Ruhong Zhou, AAAS Fellow & APS Fellow, is currently Qiushi Chair Professor;  Dean, College of Life Sciences;  Dean, Shanghai Institute for Advanced Study;  and Director, Institute of Quantitative Biology, Zhejiang University, and an Adjunct Professor at Department of Chemistry, Columbia University. Before that, he was a Distinguished Research Staff Scientist, and Head of the Soft Matter Science Department at IBM Research.  His main research interests focus on Quantitative Biology; Machine Learning, Deep Learning in Biology; Biophysics; and Bio-Nano Interface (nanomedicine). Dr. Zhou has authored and co-authored more than 300 journal publications (including 32 in Science, Nature, Cell, Nature subjournals, and PNAS) with 24000+ total citations (Google H-index 81), filed 32 international patents and delivered 300+ invited talks at major conferences and universities worldwide. He is part of the IBM BlueGene team that won the 2009 National Medal on Technology (presented by President Obama). He has won the IBM Outstanding Technical Achievement Award (the highest technical award within IBM; 10 times), the IBM Outstanding Innovation Award (twice), and many IBM Research Division Awards. He also won the American Chemical Society DEC Award on Computational Chemistry. He was elected to AAAS Fellow (American Association of Advancement of Science) and APS Fellow (American Physical Society) in 2011. He received his PhD in Biophysical Chemistry from Columbia University, MS in Condensed Matter Physics and BS in Physics both from Zhejiang University.

Representative Publications:

1.   Qiang Zhu#, Hong Zhou#, Liming Wu, Jie Zhang, Yong Wang, Didi Geng, Zhiya Fan, Weijie Qin, Ruhong Zhou*, and Wen Yi*,  O-GlcNAcylation promotes pancreatic tumor growth by regulating malate dehydrogenase 1, Nature Chem. Biol., 18, 1087-1095, 2022

2.   Chengyu Shi#, Ying Wang#, Minjie Wu#, Yu Chen, Fangzhou Liu, Zheyuan Shen, Yiran Wang, Shaofang Xie, Yingying Shen, Lingjie Sang, Zhen Zhang, Zerui Gao, Luojia Yang, Lei Qu, Zuozhen Yang, Xinyu He, Yu Guo, Chenghao Pan, Jinxin Che, Huaiqiang Ju, Jian Liu, Zhijian Cai, Qingfeng Yan, Luyang Yu, Liangjing Wang, Xiaowu Dong, Pinglong Xu, Jianzhong Shao, Yang Liu, Xu Li*, Wenqi Wang*, Ruhong Zhou*, Tianhua Zhou*  and Aifu Lin*, Promoting anti-tumor immunity by targeting TMUB1, a modulator 2 of PD-L1 polyubiquitination and glycosylation, Nature Communications，13, 6951, 2022 

3.  Xiaolong Li*, Nishant Kumar Singh, Robert Ng, David R. Collins, Angela Zhang, Pedro A. Lamothe-Molina, Peter Shahinian, Shutong Xu, Kemin Tan, Alicja Piechocka-Trocha, Jonathan M. Urbach, Jeffrey K. Weber, Gaurav Gaiha, Overbeck Christian Takou Mbah, Tien Huynh, Sophia Cheever, James Chen, Michael Birnbaum, Ruhong Zhou, Bruce D. Walker*, and Jia-huai Wang*, Molecular basis of differential HLA class I-restricted T cell 2 recognition of a highly networked viral peptide，Nature Communications,in press, 2022

4.  Nannan Shen#, Zaixing Yang#, Shengtang Liu#, Xing Dai, Chengliang Xiao, Kathryn Taylor-Pashow, Dien Li, Chuang Yang, Jie Li, Yugang Zhang, Mingxing Zhang, Ruhong Zhou*, Zhifang Chai, Shuao Wang*,99TcO4−removal from legacy defense nuclear waste by an alkaline-stable 2D cationic metal organic framework, Nature Communications,11, 5571, 2020

5.   David R Bell, Jeffrey K Weber, Wang Yin, Tien Huynh, Wei Duan*, Ruhong Zhou*, In silico design and validation of high-affinity RNA aptamers targeting epithelial cellular adhesion molecule dimers, Proc. Natl. Acad. Sci., 117, 8486–8493,  2020

6.      Rizwan Ahmed, Zahra Omidian, Adebola Giwa, Benjamin Cornwell, Neha Majety, David R. Bell, Sangyun Lee, Hao Zhang, Aaron Michels, Stephen Desiderio, Scheherazade Sadegh-Nasseri, Hamid Rabb, Mario Suva, Simon Gritsch, Patrick Cahan, R. H. Zhou*, Chunfa Jie, Thomas Donner and Abdel R. Hamad*, Analysis of antigen-receptor sequences of a unique lymphocyte reveals a T cell-neoantigen encoded in a public BCR of T1D patients, Cell, 177, 1583–1599,  2019

7.      Binquan Luan*, R. H. Zhou, Spontaneous ssDNA stretching on graphene and hexagonal boron nitride in plane heterostructures, Nature Communications. 10, 4610, 2019

8.      Xiaomei Wang, Xing Dai, Cen Shi, Jianmei Wan, Mark A. Silver, Linjuan Zhang, Lanhua Chen, Xuan Yi, Bizheng Chen, Duo Zhang, Kai Yang, Juan Diwu*, Jianqiang Wang, Yujie Xu, R. H. Zhou*, Zhifang Chai, Shuao Wang*, A 3, 2-Hydroxypyridinone-based Decorporation Agent that Removes Uranium from Bones In Vivo, Nature Communications. 10, 2570, 2019

9.      Diego Chowell, Luc GT Morris, Claud M Grigg, Jeffrey K Weber, Robert M Samstein, Vladimir Makarov, Fengshen Kuo, Sviatoslav M Kendall, David Requena, Nadeem Riaz, Benjamin Greenbaum, James Carroll, Edward Garon, David M Hyman, Ahmet Zehir, David Solit, Michael Berger, R. H. Zhou, Naiyer A Rizvi, Timothy A Chan, Patient HLA class I genotype influences cancer response to checkpoint blockade immunotherapy, Science, 359, 582-587,  2018

10.      Ge Fang, Weifeng Li, Xiaomei Shen, Jose Manuel Perez-Aguilar, Yu Chong, Xingfa Gao, Zhifang Chai, Chunying Chen, Cuicui Ge*, and R. H. Zhou*, Differential Pd-Nanocrystal Facets Demonstrate Distinct Antibacterial Activity against Gram-positive and Gram-negative Bacteria, Nature Communications, 9, 129, 2018

11.      Yu Chong, Xing Dai, Ge Fang, Renfei Wu, Lin Zhao, Xiaochuan Ma, Xin Tian, Sangyun Lee, Chao Zhang, Chunying Chen, Zhifang Chai, Cuicui Ge, and R. H. Zhou, Palladium Concave Nanocrystals with High-index Facets Accelerate Ascorbate Oxidation in Cancer Treatment, Nature Communications, 9, 4861, 2018

12.      Alok V. Joglekar, Zhe Liu, Jeffrey K. Weber, Yong Ouyang, John D. Jeppson, Won Jun Noh, Pedro A. Lamothe-Molina, Huabiao Chen, Seung-gu Kang, Michael T. Bethune, R. H. Zhou*, Bruce D. Walker, David Baltimore*, HIV-specific T cell receptors from patients with differential immunologic control are functionally indistinguishable, Proc. Natl. Acad. Sci., 115, 1877-1882, 2018

13.     Binquan Luan, Ruhong Zhou*, Single-File Protein Translocations through Graphene–MoS2 Heterostructure Nanopores, J. Phys. Chem. Lett. 9, 3409–3415, 2018

14.    Nana Luo, Jeffrey K. Weber, Shuang Wang, Binquan Luan, Hua Yue, Xiaobo Xi, Jing Du, Zaixing Yang, Wei Wei, R. H. Zhou*, Guanghui Ma*, PEGylated Graphene Oxide Elicits Strong Immunological Responses Despite Surface Passivation, Nature Communications, 8, 14537, 2017

15.    T. Zheng, Z. X. Yang, D. Gui, Z. Liu, X. Wang, X. Dai, S. Liu, L. Zhang, Y. Gao, L. Chen, D. Sheng, Y. Wang, J. Diwu, J. Wang, R. H. Zhou*, Z. F. Chai, T. E. Albrecht-Schmitt, and S. Wang*, Overcoming the crystallization and designability issues in the ultrastable zirconium phosphonate framework system, Nature Communications 8, 15369, 2017

16.    Y. Li, Z. Yang, Y. Wang, Z. Bai, T. Zheng, X. Dai, S. Liu, D. Gui, W. Liu, M. Chen, L. Chen, J. Diwu, L. Zhu, R. H. Zhou*, Z. Chai, T. E. Albrecht-Schmitt, and S. Wang*, A Robust Mesoporous Cationic Thorium Organic Framework that Rapidly Traps Large Anionic Persistent Organic Pollutants, Nature Communications, 8, 1354, 2017

17.    Zhonghe Xu, Yang Sun, Jeffrey K. Weber, Yi Cao, Wei Wang, Daniel Jasinski, Peixuan Guo, R. H. Zhou, and Jingyuan Li, Directional mechanical stability of Bacteriophage ϕ29 motor’s 3WJ-pRNA: extraordinary robustness along portal axis, Science Advances, 3, e1601684, 2017

18.    Michael C. Baxa, Wookyung Yu, Aashish N. Adhikari, Liang Ge, Zhen Xia, R. H. Zhou*, Karl F. Freed, Tobin R. Sosnick*, Even with non-native interactions, the updated folding transition states of the homologs Protein G & L are extensive and similar, Proc. Natl. Acad. Sci. 112, 8302-8307, 2015

19.    Guillaume Stirnemann, Seung-Gu Kang, R. H. Zhou, and B. J. Berne, How Force Unfolding Differs from Chemical Denaturation, Proc. Natl. Acad. Sci. 111, 3413-3418, 2014

20.    Y. Tu, M. Lv, P. Xiu, T. Huynh, M. Zhang, M. Castelli, Z. R. Liu, Q. Huang, C. H. Fan, H. P. Fang, and R. H. Zhou, Destructive Extraction of Phospholipids from E. Coli Membrane by a Graphene Nanosheet, Nature Nanotech. 8, 594-601, 2013

21.    B. Dai, S. G. Kang, T. Huynh, H. Z. Lei, M. Castelli, J. Hu, Y. Zhang and R. H. Zhou, Salts Drive Controllable Multi-Layered Upright Assembly of Amyloid-like Peptides at Mica/Water Interface, Proc. Natl. Acad. Sci. 110, 8543-8548, 2013

22.    L. Cong, R. H. Zhou, Y. C. Kuo, M. Cunniff, and F. Zhang, Comprehensive Interrogation of Natural TALE DNA Binding Modules and Transcriptional Repressor Domains, Nature Commun. 3, 968, 2012

 23.    S. G. Kang, G. Q. Zhou, P. Yang, Y. Liu, B. Y. Sun, T. Huynh, H. Meng, L. Zhao, G. M. Xing, C. Y. Chen, Y. L. Zhao, R. H. Zhou, Molecular Mechanism of Pancreatic Tumor Metastases Inhibition by Metallofullerenol Gd@C82(OH)22: Implication for de novo Design of Nanomedicine, Proc. Natl. Acad. Sci., 109, 15431-15436, 2012 (featured article)

24.    P. Das, J. A. King, and R. H. Zhou, Aggregation of D-Crystallin Associated with Human Cataracts via Domain Swapping at the C-terminal -strands, Proc. Natl. Acad. Sci. 108, 10514-10519, 2011 (featured article)

25.    C. Ge, J. F. Du, L. Zhao, L. Wang, Y. Liu, D. H. Li, Y. Yang, R. H. Zhou, Y. L. Zhao, Z. F. Chai, C. Y. Chen, Binding of human serum proteins on single-wall carbon nanotubes reduces cytotoxicity, Proc. Natl. Acad. Sci, 108, 16968-16973, 2011 (featured article)

26.    Y. Tu, P. Xiu, R. Wan, J. Hu, R. H. Zhou and H. Fang, Water-mediated signal multiplication with Y-shaped carbon nanotubes, Proc. Natl. Acad. Sci. 106, 18120-18124, 2009

27.    L. Hua, R. H. Zhou, D. Thirumalai, B. J. Berne, Urea denaturation by stronger dispersion interactions with proteins than water implies a 2-stage unfolding, Proc. Natl. Acad. Sci., 105, 16928-16933, 2008 (featured article)

28.    J. Li, X. Gong, H. Lu, D. Li, H. Fang and R. H. Zhou, Electrostatic Gating of a Nanometer Water Channel, Proc. Natl. Acad. Sci., 104, 3687-3692, 2007

29.    R. H. Zhou, M. Eleftheriou, A. Royyuru, B. J. Berne, Destruction of long-range interactions by a single mutation in lysozyme, Proc. Natl. Acad. Sci., 104, 5824-5829, 2007

30.    P. Liu, X. Huang, R. H. Zhou and B. J. Berne, Observation of a dewetting transition in the collapse of melittin tetramer, Nature, 437, 159-162, 2005

31.    R. H. Zhou, X. Huang, C. Margulius and B. J. Berne, Hydrophobic Collapse in Multi-domain Protein Folding, Science, 305, 1605-1609, 2004

32.    R. H. Zhou, Trp-cage: Folding Free Energy Landscape in Explicit Water, Proc. Natl. Acad. Sci., 100, 13280-13285, 2003

33.    R. H. Zhou and B. J. Berne, Can a continuum solvent model reproduce the free energy landscape of a beta-hairpin folding in water?, Proc. Natl. Acad. Sci. 99, 12777-12782, 2002

34.    R. H. Zhou, B. J. Berne and R. Germain, Free energy landscape of a beta-hairpin folding in explicit water, Proc. Natl. Acad. Sci. 98, 14931-14936, 2001