Biosketch:

1991-96 PhD, Molecular Genetics and Microbiology, Rutgers University (Supervisor: Richard Ebright）

1996-99 Irvington Postodoc Fellow of Molecular Immunology, Massachusetts Institute of Technology (Mentor: Phillip Sharp)  

2000      Senior Scientist, Dupont Pharmaceuticals Company

2000-05 Professor, Insitute of Microbiology, Chinese Academy of Sciences

2005-12 Professor, Institute of Biophysics, Chinese Academy of Sciences

2012-15 Professor, Wuhan Institute of Virology, Chinese Academy of Sciences

2016-22 Professor, Institut Pasteur of Shanghai, Chinese Academy of Sciences

2022-     Professor, Zhejiang University Medical School

Selected publications on regulation of immunopathogenesis：

1.      Kang X, Xu Y, Wu X, Liang Y, Wang C, Guo J, Wang Y, Chen M, Wu D, Wang Y, Bi S, Qiu Y, Lu P, Cheng J, Xiao B, Hu L, Gao X, Liu J, Wang Y, Song Y, Zhang L, Suo F, Chen T, Huang Z, Zhao Y, Lu H, Pan C and Tang H (2005) Proteomic Fingerprints for Potential Application to Early Diagnosis of Severe Acute Respiratory Syndrome. Clin Chem 51(1): 56-64.

2.      Weng C, Li Y, Xu D, Shi Y, Tang H (2005) Specific cleavage of Mcl-1 by caspase-3 in TRAIL-induced apoptosis in Jurkat leukemia T cells. J Biol Chem, 280:(11) 10491–10500.

3.      Perry AK, Chen G, Zheng DH, Tang H and Cheng G (2005) The host type I interferon response to viral and bacterial infections. Cell Res, 15(6):407-422.

4.      Kim K, Zhao J, Auh S, Yang X, Du P, Tang H*, and Fu Y* (2007) Adaptive immune cells temper initial innate responses. Nature Med 13(10):1248-1252 (*co-correspondence).

5.      Pan L, Chen S, Weng C, Call G, Zhu D, Tang H, Zhang N and Xie T (2007) Stem Cell Aging Is Controlled Both Intrinsically and Extrinsically in the Drosophila Ovary. Cell Stem Cell, 1:458-469.

6.      Zhao J, Kim KD, Yang X, Auh S, Fu YX* and Tang H* (2008) Hyper innate responses in neonates lead to increased morbidity and mortality after infection. Proc Natl Acad Sci U S A 105(21):7528-33 (*co-correspondence).

7.      Zheng D, Chen G, Guo B, Cheng G* and Tang H* (2008) PLP2, a potent deubiquitinase from murine hepatitis virus, strongly inhibits cellular type I interferon production. Cell Res, 18:1105–13 (*co-correspondence).

8.      Zhao J, Yang X, Kim KD, Auh S, Fu YX* and Tang H* (2009) Do adaptive immune cells suppress or activate innate immunity? Trends Immunol. 30(1):8-12 (*co-correspondence).

9.      Li X, Yang X, Xu Y, Jiang X, Li X, Nan F, Tang H. (2009) Troglitazone inhibits cell proliferation by attenuation of epidermal growth factor receptor signaling independent of peroxisome proliferator-activated receptor gamma. Cell Res. 19(6):669-71.

10.    Mi Z, Fu J, Xiong Y and Tang H. (2010) SUMOylation of RIG-I positively regulates the type I interferon signaling. Protein Cell, 1(3):275-283.

11.    Jiang J, Tang H. (2010) Mechanism of inhibiting type I interferon induction by hepatitis B virus X protein. Protein Cell. 1(12):1106-17.

12.    Da Q, Yang X, Xu Y, Gao G, Cheng G, Tang H. (2011) TANK-Binding Kinase 1 Attenuates PTAP-Dependent Retroviral Budding through Targeting Endosomal Sorting Complex Required for Transport-I. J Immunol. 186(5):3023-30 (Epub 2011 Jan 26).

13.    Upadhyay V, Poroyko V, Kim T, Devkota S, Fu S, Liu D, Tumanov AV, Koroleva EP, Deng L, Nagler C, Chang EB, Tang H & Fu YX (2012) Lymphotoxin regulates commensal responses to enable diet-induced obesity. Nature Immunol 13(10):947-53.

14.    Wu A, Su C, Wang D, Peng Y, Liu M, Hua S, Li T, Gao GF, Tang H, Chen J, Liu X, Shu Y, Peng D, Jiang T.(2013) Sequential reassortments underlie diverse influenza H7N9 genotypes in China. Cell Host Microbe.14(4):446-52.

15.    Wang XX, Ying P, Diao F, Wang Q, Ye D, Jiang C, Shen N, Xu N, Chen WB, Lai SS, Jiang S, Miao XL, Feng J, Tao WW, Zhao NW, Yao B, Xu ZP, Sun HX, Li JM, Sha JH, Huang XX, Shi QH, Tang H, Gao X, Li CJ. (2013) Altered protein prenylation in Sertoli cells is associated with adult infertility resulting from childhood mumps infection. J Exp Med.210(8):1559-74.

16.    Ma F, Feng J, Zhang C, Li Y, Qi G, Li H, Wu Y, Fu Y, Zhao Y, Chen H, Du J, Tang H. (2014) The requirement of CD8+ T cells to initiate and augment acute cardiac inflammatory response to high blood pressure. J Immunol, 192(7):3365-73

17.    Chen J, Zhao Y, Zhang C, Chen H, Feng J, Chi X, Pan Y, Du J, Guo M, Cao H, Chen H, Wang Z, Pei R, Wang Q, Pan L, Niu J, Chen X, Tang H. (2014) Persistent hepatitis C virus infections and hepatopathological manifestations in immune-competent humanized mice. Cell Res. Sep;24(9):1050-66.

18.    Yang Z, Du J, Chen G, Zhao J, Yang X, Su L, Cheng G, Tang H. (2014) Coronavirus MHV-A59 infects the lung and causes severe pneumonia in C57BL/6 mice. Virol Sin. 29(6):393-402

19.    Pan L, Wang S, Lu T, Weng C, Song X, Park JK, Sun J, Yang ZH, Yu J, Tang H, McKearin DM, Chamovitz DA, Ni J, Xie T. (2014) Protein competition switches the function of COP9 from self-renewal to differentiation. Nature. 514(7521):233-6.

20.    Yang Y and Tang H. (2016) Aberrant coagulation causes a hyper-inflammatory response in severe influenza pneumonia. Cell Mol Immunol. 13(4):432-42.

21.    X He, J Yu, M Wang, Y Cheng, Y Han, S Yang, G Shi, L Sun, Y Fang, S Gong, Z Wang, YX Fu, L Pan and H Tang (2017) Bap180/Baf180 is required to maintain homeostasis of intestinal innate immune response in Drosophila and mice. Nature Microbiology, 2:17056

22.    Zhang C, Feng J, Du J, Zhuo Z, Yang S, Zhang W, Wang W, Zhang S, Iwakura Y, Meng G, Fu YX, Hou B, Tang H.(2017) Macrophage-derived IL-1α promotes sterile inflammation in a mouse model of acetaminophen hepatotoxicity. Cell Mol Immunol. doi: 10.1038/cmi.2017.22.

23.    Fu W, Liu X, Lin X, Feng H, Sun L, Li S, Chen H, Tang H, Lu L, Jin W, Dong C.(2018) Deficiency in T follicular regulatory cells promotes autoimmunity. J Exp Med, 215(3):815-825.

24.    Zhang H, Zhang C, Tang H, Gao S, Sun F, Yang Y, Zhou W, Hu Y, Ke C, Wu Y, Ding Z, Guo L, Pei R, Chen X, Sun Sy M, Zhang B, Li C. (2018) CD2-associated Protein Contributes to Hepatitis C Virus Propagation and Steatosis by Disrupting Insulin Signaling. Hepatology. doi: 10.1002/hep.30073.

25.    Y Zhang, T Kim, JA Wroblewska, V Tesic, V Upadhyay, RR Weichselbaum, AV Tumanov, H Tang, X Guo, HD Tang & YX Fu (2018) Type 3 innate lymphoid cell-derived lymphotoxin prevents microbiota-dependent inflammation. Cell Mol Immunol, 15:697–709.

26.    S Hong, Z Zhang, H Liu, M Tian, X Zhu, Z Zhang, W Wang, X Zhou, F Zhang, Q Ge, B Zhu, H Tang*, Z Hua* and B Hou* (2108) B Cells Are the Dominant Antigen-Presenting Cells that Activate Naive CD4+ T Cells upon Immunization with a Virus-Derived Nanoparticle Antigen. Immunity, 49:695-708. (*co-correspondence)

27.    C Zhang, X Wang, S Li, T Twelkmeyer, W Wang, S Zhang, S Wang, J Chen, X Jin, Y Wu, X Chen, S Wang, J Niu, H Chen and H Tang (2019) NKG2A is a NK cell exhaustion checkpoint for HCV persistence. Nat Communs, 10: 1507.

28.    Yang S, Zhao Y, Yu J, Fan Z, Gong ST, Tang H*, Pan L*. (2019) Sugar Alcohols of Polyol Pathway Serve as Alarmins to Mediate Local-Systemic Innate Immune Communication in Drosophila. Cell Host & Microbe. 14;26(2):240-251.e8. (*co-correspondence)

29.    W Zhang,Y Xu, F Zhao, M Tarbe, S Zhou, W Wang, S Zhang, W Zhang, Q Xu, L Shi, F Yuan, X Lin,S Liu, J Sun, J Zhao, Y Yang, X Liang, J Zhong, G Long, C Qin, Q Leng, H Tang # (2020) The pre-existing cellular immunity to Japanese encephalitis virus heterotypically protects mice from Zika virus infection. Science Bulletin, 65(5):402-409. DOI: 10.1016/J.SCIB.2019.11.006

30.    Deng S, Sun Z, Qiao J, Liang Y, Liu L, Dong C, Shen A, Wang Y, Tang H*, Fu YX*, Peng H*. (2020) Targeting tumors with IL-21 reshapes the tumor microenvironment by proliferating PD-1^intTim-3^-CD8⁺ T cells. JCI Insight. Apr 9;5(7). pii: 132000. doi: 10.1172/jci.i9nsight.132000 (*co-correspondence).

31.    Zhang, C., Wang, F., Silvestre, J., Arenzana-Seisdedos F. & Tang H. (2020) Is aberrant CD8+ T cell activation by hypertension associated with cardiac injury in severe cases of COVID-19?. Cell Mol Immunol., https://doi.org/10.1038/s41423-020-0454-3

32.    X Lin, T Twelkmeyer, S Wang, R Xu, FS Wang, C Zhang, H Tang (2020) An Immunopathogenic Perspective of interleukin-1 Signaling. Cell Mol Immunol. May 28. doi: 10.1038/s41423-020-0475-y.

33.    L Huang, H Liu, K Zhang, Q Meng, L Hu, Y Zhang, Z Xiang, J Li, Y Yang, Y Chen, S Cui, H Tang, H Pei, Z Bu, C Weng (2020) Ubiquitin-Conjugating Enzyme 2S Enhances Viral Replication by Inhibiting Type I IFN Production through Recruiting USP15 to Deubiquitinate TBK1. Cell Rep., 32 (7), 108044. doi.org/10.1016/j.celrep.2020.108044

34.    X Lin, T Twelkmeyer, D Zhu, L Zhang, Y Zhao, C Zhang, Y Iwakura, G Meng, Z Hua, B Yan, W Liu, Z Luo, S Gong, H Chen, S Li, B Hou, H Tang (2021) Homeostatic regulation of T follicular helper and antibody response to particle antigens by IL-1Ra of medullary sinus macrophage origin. Proc Natl Acad Sci USA Apr 27;118(17):e2019798118.

35.    L Wang, J Lin, J Yu, K Yang, L Sun, H Tang* and L Pan*(2021) Downregulation of Perilipin1 by the Immune Deficiency Pathway Leads to Lipid Droplet Reconfiguration and Adaptation to Bacterial Infection in Drosophila. J Immunol, 207 (9) 2347-2358 (*co-correspondence)

36.    Zang JK#, Gu CJ#, Zhou BJ#, Zhang C#, Yang Y#, Xu SQ, Bai LL, Zhang R, Deng Q, Yuan ZH, Tang H, Q u D, Dimitri L*, Xie YH*, Huang Z* (2020) Immunization with the receptor-binding domain of SARS-CoV-2 elicits antibodies cross-neutralizing SARS-CoV-2 and SARS-CoV without antibody- dependent enhancement. Cell Discovery, 6:61.

37.    Zhang C#, Wang YF#, Zhu YF#, Liu CX#, Gu CJ#, Xu SQ#, Wang YL, Zhou Y, Wang YX, Han WY, Hong XY, Yang Y, Zhang XY, Wang YF, Xu C, Hong Q, Wang ST, Zhao QY, Q iao WH, Zang JK, Kong LL, Wang FF, Wang HK, Q u D, Dimitri L, Tang H, Deng Q*, Xie YH*, Cong Y*, Huang Z* (2021). Development and structural basis of a two-MAb cocktail for treating SARS-CoV-2 infections. Nature Comms, 12:264.