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唐龙华 博士
副教授 | 博士生导师
二维码
2023-02-06 | 35889
  • 浙江大学第三教学楼415-3
    • · 纳米光电子器件
    • · 光电超快测量技术
    • · 生物分子精准测量

个人简介

唐龙华  博士 /  副教授 / 博士生导师 


      2013年博士毕业于清华大学; 2013-2015,浙江大学光电科学与工程学院,特聘副研究员;2016至今,副教授,博士生导师。曾在美国伊利诺伊香槟分校、英国帝国理工学院访问交流。迄今在Science Advances、Nature Communications等国际知名术期刊发表SCI论文60余篇,论文总被引10000余次,单篇最高他引1000+次(google scholar)。作为项目负责人主持国家自然科学基金、浙江省自然科学基金、国家重点研发计划等各类科研项目10余项;曾于2013年荣获教育部自然科学一等奖(4/7),2015年荣获国家自然科学二等奖(5/5),2021年获得浙江省杰出青年基金项目资助,2022年获得国家级人才项目资助。


       研究工作围绕生物分子信息精准获技术及仪器展开,包括:

       1.针对精细结构信息获取(空)问题,研究空间分辨测量技术→→→课题:项目电学隧穿探针/芯片、单分子光镊、量子测序

       2.针对实时动态信息获取(时)问题,研究时间分辨测量技术→→→课题:光波驱动电学探测、蛋白实时电导测量、药物筛选

       3.针对微弱特征信息获取(量)问题,研究超高灵敏测量技术→→→课题:纳米孔单分子检测、单分子拉曼

       

      团队长期招聘研究助理或博士后,欢迎不同学科背景人员加盟。目前仍有2023年博士、硕士招生名额,欢迎联系咨询(lhtang@zju.edu.cn)



代表性论文成果

25. Tao Jiang+Biaofeng Zeng+Bintian Zhang, Longhua Tang,*

Single-Molecular Protein-based Bioelectronics via Electronic Transport: Fundamental, Devices and Applications 

Chemical Society Reviews (Impact factor: 60.615), 2022, revised. 


24. Tao Jiang, Xu Liu, Long Yi, Aleksandar P. Ivanov, Joshua B. Edel, and Longhua Tang*

Fabrication of electron tunnelling probes for measuring single protein conductance

Nature Protocols (Impact factor: 17.021), 2022, revised. 


23. Yuxuan Qiu, Cuifang Kuang, Xu Liu, Longhua Tang *

Single-molecule surface-enhanced Raman spectroscopy

Sensors, 2022,22(13), 4889 https://doi.org/10.3390/s22134889   


22. Qiuxiang He and Longhua Tang*  

 Sub-5 nm nanogap electrodes towards single-molecular biosensing

Biosensors & Bioelectronics, 2022,213,114486,  https://doi.org/10.1016/j.bios.2022.114486 

21. Longhua Tang,*  Long Yi, Tao Jiang, Ren Ren, Binoy Paulose Nadappuram, Bintian Zhang,  Jian Wu, Xu Liu, Stuart Lindsay, Aleksandar P. Ivanov* Joshua B. Edel *

Measuring conductance switching in single proteins using quantum tunneling 

Science Advances, 2022,8(20), DOI: 10.1126/sciadv.abm8149


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唐龙华课题组《Science Advances》发文报道基于量子隧穿的单分子蛋白质电导测量技术

浙江大学唐龙华等Sci. Adv.:利用隧穿结器件实现单分子蛋白质长时电导测量


20.  Longhua Tang,* Binoy Paulose Nadappuram, Paolo Cadinu, Zhiyu Zhao, Liang Xue, Long Yi, Ren Ren, Jiangwei Wang,  Aleksandar P. Ivanov,* Joshua B. Edel*

Combined dielectrophoretic trapping and quantum tunnelling for molecular analysis at ultra-low analyte concentrations, 

Nature Communications, 2021, 12, 913  https://doi.org/10.1038/s41467-021-21101-x

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浙江大学唐龙华等Nat. Commun.:结合介电泳捕获的量子隧穿传感技术实现超低浓度的单分子检测


19. Yifan Zhang, Tingjie Song Tao Feng, Yilin Wan,  Nicholas T. Blum, Chengbo Liu, Chunqi Zheng,bTao Jiang, Qiang Li, Jing Lin, Longhua Tang, * Peng Huang, * 

Plasmonic Modulation of Gold Nanotheranostics for Targeted Photothermal-Augmented Immunotherapy in the Second NearInfrared Window, 

Nano Today, 2020 35, 100987 https://doi.org/10.1016/j.nantod.2020.100987 


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DNA编程策略合成金纳米诊疗剂用于近红外二区的光热增强型癌症免疫治疗


18.. Yifan Zhang, Yilin Wan,Yunyan Liao,Yanjie Hu,Tao Jiang, Ting He,Wei Bi,Jing Lin,Peng Gong,Longhua Tang*, and Peng Huang * 

Janus γ-Fe2O3/SiO2-based nanotheranostics for dual-modal imaging and enhanced synergistic cancer starvation/chemodynamic therapy, 

Science Bulletin (IF: 6.277), 2020, 65(7), 564-572  https://doi.org/10.1016/j.scib.2019.12.024 

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17. Xu Liu+, Yilin Wan+, Tao Jiang, Yifang Zhang, Peng Huang*, Longhua Tang*

Plasmon-Activated Nanozymes with Enhanced Catalytic Activity by Near-Infrared Light Irradiation,

 Chemical Communictions (IF: 6.290), 2020, 56, 1784.  doi:10.1039/C9CC08223A. Back cover

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16. Tao Jiang,Pratibha Goel,Hui Zhao,Rui Ma,Linghua Zhu,Xiangjiang Liu,Longhua Tang* 

Internal Structure Tailoring in 3D Nanoplasmonic Metasurface for Surface‐Enhanced Raman Spectroscopy,

Particle & Particle Systems Characterization (IF: 4.194), 2020, 37,  1900345, DOI: 10.1002/ppsc.201900345 (Front Cover)

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15. Hui Zhao+, Misha Liu,+ Tao Jiang, Jinjin Xu, Huirong Zhang, Chaofan Yu, Zipeng Liu, Ying Wang, Longhua Tang*

Ultrasensitive Monitoring of DNA Damage Associated with Free Radicals Exposure Using Dy-namic Carbon Nanotubes Bridged Interdigitated Electrode Array

Environment International (IF:7.943)  , 2020, 139 105672  

 

14. Yiming Zhang, Tao Jiang,  Longhua  Tang*, 

Near-Infrared Photoluminescence Biosensing Platform with Gold Nanorods-over-Gallium Arsenide Nanohorn Array

Biosensors & Bioelectronics, 2017, 97, 278–284


13 . Longhua  Tang, Jinghong Li* 

Plasmon-based Colorimetric Nanosensors for Ultrasensitive Molecular Diagnostics,

ACS Sensors, 2017, 2, 857


12. Fang Yu, Yun Li, Mingyu Li,  Longhua  Tang*, Jian-Jun He,

 DNAzyme-integrated plasmonic nanosensor for bacterial sample-to-answer detection, 

Biosensors & Bioelectronics, 2017, 89, 880-885


11. Xiangjiang Liu, Jingjing Wang, Jiajun Wang, Longhua  Tang*, Yibin Ying,

 Flexible and Transparent Surface-Enhanced Raman Scattering (SERS)-Active Metafilm for Visualizing Trace Molecules via Raman Spectral Mapping,

 Analytical Chemistry, 2016, 88(12): 6166-73


10. Chang Lu, Xiangjiang Liu, Yunfeng Li, Fang Yu,  Longhua  Tang*, Yanjie Hu*, Yibing Ying*,

Multifunctional Janus hematite-silica nanoparticles: mimicking peroxidase-like activity and sensitive colorimetric detection of glucose,

 ACS Applied Materials & Interface, 2015, 7, 15395-402


9.Xiangjiang Liu, Jianjun Wang, Longhua  Tang,* Yichen Wu, Tianren Fan, Yang Xu, Yibin Ying*,

Compact Shielding of Graphene Monolayer Leads to Extraordinary SERS-Active Substrate with Large-Area Uniformity and Long-Term Stability, 

Scientific Reports2015, 30; 5:17167.


8 Longhua  Tang, Ying Wang, and Jinghong Li*, 

The Graphene/Nucleic Acids- Nanobiointerface,

Chemical Society Reviews, 2015, 44(19), 6954-80


7.  Longhua  Tang, Dongyang, Li, Jinghong Li*, 

Graphene Oxide.DNA Duplex−Based Logic Gate and Sensor Mediated by RecA-ssDNA Nucleoprotein Filaments, 

Chem. Commun. 2013, 49, 9971-9973


6. Longhua  Tang, IkSu Chun, Zidong Wang, Jinghong Li*, Xiuling Li*, Yi Lu*, 

Plasmonic Enhanced Near-Infrared Photoluminescence of Gallium Arsenide for DNA Sensing, 

Anal. Chem., 2013, 85, 9522-9527


5. Longhua  Tang, Haixing, Chang, Yang, Liu, and Jinghong Li*,

 Dupxle DNA.Graphene Oxide Biointerface: from Fundamental Understanding to Specific Enzymatic Effects, 

Adv. Funct. Mater., 2012, 22, 3083–308


4. Longhua  Tang, Yang, Liu, Md Monsur Ali, Dong Ku Kang, Weian Zhao*, and Jinghong Li*,

Colorimetric and Ultrasensitive Bioassay Based on a Dual-Amplification System Using Aptamer and DNAzyme, 

Anal. Chem., 2012, 84, 4711-4717


3. Longhua  Tang, Ying Wang, Yang Liu, Jinghong Li*, 

DNA-Directed Self-Assembly of Graphene Oxide for Ultrasensitive Oligonucleotide Assay,

 ACS Nano,2011, 5, 3817–3822


2.  Longhua  Tang, Hongbing Feng, Jinsheng Cheng, Jinghong Li*, 

Uniform and Rich-Wrinkled Electrophoretic Deposited Graphene Film: A Robust Electrochemical Platform for TNT Sensing,

Chem. Commun., 2010, 46, 5882-5884


1.  Longhua  Tang, Ying Wang, Yueming Li, Hongbing Feng, Jin Lu, Jinghong Li*, 

Preparation, Structure and Electrochemical Properties of Graphene Modified Electrode, 

Adv. Funct. Mater., 2009, 19, 2782-2789



专利成果

1. 一种基于两性纳米颗粒的高灵敏度SERS分子检测方法

专利类型:发明专利


2. 一种基于纳米颗粒光热转换效应的激光器热调谐结构

申请号:201820486946.7

专利类型:实用新型专利


3. 基于纳米颗粒光热转换效应的激光器热调谐新方法

申请号:201810306697.3

专利类型:发明专利


4. 三维立体叉指电极

申请号:201810307445.2

专利类型:发明专利


5. 一种新型三维立体叉指电极

申请号:201820487575.4

专利类型:实用新型专利


6. 基于双环谐振腔辅助的马赫-曾德尔干涉仪光学生物传感器

授权号:CN105092531B

授权日期:2017-10-20


7. 基于光学谐振腔与反射型偏振转换器级联的生物传感器

授权号:CN104568839B

授权日期:2017-02-22


8. 一种应用于智能手机上的光波导生物传感器

授权号:CN104155244B

授权日期:2017-05-03


9. 基于光学谐振腔与反射型偏振转换器级联的生物传感器

授权号:CN204330588U

授权日期:2015-05-13


教学工作

1. 研究生必修课《科技写作》(秋学期)

2. 本科生大三/大四 《硅基光子学》(Silicon Photonics), 秋学期 



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