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Wang, Ben Ph.D.
Associate Professor | Doctoral supervisor | Dean Assistant
二维码
2021-09-11 | 9753
  • 0571-86971683
  • Room 332, North Block of the the Central Building Huajiachi Campus, Zhejiang University
    • · Chemical Biology
    • · Bioinorganic Chemistry
    • · Medical Technology
    • · Translational Medicine

Biography

Ben Wang , Ph.D.


Associate Professor of Macromolecular Chemistry & Physics / Biochemistry & Molecular Biology / Oncology
Institute of Translational Medicine, School of Medicine, Zhejiang University
Cancer Institute, The Second Affiliated Hospital of Zhejiang University School of Medicine


Address: Hua-Jia-Chi Campus, 268 Kai-Xuan Road, Hangzhou, 310029 China


Education


09/2006 – 06/2011 Ph.D. in Chemistry & Biomedical Engineering, Zhejiang University & Harvard University (Joint PhD Program)

                                                               Supervisor: Prof. Ruikang Tang & Prof. Ali Khademhosseini
09/2004 – 06/2006 M.S. in Biology, Zhejiang University, China (Graduated with Honor)
                                                               Supervisor: Prof. Chengxin Fu
09/2000 – 06/2004 B.S. in Chemical Engineering, Qufu Normal University, China (Graduated with Honor)
                            

Professional Appointments


05/2017 – now          Dean Assistant, Institute of Translational Medicine, Zhejiang University
07/2013 – now          Associate Professor & Distinguished Young Scholar, Institute of Translational Medicine, Zhejiang University
07/2011 – 07/2013    Post-doctoral Research Fellow, Zhejiang University, Supervisor: Prof. Xiaoxiang Zheng
01/2010 – 01/2011    Research Assistant in the Wyss Institute for Biologically Inspired Engineering, Harvard University

01/2009 – 01/2010    Research Assistant in the Division of Health Sciences and Technology (HST), Harvard-MIT

Courses

College Biology

Scientific Writing Guidance for Postgraduate



Research

Area of Research

The Wang laboratory uses an interdisciplinary approach that integrates material science, biology, chemistry and engineering to solve problems in human health. It is emphasized that using Nature's design principles to develop bio-inspired materials and devices, and ultimately, transform medicine. From the physicochemical perspective, they are focused on understanding the molecular mechanisms involved in the interfaces of cell-cell, cell-materials, and develop the tools for cancer diagnosis and personalized medicine.

1. Cellular surface engineering

Cellular surface engineering here as a avenue of research covers two points, Firstly, it is with the purpose of exploring the molecular structure of cells from a biological perspective and secondly it aims at discovering the properties of materials from the scope of material science, such as surface topography and structure of extracellular matrix (ECM), cell size and shape, and so on.

2. Diagnostic macro/micro-devices based on cellular interface

Cell rolling and migration is an important physiological (such as tissue repair) and pathological process (such as cancer metastasis) that is used to recruit specific cells in the bloodstream to a target tissue. Learn from the similar process, we aim to develop microfluidics/paper-based technologies to sort cells (for more broad vision, exosome or bio-macromolecules such as DNA/RNA/proteins included) for cancer diagnostic and therapeutic applications.

3. Therapeutic micro/nano-tools based on cellular interface

Long systemic circulation lifetime is vital for drug delivery because long-circulating vehicles can more effectively localize in the disease sites, such as tumors and cardiovascular lesions. Erythrocytes, or red blood cells, are Nature's long-circulating delivery vehicles. We are interested in exploring and demonstrating the mechanism responsible for its roles. It will inspire the design and engineering of man-made delivery systems for cancer treatment in the future.

Focus

We focus on the biologically interficial engineering for translationla medicine, especially to study the interfaces of cell-cell, cell-materials, and develop the tools for cancer diagnostics and personalized therapeutics.

Technique Used

Biochemical and molecular biological technique, cell culture, chemical synthesis and characterization, electron microscopy, microfluidics, mouse (or primate) models.

Translational medicine potential
Early cancer diagnosis tools and personalized treatment methods; cell engineering and cell therapy.


Representative works

  1.  Ning Tang, Hanhui Li, Lihong Zhang, Xueyun Zhang, Yanni Chen, Hao Shou, Shuaishuai Feng, Xinhua Chen, Yan Luo, Ruikang Tang*, and Ben Wang*A macromolecular drug for cancer therapy via extracellular calcification. Angewandte Chemie International Edition, 2021, 60(12), 6509-6517. (Cover Picture)

  2.  Jicheng Wu#, Yanni Chen#, Jinxia Xin, Jiale Qin, Weizeng Zheng, Shuaishuai Feng, Chongran Sun, Mei Tian, Zhimin Lu, Ben Wang*Bioinspired tumor calcification enables early detection and elimination of lung cancer. Advanced Functional Materials, 2021, 31(27), 2101284.

  3. Ling Zhang, Guowu Liu, Kaiqi Lv, Jinxia Xin, Yingchao Wang, Jing Zhao, Wangxing Hu, Changchen Xiao, Keyang Zhu, Lianlian Zhu, Jinliang Nan, Ye Feng, Huaying Zhu, Wei Chen, Wei Zhu, Jianyi Zhang, Jian’an Wang, Ben Wang*, and Xinyang Hu*. Surface-anchored nanogel coating endows stem cells with stress resistance and reparative potency via turning down the cytokine-receptor binding pathways. Advanced Science, 2021, 8(3), 2003348.

  4. Yueqi Zhao, Mingjie Fan, Yanni Chen, Zhaoming Liu, Changyu Shao, Biao Jin, Xiaoyu Wang, Lanlan Hui, Shuaifei Wang, Zhaoping Liao, Daishun Ling, Ruikang Tang*, Ben Wang*Surface-anchored framework for generating RhD-epitope stealth red blood cells. Science Advances, 2020, 6(12): eaaw9679.

  5. Chuanjiang He, Tingting Ye, Wenqi Teng, Zhi Fang, Wei-Shuyi Ruan, Guowu Liu, Hui Chen, Jizeng Sun, Lanlan Hui, Feng Sheng, Dingyi Pan, Chunming Yang, Yi Zheng, Meng-Bo Luo, Ke Yao, and Ben Wang*Bioinspired shear flow-driven layer-by-layer in situ self-assembly. ACS Nano, 2019, 13(2), 1910–1922.

  6. Qingchang Tian, Chuanjiang He, Guowu Liu, Yueqi Zhao, Lanlan Hui, Ying Mu, Ruikang Tang, Yan Luo, Shu Zheng, and Ben Wang*Nanoparticle counting by microscopic digital detection: Selective quantitative analysis of exosomes via surface-anchored nucleic acid amplification. Analytical Chemistry, 2018, 90(11), 6556–6562.

  7. Ben Wang#, Guangchuan Wang#, Binjie Zhao, Jiajun Chen, Xueyun Zhang, and Ruikang Tang*. Antigenically shielded universal red blood cells by polydopamine-based cell surface engineering. Chemical Science, 2014, 5(9), 3463-3468.

  8. Ben Wang, Peng Liu, Wenge Jiang, Haihua Pan, Xurong Xu and Ruikang Tang*. Yeast cells with an artificial mineral shell: Protection and modification of living cells by biomimetic mineralizationAngewandte Chemie International Edition, 2008, 47 (19), 3560-3564.



Publications

Book Chapters:

  1. Wang B*, Cell Surface Engineering: Fabrication of Functional Nanoshells (Functional Multilayered Polyelectrolyte Assemblies on Biological Cells). Fakhrullin R, Choi I and Lvov Y (Ed.). The Royal Society of Chemistry (UK), 2014.

Peer Reviewed Articles:

2021

1.     Tang N, Li H, Zhang L, Zhang X, Chen Y, Shou H, Feng S, Chen X, Luo Y, Tang R* and Wang B*A macromolecular drug for cancer therapy via extracellular calcification. Angew. Chem. Int. Ed., 2021, 60(12), 6509-6517. (Front Cover Feature)

2.     Wu J#, Chen Y#, Xin J, Qin J, Zheng W, Feng S, Sun C, Tian M, Lu Z, Wang B*Bioinspired tumor calcification enables early detection and elimination of lung cancer. Adv. Funct. Mater., 2021, 31(27), 2101284.

3.     Zhang L#, Liu G#, Lv K#, Xin J, Wang Y, Zhao J, Hu W, Xiao C, Zhu K, Zhu L, Nan J, Feng Y, Zhu H, Chen W, Zhu W, Zhang J, Wang J, Wang B*, Hu X*. Surface-Anchored Nanogel Coating Endows Stem Cells with Stress Resistance and Reparative Potency via Turning Down the Cytokine-Receptor Binding Pathways. Adv. Sci., 2021, 8(3), 2003348.

4.     Shou H, Wu J, Tang N, Wang B*Calcification-Based Cancer Diagnosis and Therapy. ChemMedChem, 2021, 10.1002/cmdc.202100339.

5.     Lin X, Wu X, Chen X, Wang B*, Xu W*. Intellective and stimuli-responsive drug delivery systems in eyes. Int. J. Pharmaceut., 2021, 602, 120591.

2020

6.     Zhao Y#, Fan M#, Chen Y, Liu Z, Shao C, Jin B, Wang X, Hui L, Wang S, Liao Z, Ling D, Tang R*, Wang B*Surface-anchored framework for generating RhD-epitope stealth red blood cellsSci. Adv., 2020, 6 (12): eaaw9679.

·        Highlighted by Chemistry World (RSC).

7.     Wu J#, Hu S#, Zhang L, Xin J, Sun C, Wang L*, Ding K*, Wang B*Tumor circulome in the liquid biopsies for cancer diagnosis and prognosisTheranostics, 2020, 10 (10): 4544-4556. (Front Inside Cover)

8.     Fang Z#, Chen H#, Teng W#, Qiu P, Yu X, Luo C, Zhu Y, You Y, Fu Q, Ji J, Wang B*, Yao K*. Systemic transplantation of eyelid adipose-derived stem cells for antifibrotic treatmentAdv. Therap., 2020, 3, 1900191.

9.     Yin J, Zou Z, Hu Z, Zhang S, Zhang F, Wang B, Lv S, Mu Y. A "sample-in-multiplex-digital-answer-out" chip for fast detection of pathogens. Lab chip, 2020, 20 (5), 979-986.

10.  Zhuang J, Yin J, Lv S, Wang B, Mu Y. Advanced “lab-on-a-chip” to detect viruses – Current challenges and future perspectives. Biosens. Bioelectron., 2020, 163, 112291.

11.  Yin J, Zou Z, Yin F, Liang H, Hu Z, Fang W, Lv S, Zhang T, Wang B, Mu Y. A Self-Priming Digital Polymerase Chain Reaction Chip for Multiplex Genetic Analysis. ACS Nano, 2020, 14, 8, 10385–10393.

12.  Yin J, Hu J, Yin F, Sun J, Wang B, Mu Y. A fast nucleic acid extraction system for point-of-care and integration of digital PCR. Analyst, 144 (23), 7032-7040.

13.  Lv K, Li Q, Zhang L, Wang Y, Zhong Z, Zhao J, Lin X, Wang J, Zhu K, Xiao C, Ke C, Zhong S, Wu X, Chen J, Yu H, Zhu W, Li X, Wang B, Tang R, Wang J, Huang J, Hu X. Incorporation of small extracellular vesicles in sodium alginate hydrogel as a novel therapeutic strategy for myocardial infarction. Theranostics, 2019, 9 (24), 7403-7416.

2019

14.  Su Y#, Tian Q#, Pan D#, Hui L, Chen Y, Zhang Q, Tian W, Yu J, Hu S, Gao Y, Qian D, Xie T, Wang B*. Antibody-functional microsphere-integrated filter chip with inertial microflow for size–immune-capturing and digital detection of circulating tumor cellsACS Appl. Mater. Interfaces, 2019, 11, 33, 29569-29578.

15.  He C#, Ye T#, Teng W#, Fang Z, Ruan W, Liu G, Chen H, Sun J, Hui L, Sheng F, Pan D, Yang C, Zheng Y, Luo M, Yao K, Wang B*Bioinspired shear flow-driven layer-by-layer in situ self-assembly. ACS Nano, 2019, 13 (2), 1910–1922. 

2018

16.  Tian Q, He C, Liu G, Zhao Y, Hui L, Mu Y, Tang R, Luo Y, Zheng S, Wang B*Nanoparticle Counting by Microscopic Digital Detection: Selective Quantitative Analysis of Exosomes via Surface-Anchored Nucleic Acid Amplification. Anal. Chem., 2018, 90 (11), 6556–6562.

17.  Hui L, Su Y, Ye T, Liu Z, Tian Q, He C, Zhao Y, Chen P, Wang X, Han W, Luo Y, Wang B*Self-Sterilizing and Regeneratable Microchip for the Precise Capture and Recovery of Viable Circulating Tumor Cells from Patients with Cancer. ACS Appl. Mater. Interfaces, 2018, 10 (1), 207–218.

18.   He C, Zheng S*, Luo Y*, Wang B*Exosome Theranostics: Biology and Translational Medicine. Theranostics, 2018, 8 (1), 237-255.

2017

     19.  Xiao Y, Wang X, Wang B, Liu X, Xu X, Tang R*. Long-term Effect of Biomineralized Insulin Nanoparticles on Type 2 Diabetes Treatment. Theranostics, 2017, 7 (17), 4301-4312.

      20.  Liu W, Yin B, Wang X, Yu P, Duan X, Liu C, Wang B, Tao ZCirculating tumor cells in prostate cancer: Precision diagnosis and therapy. Oncol. Lett., 2017, 14 (2), 1223-1232.

2016

21.   Zhao R, Wang B, Yang X, Xiao Y, Wang X, Shao C, Tang R*. A drug-free tumor therapy strategy: Cancer-cell-targeting calcification. Angew. Chem. Int. Ed., 2016, 55 (17), 5225-5229. (VIP)

2015

22.  Rao Y, Chen W, Liang X, Huang Y, Miao J, Liu L, Lou Y, Zhang X, Wang B, Tang R, Chen Z, Lu X*. EpirubicinLoaded Superparamagnetic Iron-Oxide Nanoparticles for Transdermal Delivery: Cancer Therapy by Circumventing the Skin Barrier. Small, 2015, 11 (2), 239-247.

2014

23.  Xiao Y, Zhou H, Xuan N, Cheng M, Luo Y, Wang B*, Tang R. Effective and selective cell retention and recovery from whole blood by electroactive thin films. ACS Appl. Mater. Interfaces, 2014, 6 (23), 20804–20811.

24.  Wang B*, Zhou H, Luo Y, Tang R, Zheng S. Biological interfacial engineering for metastatic cancer diagnosis and interventionCurr. Med. Chem., 2014, 21 (22), 2510-2521.

25.  Wang B#, Wang G#, Zhao B, Chen J, Zhang X, Tang R*. Antigenically shielded universal red blood cells by polydopamine-based cell surface engineeringChem. Sci., 2014, 5 (9), 3463-3468.

·        Highlighted by Chemistry World (RSC).

26.  Wang B*, Liu P, Liu Z, Pan H, Xu X, Tang R*. Biomimetic construction of cellular shell by adjusting the interfacial energy. Biotechnol. Bioeng., 2014, 111 (2), 386-395.

27.  Liu Z, Xiao Y, Chen W, Wang Y, Wang B, Wang G, Xu X, Tang R*. Calcium phosphate nanoparticles primarily induce cell necrosis through lysosomal rupture: the origination of material cytotoxicity. J. Mater. Chem. B., 2014, 2 (22), 3480-3489.

2013

28.  Wang B, Tang R*. Biomineralization: one promising bridge between inorganic chemistry and biomedicine. Prog. Chem., 2013, 25 (4), 633-641.

29.  Liu P, Chen Y, Wang G, Wang B, Xu X and Tang R*. Cell death induced by in situ mineralized calcium phosphate in growth microenvironment. Chinese J. Inorg. Chem., 2013, 29 (1), 89-94.

2012

30.  Coutinho D, Sant S, Shakiba M, Wang B, Gomes M, Neves N, Reis R, Khademhosseini A*. Microfabricated photocrosslinkable polyelectrolyte-complex of chitosan and methacrylated gellan gum. J. Mater. Chem., 2012, 22 (33), 17262-17271.

2011

31.  Xu X*, Wang B, Tang R. Hybrid materials that integrate living cells: Improved eco-adaptation and environmental applications. ChemSusChem, 2011, 4 (10), 1439-1446.

32.  Mahmoudi M*, Sant S, Wang B, Laurent S and Sen T. Superparamagnetic iron oxide nanoparticles (SPIONs): development, surface modification and applications in chemotherapyAdv. Drug Deliver. Rev., 2011, 63 (1-2), 24-46.

·        Top 25 hottest papers in Elsevier

33.  He J, Du Y, Guo Y, Hancock MJ, Wang B, Shin H, Wu J, Li D, Khademhosseini A*. Microfluidic-based synthesis of composite materials with cross-gradient for screening cell-biomaterial interactions. Biotechnol. Bioeng., 2011, 108 (1), 175-185.

34.  Wu J, Wheeldon I, Guo Y, Lu T, Du Y, Wang B, He J, Hu Y, Khademhosseini A*. A sandwiched microarray platform for benchtop cell-based high throughput screening. Biomaterials, 2011, 32 (3), 841-848.

35.  Xiao W, He J, Nichol JW, Wang L, Huston CB, Wang B, Du Y, Fan H, Khademhosseini A*. Synthesis and characterization of photocrosslinkable gelatin and silk fibroin interpenetrating network hydrogel. Acta Biomater., 2011, 7 (6), 2384-2393.

2010

36.  Wang B#, Liu P# and Tang R*. Cellular shellization: Surface engineering gives cells an exterior. BioEssays, 2010, 32 (8), 698-708.

37.  Wang B, Liu P, Tang Y, Pan H, Xu X and Tang R*. Guarding embryo development of zebrafish by shell engineering: a strategy to shield life from ozone depletionPLoS One, 2010, 5 (4), e9963.

38.  Du Y, Hancock MJ, He J, Villa-Uribe JL, Wang B, Cropek DM, Khademhosseini A*. Convection-driven generation of long-range material gradients. Biomaterials, 2010, 31 (9), 2686-2694.

2009

39.  Jiang W, Chu X, Wang B, Pan H, Xu X and Tang R*. Biomimetically triggered inorganic crystal transformation by biomolecules: A new understanding of biomineralization. J. Phys. Chem. B, 2009, 113 (31), 10838-10844.

2008

40.  Tao J, Pan H, Wang J, Wu J, Wang B, Xu X and Tang R*. Evolution of amorphous calcium phosphate to hydroxyapatite probed by gold nanoparticles. J. Phys. Chem. C, 2008, 112 (38), 14929-14933.

41.  Wang B, Liu P, Jiang W, Pan H, Xu X and Tang R*. Yeast cells with an artificial mineral shell: Protection and modification of living cells by biomimetic mineralizationAngew. Chem. Int. Ed., 2008, 47 (19), 3560-3564.

·        Selected by Faculty of 1000 Biology (F1000 Factor 9.0)

·        Highlighted by Nature China, Reuters, Chemical & Engineering News (ACS), Chemical Science (RSC), Physorg and New Scientist, etc.

Patents

1.     Wang B, Xiao Y, Tang R. A microfluidics chip for cell sorting and harvest and application thereof. Zhejiang University. Patent No. 2014 1 0467913.4. Time of Authorization: Apr 17, 2017.

2.     Wang B, He C, Ye T. A thin cell sheet and the preparation method. Zhejiang University. Patent No. 201710121360.0. Time of Authorization: Dec 19, 2019.

3.     Wang B, Hui L, Luo Y. A cell sorting and enrichment method for circulating tumor cells relied on the cocktail of antibodies. Zhejiang University. Patent No. ZL 2017 1 0592348.8. Time of Authorization: Jan 8, 2020.

4.     Wang B, Hui L, Su Y. A self-sterilizing and regeneratable microchip for the precise capture and recovery of cells and the cycling method. Zhejiang University. Patent No. ZL 2017 1 0592843.9. Time of Authorization: Aug 16, 2019.

5.     Wang B, Zhao Y, Fan M, Tang R. A hydrogel-based method for single cell encapsulation, the related products and the applications in preparation of universal red blood cells. Zhejiang University. Patent No. ZL 2017 1 0908231.6. Time of Authorization: Feb 7, 2020.

6.     Wang B, Liu G. A hydrogel-based method for single cell encapsulation to enhance the resistance of stem cells in cell therapy. Zhejiang University. Patent No. ZL 2017 1 0910443.8. Time of Authorization: March 5, 2021.

7.     Wang B, Su Y. A microfilter chip integrated with functional microbeads for capture of circulating tumor cells and application thereof. Zhejiang University. Patent No. ZL 2017 1 1085698.1. Time of Authorization: Aug 16, 2019.

8.     Wang B, Ye T, He C. A thin films prepared by layer-by-layer assembly and thereof. Zhejiang University. Patent Application No. 201711245227.2. Time of Authorization: Aug 18, 2020.


Funding Information

2021 – 2023 Key Project from NSF of Zhejiang Province Z21H160013 (¥ 300,000, Principal Investigator)

Targeted calcification for the diagnosis and therapy of folate receptor high-expressing tumors

2019–2021 Open Research Project of Military Logistics (¥ 500,000, Investigator)

2017 – 2018 Innovation and Cultivation Project of the Science and Technology Commission of the Military Commission on Biological and Cross-Cutting Science and Technology (¥ 500,000, Principal Investigator)

2016 – 2020 National Key R&D Program “Research and Development of Biological and Medical Materials for Tissue and Organ Replacement” 2016YFC1100800 (¥ 500,000, Investigator, 3/8)

The dermal substitute based on polyglycolide and its copolymers fiber composites induces tissue regeneration in situ 

2016 – 2019 Distinguished Young Scientist Award from NSF of Zhejiang Province LR16H180001 (¥ 300,000, Principal Investigator)

Cardiac regeneration based on cell surface engineering: Toward heart stem cell therapeutics

2016 – 2019 NSFC Grant 81570168 (¥ 600,000, Principal Investigator)

Universal red cells constructed by cell surface engineering for translational applications of blood transfusion

2015 – 2017 NSFC Young Investigator Grant 81401541 (¥ 230,000, Principal Investigator)

The cell sorting system based on cell-materials interfacial engineering

2015 – 2017 Major Project of Science and Technology Department of Zhejiang Province 2014C03048-2 (¥ 1,000,000, Investigator, 2/10)

CTC chip: The integrated system for cancer diagnostics, intervention and prognostics

2013 – 2014 The Special Support from China Postdoctoral Science Foundation (6th) 2013T60600 (¥ 150,000, Principal Investigator)

Universal red cells by a simple cell-superficial-engineering for blood transfusion

2012 – 2014 National Natural Science Fund of China 91127003 (Investigator, 2/9)

Self-assembly mechanism in biomineralization and bio-inspired hard tissue repair

2011 – 2013 The First Class General Financial Grant from the Chinese Postdoctoral Science Foundation (50th) 2011M500136 (¥ 50,000, Principal Investigator)

Preserving cell viability at positive temperatures

2008 – 2010 The Chinese Universities Scientific Fund awarded by the China Scholarship Council (CSC) 2008632016 (Awardee)


Honors and Awards

2020   Outstanding Faculty Member (Institute of Translational Medicine, ZJU)

2019   Young Excellent Abstract Awards (The XVII International Symposium on Blood Substitutes and Oxygen Therapeutics, Japan)

2019   Outstanding Faculty Member (Zhejiang University School of Medicine)

2018   Outstanding Faculty Member (Institute of Translational Medicine, ZJU)

2017   Excellent Postdoctoral Fellow (Department of Human Resources and Social Security of Zhejiang Province)

2017   Outstanding Faculty Member (Institute of Translational Medicine, ZJU)

2017   Excellent Moral Tutor for Postgraduate (Zhejiang University School of Medicine)

2016   Excellent Class Adviser (CKC Honor College, Zhejiang University)

2016   Outstanding Faculty Member (Institute of Translational Medicine, ZJU)

2015   Distinguished Young Scientist Award (NSF of Zhejiang Province)

2014   Significant Contribution Prize in Publication (Zhejiang University School of Medicine)

2014   Outstanding Faculty Member (Institute of Translational Medicine, ZJU)

2013   Distinguished Young Scholar (Zhejiang University)

2009   Leadership Scholarship (Committee of 100)

Lecture Presentations

1.     Calcification-based cancer diagnosis and therapy. 16th International Symposium on Biomineralization, Invited Speaker, 22-27 August 2021, Hangzhou, China.

2.     Chemical biology of cell surface and its translational medicine. 2021 West Lake International Conference on Ultrasound Medicine and International Society for Ultrasound Contrast, Invited Speaker, May 26-30, 2021, Hangzhou, China.

3.     Micro-nano technology at cell surface. Micro and Nano Technology and Medical Health Innovation Conference (2021) and the Fifth Micro and Nano Technology Application and Innovation Conference of the Chinese Society of Micro and Nano Technology, Invited Speaker, May 29-31, 2021, Shanghai, China.

4.     Chemical biology and translational medicine on cell surface. 2021 XIZI Joint Cardiovascular Conference, Invited Speaker, May 17-22, 2021, Hangzhou, China.

5.     Chemical biology of the cell surface and its transformational medicine. Zhejiang Hematology Congress 2020, Speaker, November 6-8, 2020, Hangzhou, China.

6.     Chemical biology of the cell surface and its transformational medicine. 2020 Conference of Zhejiang Medical Association of Ultrasonic Medicine, Speaker of Youth Forum, September 11-13, 2020, Hangzhou, China.

7.     Cell surface engineering and transformational medicine. The 13th Guangji Academic Joint Forum of Institute of Translational Medicine, Zhejiang University – The Second Affiliated Hospital of Zhejiang University School of Medicine, Speaker, October 29, 2019, Hangzhou, China.

8.     Liquid biopsy in oncology and obstetrics. The Third Qianjiang Forum and Multidisciplinary Interdisciplinary Symposium on the diagnosis and treatment of pregnancy complications, Speaker, September 21-22,2019, Hangzhou, China.

9.     Cell surface engineering and transformational medicine. The Annual Meeting of Branch of Restoration and Regeneration, Zhejiang Medical Association, November 29-31, Hangzhou, China.

10.  Cell surface engineering and translational medicine. 2019 Annual Conference on Biomaterials & International Conference on Advanced Biomaterials, Speaker, August 22-25, 2019, Dalian, China.

11.  Bioinspired shear flow-driven layer-by-layer in situ self-assembly. Xizi Cardiovascular Joint Conference, Speaker, May 10-12, 2019, Hangzhou, China.

12.  Cell surface engineering and single cell transformation medicine. Annual Stem Cell Conference, Speaker of Youth Forum, September 14-16, 2018, Jinan, China.

13.  Towards to single-cell translational medicine based on cell surface engineering. Keynote speaker and section chair in Hangzhou International Conference on Biomaterials, Bio-Design and Manufacturing in conjunction with H2020 BAMOS Project 2018 meeting, August 26-28, 2018, Hangzhou, China.

14.  Cell surface engineering and related translational medicine. Invited speaker in the 1st Glycoscience Youth Forum, May 26th – 27th, 2018, Suzhou, China.

15.  Single cell surface engineering and related translational medicine. Invited speaker in the XIZI Joint International Cardiovascular Conference (XIZI-JICC), May 11th – 13th, 2018, Hangzhou, China.

16.  Universal red cells constructed by cell surface engineering for translational applications of blood transfusion. Invited speaker in the National Conference on Microcirculation in 2017, November 24th – 26th, 2017, Beijing, China.

17.  Surface engineering of single cell and their translational medicine. Invited speaker in West-East Lake Autumn Forum on Biomedicine in 2017, October 17th-18th, 2017, Hangzhou, China.

18.  Biological interfacial engineering for oncology theranostics. The West Lake Chest Oncology Forum and the 10th Chest Oncology Forum of Zhejiang Province in 2017, June 30th-July 2nd, 2017 Huzhou, China.

19.  Cell surface engineering and single cell translational medicine. Oral speaker in the 13th National Conference on Biological Inorganic Chemistry, October 13th - 18th, 2016, Shanghai, China.

20.  Universal red cells constructed by cell surface engineering for translational applications of blood transfusion. Invited speaker in the International Conference on Hemorheology and Microcirculation in 2016, October 10th – 12th, 2016, Qiqihar, China.

21.  Cell surface engineering and single cell translational medicine. Invited speaker in Cancer Center of the First Affiliated Hospital of Zhejiang University, July 18th, 2016, Hangzhou, China.

22.  Cell surface engineering and single cell translational medicine. Invited speaker in ZJ College, April 21th, 2016, Hangzhou, China.

23.  Single cell encapsulation for tissue repair. Invited speaker in 137th Xi-Hu Forum of Translational medicine in Stem Cell, April 18th, 2016 Hangzhou, China.

24.  Single cell translational medicine. Invited speaker in CTC Forum, Oct 15th, 2015 Hangzhou, China.

25.  Single cell translational medicine. Section chair & keynote speaker (plenary lecture) in Biomarker Forum, Sep 17-18th, 2015 Shanghai, China.

26.  Cellular interfacial engineering for single cell modification and manipulation. Speaker in 121th Xi-Hu Forum of Translational Medicine in Oncology, Nov 5th, 2014 Hangzhou, China.

27.  Cellular interfacial engineering for single cell modification and manipulation. Invited speaker in Basic-Clinical Joint Forum, Oct 31th, 2014 Hangzhou, China.

28.  Cellular interfacial engineering for single cell modification and manipulation. Invited speaker in the 1st East Asian Forum on Biofunctional Materials and Regenerative Medicine, April 18-22, 2014 Hangzhou, China.

29.  Cellular interfacial engineering for translational medicine. Invited speaker in The Second Affiliated Hospital School of Medicine, Zhejiang University, May 7, 2014 Hangzhou, China.

30.  Biological interfacial engineering for translational medicine research. Faculty position searching seminar in School of Medicine, Zhejiang University, March 28, 2013 Hangzhou, China.

31.  Cell microenvironment-based tumor targeting strategy. The 11th National Conference on Biological Inorganic Chemistry, September 16-19, 2011 Baoding, China.

32.  Nanobiology: Vital problems of single-cell biomineralization. The 6th Zhejiang University doctoral Innovation Forum, November 26, 2008 Hangzhou, China.


Students Tutoring

Postdoc Fellows

Kaixin Zhang (2019 – 2021, Chemistry)

Qingchang Tian (2016 – 2018, Biochemistry and Molecular Biology | Faculty Member at Hangzhou Normal University, Received the Early Career Fund of National Natural Science Foundation of China in 2018)

Yun Xiao (2016 – 2018, Chemistry | Faculty Member at The Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Received the Early Career Fund of National Natural Science Foundation of China in 2021)

PhD Students

Yuanhao Chen (2021-2026, Biochemistry & Molecular Biology)

Xinliang Ming (2020-2023, Oncology)

Hao Shou (2019 – 2024, Biochemistry & Molecular Biology)

Jicheng Wu (2018 – 2022, Oncology)

Hanhui Li (2017 – 2022, Oncology)

Ning Tang (2016 – 2019, Oncology | Doctor at Hangzhou First Affiliated Hospital, Zhejiang University School of Medicine)

Mingjie Fan (2016 – 2019, Biochemistry & Molecular Biology | Study at Abroad)

Lanlan Hui (2015 – 2018, Biochemistry & Molecular Biology | Postdoc at College of Pharmacy, Shanghai Jiaotong University)

Yueqi Zhao (2015-2020, Chemistry, Joint PhD student | Faculty Member at The Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Received the Early Career Fund of National Natural Science Foundation of China in 2021)

Master Students

Yuqiao Huang (2020-2022, Oncology)

Haoran Wang (2019-2022, Biochemistry & Molecular Biology)

Jinxia Xin (2018 – 2021, Biochemistry & Molecular Biology | R & D of Star-up Company at Shanghai)

Yanni Chen (2017 – 2020, Oncology | PhD Candidate at Zhejiang University)

Chuanjiang He (2015 – 2018, Biochemistry & Molecular Biology | Study at Abroad)

Yi Su (2014 – 2017, Biochemistry & Molecular Biology | PhD Candidate at Westlake University)

Guowu Liu (2014 – 2017, Biophysics | R & D of Star-up Company at Shanghai)

Undergraduate Students

Haoran Wang (2015, Biology)

Hao Shou (2015, Polymer Materials and Engineering)

Jizeng Sun (2014, Chemistry)

Hanhui Li (2013, Chemistry)

Student Awards

Hao Shou (The National Second Prize of the 17th "Challenge Cup" Competition in 2021, Room Temperature Vaccines Wrapped in Polymer "Coat")

Jicheng Wu (2020 Excellent Graduate Student Award, 2019 Excellent Graduate Student Leader Award)

Lanlan Hui (2018 Excellent Graduate Student Scholarship)

Chuanjiang He (2017 National Graduate Student Scholarship)

Guowu Liu (2016 The Excellent Thesis on the 6th Sino-American Symposium on Clinical and Translational Medicine)

Admission & Employment

Ben Wang Ph.D.

Associate Professor

 

Contact Information

E-mail: benwang(a)zju.edu.cn

Tel: 0571-86971683

Fax: 0571-86971683

        Located in the picturesque city of Hangzhou, Zhejiang University (ZJU) is the most comprehensive leading university in China, with a long history, unique features and high reputations in education and research. Supported by resources from the University, Medical School, and six affiliated hospitals, ZJU has recently established a new institute committed to translational research, namely the Institute of Translational Medicine (ITM). The major goal of the ITM is, through multi-disciplinary and cross-functional collaborations, to bridge the gap between basic science and clinical practice for better translation of bench breakthrough to bedside therapy. Our laboratory is uniquely positioned at the ITM, which allows us to actively collaborate with outstanding biologists, clinicians, engineers and materials scientists to quickly translate our research findings and technologies to the clinic to benefit suffering patients. Our laboratory (wanglab.zju.edu.cn) is located at the North Block of the Central Building, Hua-Jia-Chi Campus of ZJU, which is equipped with many state-of-art core facilities dedicated for training and research. 

Postdoc Position

Position Requirements

1)    Doctor’s Degree on Chemistry (Macromolecular Chemistry & Physics / Organic Chemistry  / Inorganic Chemistry  / Analytical Chemistry / Physical Chemistry), Biology (Immunology / Biological Chemistry & Molecular Biology), Engineering (Materials Science and Engineering / Microelectronics / hydromechanics), or Basic and Clinic Medicine (Stem Cell & Regenerative Medicine / Oncology / Internal Medicine

2)    High passion and curiosity on science, innovative and independent thinking on research, and strong experimental design and problem-solving ability

3)    Easy-going with good communication skills, teamwork spirit with strong sense of responsibility.

Application Materials

1)    CV

2)    Other related materials to prove your ability and scientific research experience

3)    Three reference list and their contact information.

Remuneration Benefits

We will offer you a competitive compensation and benefits package, and an exciting atmosphere for career growth.

Ph.D. Program

Program 1

Macromolecular Chemistry & Physics

Major Number

070305

Degree Type

Doctor of Science

Research Interests

1)    The molecular engineering of cell surface

2)    The synthesis and self-assembly of macromolecular materials

3)    The surface modification and assembly of engineered materials 

Admission Approach

1)    Admitted from undergraduate level

2)    Admission test for Master 

Subject 1: English; Subject 2: Macromolecular Chemistry; Subject 3: Comprehensive examination

3)    Admitted from graduate student level

Program 2

Biochemistry and Molecular Biology▲

Major Number

071010

Degree Type

Doctor of Science

Research Interests

1)    Cell surface modification and functional adjustment

2)    The interaction between materials and cells

3)    Stem cells and regenerative medicine

Admission Approach

1)    Admitted from undergraduate level

2)    Admission test for Master

Subject 1: English; Subject 2: Molecular Biology (Second) / Cell Biology / Pathology and pathophysiology; Subject 3: Comprehensive examination

3)    Admitted from graduate student level

Program 3

Oncology 

Major Number

100214

Degree Type

Doctor of Medicine (PhD)

Research Interests

Cancer diagnostics and therapy based on circulating tumor cells (CTCs)

Admission Approach

1)    Admitted from undergraduate level

2)    Admission test for Master

Subject 1: English; Subject 2: Molecular Biology (Second) / Cell Biology / Pathology and pathophysiology; Subject 3: Comprehensive examination

3)    Admitted from graduate level

Program Duration

5 years for undergraduate level; 4 years for Master level; 3 years for students admitted from graduate level. 

Master Program

Program 1

Macromolecular Chemistry & Physics

Major Number

070305

Degree Type

Master of Science

Research Interests

1)    The molecular engineering of cell surface

2)    The synthesis and self-assembly of macromolecular materials

3)    The surface modification and assembly of engineered materials

Admission Approach

1)    Admitted from undergraduate level

2)    Admission test for undergraduate

Subject 1: 101 Politics; Subject 2: 201 English; Subject 3: 

Type 1: Subject 3: 302 Mathematics (Second); Subject 4: 837 Macromolecular Physics & Chemistry or 836 Fundamentals of Material Science / 838 The Principles of Chemical Engineering / 821 Organic Chemistry

Type 2: Subject 3: 726 Physical Chemistry (First, Structural Chemistry included); Subject 4: 821 Organic Chemistry 

Program 2

Biochemistry & Molecular Biology▲

Major Number

071010

Degree Type

Master of Science

Research Interests

1)    Cell surface modification and functional adjustment

2)    The interaction between materials and cells

3)    Stem cells and regenerative medicine

Admission Approach

1)    Admitted from undergraduate level

2)    Admission test for undergraduate

Subject 1: 101 Politics; Subject 2: 201 English; Subject 3: 

Type 1: Subject 3: 727 Cell Biology / Mathematics (agricultural); Subject 4: 830 Biochemistry & Molecular Biology (50% respectively)

Type 2: Subject 3: 731 Medical Biochemistry; Subject 4: 859 Physiology 

Program 3

Oncology ▲

Major Number

100214

Degree Type

Master of Medicine

Research Interests

Cancer diagnostics and therapy based on circulating tumor cells (CTCs)

Admission Approach

1)    Admitted from undergraduate level

2)    Admission test for undergraduate

Subject 1: 101 Politics; Subject 2: 201 English; Subject 3: Comprehensive ability of clinical medicine (Western Medicine)

Program Duration

3 years


Remark

Graduate and undergraduate students majored in material science and engineering, chemical engineering, microelectronics, physics, chemistry, pharmacy, medicine and biology are welcome. Please contact with Prof. Wang for details if you are interested.


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