Dr. Shiyin is dedicated to exploring the mechanisms by which cells adapt to external stress and how these changes impact disease development and therapy, particularly in cancer and other diseases. From 2010 to 2017, she pursued her Ph.D. and postdoctoral training at the National University of Singapore's Yong Loo Lin School of Medicine under the mentorship of Professor Shen Hanming, an expert in the field of autophagy. Her research focused on understanding the molecular mechanisms of macroautophagy in helping tumors adapt to hypoxic or nutrient-deprived environments, with potential clinical applications.

As the first or corresponding author, Dr. Shiyin has published several high-impact papers in top-tier journals such as Free Radical Bio Med (IF: 8.17, Q2, top) and Theranostics (2024, Q1, cover article). Her research also uncovered how breast cancer cells utilize lipid raft-autophagy regulation to resist unfavorable microenvironments and drug-induced damage, with findings published in Autophagy (IF: 16.142, Q1, top) and Mol Ther-Oncolytic (IF: 6.71, Q2). Furthermore, she was the first to report the molecular mechanisms by which artemisinin selectively induces tumor cell death, published in ACS Central Sci (2017, IF: 18.728, Q1, top).

Since joining Zhejiang University in 2017 as a Lecturer in the Department of Basic Medical Sciences, Dr. Shiyin has advanced to Associate Professor and worked within the teams of Professors Wang Qingqing, focusing on autophagy and tumor immunology. She has accumulated extensive research experience in super-resolution microscopy, tumor bioinformatics, and tumor immune signaling pathways. During her academic career, Dr. Shiyin has been the principal investigator for a National Natural Science Foundation of China (NSFC) Youth Program and General Program and has participated as a key member in three national-level research projects. She has published 15 articles, 8 as the first author, with a total impact factor of 78.23.

Key Research Contributions:

1. Systematically elucidated the molecular mechanisms of PRL-3 (phosphatase of regenerating liver-3) in promoting macroautophagy via the p36-MAPK signaling pathway, helping tumors adapt to hypoxic or nutrient-deprived stress, published in Free Radical Bio Med and Theranostics.

2. Identified how breast cancer cells regulate lipid raft-autophagy to resist adverse microenvironments and drug-induced damage, published in Autophagy and Mol Ther-Oncolytic.

3. Reported the molecular mechanisms of artemisinin-induced selective tumor cell death, published in ACS Central Sci.
   Additionally, Dr. Shiyin has contributed to collaborative research published in prestigious journals such as Cell Research, Molecular Cell, and Autophagy.