrate Polymers. 2022, 298, 120057.

[10]. Wei, S.Y., Wang, J.J., Wang, C., Wang, Y.Z., Jin, M.L.* Inulin mitigates high fructose-induced gut dysbiosis and metabolic dysfunction in mice. Journal of Functional Foods. 2022, 97, 105236.

[11]. Wang, C., Wei, S.Y., Chen, N.N., Xiang, Y., Wang, Y.Z., Jin, M.L.* Characteristics of gut microbiota in pigs with different breeds, growth periods and genders. Microbial Biotechnology. 2022, 15(3), 793-804.

[12]. Kai, L.X., Zong, X., Jiang, Q., Lu, Z.Q., Wang, F.Q., Wang, Y.Z., Wang, T.H.*, Jin, M.L.* Protective effects of polysaccharides from Atractylodes macrocephalae Koidz. against dextran sulfate sodium induced intestinal mucosal injury on mice. International Journal of Biological Macromolecules. 2022, 195, 142-151.

[13]. Shaoyong, W.K., Liu, Y.L., Xu, B.C., Pan, B., Xianmi, X., Wang, Y.Z., Jin, M.L.* Exposure to BDE-47 causes female infertility risk and induces oxidative stress and lipotoxicity-mediated ovarian hormone secretion disruption in mice. Science of The Total Environment. 2022, 842, 156885.

[14]. Su, W.F., Jiang, Z.P., Wang, C., Xu, B.C., Lu, Z.Q.*, Wang, F.Q., Zong, X., Jin, M.L.*, Wang, Y.Z.* Dynamics of defatted rice bran in physicochemical characteristics, microbiota and metabolic functions during two-stage co-fermentation. International Journal of Food Microbiology. 2022, 362, 109489.

[15]. Wen, C.Y., Wei, S.Y., Zong, X., Wang, Y.Z.*, Jin, M.L.* Microbiota-gut-brain axis and nutritional strategy under heat stress. Animal Nutrition. 2021, 7, 1329-1336. 

[16]. Jiang, Z.P., Li, W.T., Su, W.F., Wen, C.Y., Gong, T., Zhang, Y., Wang, Y.Z.*, Jin, M.L.*, Lu, Z.Q.* Protective Effects of Bacillus amyloliquefaciens 40 against Clostridium perfringens infection in mice. Frontiers in Nutrition. 2021, 8, 733591.

[17]. Wen, C.Y., Li, S.Y., Wang, J.J., Zhu, Y.M., Zong, X., Wang, Y.Z., Jin, M.L.* Heat stress alters the intestinal microbiota and metabolomic profiles in mice. Frontiers in Microbiology. 2021, 12, 706772.

[18]. Zong, X., Cheng, Y.Z., Xiao, X., Fu, J., Wang, F.Q., Lu, Z.Q., Wang, Y.Z., Jin, M.L.* Protective effects of sulfated polysaccharide from Enterobacter cloacae Z0206 against DSS-induced intestinal injury via DNA methylation. International Journal of Biological Macromolecules. 2021, 183: 861-869.

[19]. Zong, X., Xiao, X., Kai, L.X., Cheng, Y.Z., Fu, J., Xu, W., Wang, Y.Z., Zhao, K., Jin, M.L.* Atractylodis macrocephalae polysaccharides protect against DSS-induced intestinal injury through a novel lncRNA ITSN1-OT1. International Journal of Biological Macromolecules. 2021, 167: 76-84.

[20]. Su, W., Jiang, Z.P, Hao, L.H., Li, W.T., Gong, T., Zhang, Y., Wang, C., Lu, Z.Q.*, Jin, M.L.*, Wang, Y.Z.* Variations of soybean meal and corn mixed substrates in physicochemical characteristics and microbiota during two-stage solid-state fermentation. Frontiers in Microbiology. 2021, 12: 1856.

[21]. Xu, B.C., Fu, J., Qiao, Y., Cao, J.P., Deehan, E.C., Li, Z., Jin, M.L.*, Wang, X.X.*, Wang, Y.Z.* Higher intake of microbiota-accessible carbohydrates and improved cardiometabolic risk factors: a meta-analysis and umbrella review of dietary management in patients with type 2 diabetes. American Journal of Clinical Nutrition. 2021, 113(6): 1515-1530.

[22]. Zong, X., Fu, J., Xu, B.C., Wang, Y.Z., Jin, M.L.* Interplay between gut microbiota and antimicrobial peptides. Animal Nutrition. 2020, 6: 389-396.

[23]. Chen, N.N.#, Zhang, H. #, Zong, X., Li, S.Y., Wang, J.J., Wang, Y.Z., Jin, M.L.* Polysaccharides from Auricularia auricula: Preparation, structural features and biological activities. Carbohydrate Polymers. 2020, 247: 116750.

[24]. Chen, N.N.#, Zhao, X.Y.#, Wang, F.Q., Lu, Z.Q., Wang, Y.Z., Jin, M.L.* Proteomic study of sulfated polysaccharide from Enterobacter cloacae Z0206 against H₂O₂-induced oxidative damage in murine macrophages. Carbohydrate Polymers. 2020, 237: 116147.

[25]. Xu, B.C., Fu, J., Zhu, L.Y., Li, Z., Wang, Y.Z., Jin, M.L.* Overall assessment of antimicrobial peptides in piglets: a set of meta-analyses. Animal. 2020, 1-9.

[26]. Xu, B.C., Zhu, L.Y., Fu, J., Li, Z., Wang, Y.Z., Jin, M.L.* Overall assessment of fermented feed for pigs: a series of meta-analyses. Journal of Animal Science. 2019, 12: 4810-4821.

[27]. Jin, M.L., Wang, J.J., Zhang, H., Zhou, H.B., Zhao, K.* Simulated weightlessness perturbs the intestinal metabolomic profile of rats. Frontiers in Physiology, 2019, 10: 1279.

[28]. Jin, M.L., Kalainy, S., Baskota, N., Chiang, D., Deehan, E.D., McDougall, C., Tandon, P., Martínez, I., Cervera, C., Walter, J.*, Abraldes, J.G.* Faecal microbiota from patients with cirrhosis has a low capacity to ferment non-digestible carbohydrates into short chain fatty acids. Liver International. 2019, 39: 1437-1447.

[29]. Jin, M.L., Zhang, H., Wang, J.J., Shao, D.Y., Yang, H., Huang, Q.S., Shi, J.L., Xu, C.L.*, Zhao, K.*Response of intestinal metabolome to polysaccharides from mycelia of Ganoderma lucidum. International Journal of Biological Macromolecules. 2019, 122: 723-731.

[30]. Jin, M.L., Zhang, H., Zhao, K., Xu, C.L., Shao, D. Y., Huang, Q.S., Shi, J.L., Yang, H.* Responses of intestinal mucosal barrier functions of rats to simulated weightlessness. Frontiers in Physiology. 2018, 9: 729.

[31]. Jin, M.L.*, Zhu, Y.M., Shao, D.Y., Zhao, K., Xu, C.L., Li, Q., Yang, H., Huang, Q.S., Shi, J.L. Effects of polysaccharide from mycelia of Ganoderma lucidum on intestinal barrier functions of rats. International Journal of Biological Macromolecules. 2017, 94: 1-9.

[32]. Xu, C.L.*, Guo, Y., Qiao, X.J., Shang, X.Y., Niu, W.N., Jin, M.L.* Design, recombinant fusion expression and biological evaluation of vasoactive intestinal peptide analogue as novel antimicrobial agent. Molecules. 2017, 22: 1963.

[33]. Zhao, K.#, Jin, M.L.#, Chen, Q., Zheng, P.S.* Polysaccharides produced by Enterobacter cloacae induce apoptosis in cervical cancer cells. International Journal of Biological Macromolecules. 2015, 72: 960-964.

[34]. Jin, M.L., Wang, Y.M., Huang, M., Lu, Z.Q., Wang, Y.Z.* Sulphation can enhance the antioxidant activity of polysaccharides produced by Enterobacter cloacae Z0206. Carbohydrate Polymers. 2014, 99: 624-629.

[35]. Jin, M.L., Zhao, K., Huang, Q.S., Shang, P.* Structural features and biological activities of the polysaccharides from Astragalus membranaceus. International Journal of Biological Macromolecules. 2014, 64: 257-266.

[36]. Jin, M.L., Huang, Q.S., Zhao, K., Shang, P.* Biological activities and potential health benefit effects of polysaccharides isolated from Lycium barbarum L. International Journal of Biological Macromolecules. 2013, 54: 16-23.

[37]. Jin, M.L., Zhao, K., Huang, Q.S., Shang, P.* Preparation, structure and biological activities of exopolysaccharides produced by Enterobacter cloacae. Asian Journal of Chemistry. 2013, 25: 9101-9104.

[38]. Jin, M.L., Zhao, K., Huang, Q.S., Xu, C.L., Shang, P.* Isolation, structure and bioactivities of the polysaccharides from Angelica sinensis (Oliv.) Diels: A review. Carbohydrate Polymers. 2012, 89: 713-722.

[39]. Jin, M.L., Lu, Z.Q., Huang, M., Wang, Y.M., Wang, Y.Z.* Effect of Se-enriched polysaccharides produced by Enterobacter cloacae Z0206 on alloxan-induced diabetic mice. International Journal of Biological Macromolecules. 2012, 50: 348-352.

[40]. Jin, M.L., Lu, Z.Q., Huang, M., Wang, Y.M., Wang, Y.Z.* Sulfated modification and antioxidant activity of exopolysaccahrides produced by Enterobacter cloacae Z0206. International Journal of Biological Macromolecules. 2011, 48: 607-612.

[41]. Jin, M.L., Wang, Y.M., Huang, M., Lu, Z.Q., Wang, Y.Z.* Optimization of culture medium for exo-polysaccharide production by Enterobacter cloacae Z0206 using response surface methodology. Asian Journal of Chemistry. 2011, 23: 3799-3802.

[42]. Jin, M.L., Wang, Y.M., Xu, C.L., Lu, Z.Q., Huang, M., Wang, Y.Z.* Preparation and biological activities of an exopolysaccharide produced by Enterobacter cloacae Z0206. Carbohydrate Polymers. 2010, 81: 607-611.

发表会议论文或摘要：

[1].    Jin, M.L., Deehan, E., Baskota, N., Kalainy, S., Chiang, D., McDougall, C., Tandon, P., Cervera, C., Martinez, I., Walter, J.*, Abraldes, J.G.* Fecal microbiotas from patients with cirrhosis show a low capacity for short chain fatty acids production. Hepatology. 2018, 68: 143A-144.

[2].    Jin, M.L., Shang, P. Effects of simulated weightlessness on the intestinal mucosal barrier functions of rats. Proceeding of the 19^th International Academy of Astronautics (IAA) Humans in Space. Jul. 2013. Cologne, Germany.

[3].    Jin, M.L., Wang, Y.M., Lu, Z.Q., Huang, M., Xu, C.L., Wang, Y.Z. Isolation, characterization and antioxidant activity of an exopolysaccharide produced by Enterobacter cloacae Z0206. Proceedings of ADSA-CSAS-ASAS Joint Annual Meeting. Jul. 2010. Denver, USA.

[4].    Jin, M.L., Wang, Y.Z., Yang, X.Q., Xu, C.L., Lu, Z.Q. Protective effect of polysaccharide produced by Enterobacter cloacae Z0206 on cyclophosphamide-induced suppression of immune functions in mice. Proceedings of ADSA-CSAS-ASAS Joint Annual Meeting. Jul. 2009. Montreal, Canada.

[5].    Jin, M.L., Wang, Y.Z., Xu, C.L., Yang, X.Q. Effect of enriched-Selenium exopolysaccharide and exopolysaccharide produced by Enterobacter cloacae Z0206 on immune function of immunosuppressed mice. Proceeding of the 13th Animal Science Congress of the Asian-Australasian Association of Animal Production Societies. Sep. 2008. Hanoi, Vietnam.

参编著作：

[1]. 《现代动物分子营养学》，科学出版社，2023，参编。

[2]. 《动物科学专业导论》，中国农业出版社，2023，参编。

[3]. 《生猪养殖替抗指南》，中国农业出版社，2022，参编。

[4]. 《动物分子营养学》，浙江大学出版社，2020，参编。

[5]. 《犬行为、营养与健康》，中国农业科学技术出版社，2024，主译。

[6].   Deehan, E.C., Duar, R.M., Armet, A.M., Perez-Muñoz, M.E., Jin, M., Walter, J. Chapter 20: Modulation of the gastrointestinal microbiome with nondigestible fermentable carbohydrates to improve human health. Bugs as Drugs: Therapeutic Microbes for the Prevention and Treatment of Disease. ASM Press, 2018.

[7]. 《人类极端环境生理学》，科学出版社，2017，参译。