教育背景

2009年9月-2014年12月，博士，生物化学和分子生物学专业，密歇根州立大学，美国

2005年9月-2009年7月，学士，生物化学专业，生命科学学院，南京大学

工作经历

2021年10月起，PI，研究员，生物与分子智造研究院，浙江大学杭州国际科创中心

2018年3月起，PI，“百人计划”研究员、博士生导师，农业与生物技术学院，浙江大学

2015年1月至2018年2月，研究助理、博士后，密歇根州立大学-美国能源部植物研究实验室

奖励荣誉

       2022年，仲英青年学者（唐仲英基金会/浙江大学）

       2021年，青年人才卓越计划（浙江大学杭州国际科创中心）

       2020年，领军型创新团队（浙江省科技厅）

       2019年，优秀人才培育计划（浙江大学农业生命环境学部）

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欢迎研究生和博士后加入！可邮件联系咨询。

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欢迎本科生实习。

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（一）细胞器代谢网络与代谢工程

      叶绿体、线粒体和过氧化物酶体等能量细胞器负责的光合-光呼吸超循环，是有机物和化学能的来源，也是作物高产抗逆和提质增效的能量基础。我们通过遗传学、生物信息学等技术，挖掘能量细胞器代谢网络未知元件和通路，为提高植物光效和抗性提供理论基础；同时开展水稻和烟草为底盘的细胞器代谢工程研究，旨在提高作物产量和营养，或生物制造高价值化合物。

（二）种子与幼苗的逆境代谢调控

      过氧化物酶体是植物响应逆境的重要器官，其复杂的代谢网络尚未被完全认识，尤其在单子叶禾本科作物中缺乏系统研究。我们通过蛋白组学和人工智能算法，挖掘过氧化物酶体的代谢网络，解析其在水稻和油菜的种子发育与发芽、水稻的生物和非生物胁迫响应中的生理功能，并结合代谢工程改良农作物抗逆性或生产农业抗性调节剂。

主要论文（Selected publications）：

• Wang Y, Miao H, Qiu J, Liu M, Jin G, Zhang W, Song S, Fan P, Xin X, Hu J, Li R*, Pan R* (2024). Species- and organ-specific contribution of peroxisomal cinnamate:CoA ligases to benzoic and salicylic acid biosynthesis and function in Arabidopsis and rice. The Plant Cell, in press. (中科院生物1区)
  

• Wang Y#, Jin G#, Song S#, Jin Y, Wang X, Yang S, Shen X, Gan Y, Wang Y, Li R, Liu J, Hu J, Pan R* (2024). A peroxisomal cinnamate:CoA ligase-dependent phytohormone metabolic cascade in submerged rice germination. Developmental Cell, 59(11), 1363-1378. (中科院生物1区) (full)

[Comment: Wright Z, Bartel B# (2024). Hormonal control of underwater germination in rice. Developmental Cell, 59(11), 1361-1362.]

[Comment: He Y, Zhao J, Wang Z# (2024). Rice seed germination priming by salicylic acid and the emerging role of phytohormones in anaerobic germination. Journal of Integrative Plant Biology, 66(8), 1537-1539.]

• Song S#, Ye C#, Jin Y, Dai H, Hu J, Lian J*, Pan R* (2024). Peroxisome-based Metabolic Engineering for Biomanufacturing and Agriculture. Trends in Biotechnology, 42(9), 1161-1176. (中科院工程技术1区) (full)
  

• Pan R, Satkovich J, Hu J* (2016). The E3 ubiquitin ligase SP1 regulates peroxisome biogenesis in Arabidopsis. Proceedings of the National Academy of Sciences, 113(46), E7307-E7316. (中科院综合1区)

• Pan R, Jones AD, Hu J* (2014). Cardiolipin-mediated mitochondrial dynamics and stress response in Arabidopsis. The Plant Cell, 26(1), 391–409. (中科院生物1区)

• Deng Q#, Hong X#, Xia Y#, Gong Z#, Dai H, Chen J, Feng Y, Zhang J, Xie X, Li N, Shen X, Hu J, Zhang Q*, Lang X*, Pan R* (2024). Comprehensive identification of plant Peroxisome Targeting Signal type 1 tripeptides. New Phytologist, 243(5), 1642-1650. (中科院生物1区) (full)

• Wu J#, Deng Q#, Qiu Y#, Liu C, Lin C, Ru Y, Sun Y, Lai J, Liu L, Shen X, Pan R*, Zhao Y* (2024). Post-transfer adaptation of HGT-acquired genes and contribution to guanine metabolic diversification in land plants. New Phytologist, 244(2), 694-707. (中科院生物1区) (full)

• Wang Y, Pan R*, Hu J* (2024).  Impact of acute heat stress on mitochondrial function, ultra-structure and cardiolipin distribution in Arabidopsis. aBiotech, 5, 362-367. (full) 

• Akhter D#, Zhang Y#, Hu J*, Pan R* (2023). Protein ubiquitination in plant peroxisomes. Journal of Integrative Plant Biology, 65(2):371-380. (中科院生物1区) (full)

• Feng Y#, Wang Y#, Lu H#, Li J, Akhter D, Liu F, Zhao T, Shen X, Li X, Whelan J, Zhang T, Hu J, Pan R* (2023). Assembly and phylogenomic analysis of cotton mitochondrial genomes provide insights into the history of cotton evolution. Crop Journal, 11(6): 1782-1792. (中科院农学1区) (full)

• Deng Q#, Li H#, Feng Y#, Xu R, Li W, Zhu R, Akhter D, Shen X, Hu J*, Jiang H*, Pan R* (2022). Defining upstream enhancing and inhibiting sequence patterns for plant Peroxisome Targeting Signal type 1 using large-scale in silico and in vivo analyses. The Plant Journal, 111(2), 567-582. (中科院生物1区) (full) 

• Pan R, Liu J, Wang S, Hu J* (2020) Peroxisomes: versatile organelles with diverse roles in plants, New Phytologist, 225 (4), 1410-1427. (中科院生物1区)
  

• Pan R*, Liu J, Hu J* (2019) Peroxisomes in plant reproduction and seed-related development. Journal of Integrative Plant Biology, 61 (7), 784-802. (中科院生物1区) (full) 

• Pan R#, Reumann S#, Lisik P, Tietz S, Olsen L, Hu J* (2018). Proteome analysis of peroxisomes from dark-treated senescent Arabidopsis leaves. Journal of Integrative Plant Biology, 60(11), 1028-1050. (中科院生物1区)
  

• Pan R, Satkovich J, Chen C, Hu J* (2018). The E3 ubiquitin ligase SP1-Like 1 plays a positive role in peroxisome biogenesis in Arabidopsis. The Plant Journal, 94, 836-846. (中科院生物1区)

• Pan R, Hu J* (2018). The Arabidopsis E3 Ubiquitin Ligase SP1 Targets to Chloroplasts, Peroxisomes, and Mitochondria. Plant Physiology, 176(1), 480-482. (中科院生物1区)

• Pan R, Kaur N, Hu J* (2014). The Arabidopsis mitochondrial membrane-bound ubiquitin protease UBP27 contributes to mitochondrial morphogenesis. The Plant Journal, 78(6), 1047-1059. (中科院生物1区)

• Deng Q, Jiang H, Hu J, Pan R* (2024). Identification of Auxiliary Organellar Targeting Signals for Plant Peroxisomes Using Bioinformatic Analysis of Large Protein Sequence Datasets Followed by Experimental Validation. Methods in Molecular Biology, 2792, 265-275. (full)

• Zhang Y#, Wang X#, Wang X, Wang Y, Liu J, Wang S, Li W, Jin Y, Akhter D, Chen J, Hu J, Pan R* (2023), Bioinformatic analysis of short-chain dehydrogenase/reductase proteins in plant peroxisomes. Frontiers in Plant Science, 14, 1180647. (full)

• Pan R, Hu J* (2018). Proteome of plant peroxisomes. Subcellular Biochemistry, 89, 3-45.

• Tao M#, Chen J#, Cui C#, Xu Y#, Xu J, Shi Z, Yun J, Zhang J, Ou G, Liu C, Chen Y, Zhu Z, Pan R, Xu S, Chen X, Rokas A, Zhao Y, Wang S*, Huang J*, Shen X* (2024). Identification of a longevity gene through evolutionary rate covariation of insect mito-nuclear genomes. Nature Aging, 4(8), 1076-1088. 
  

• Li W, Liu J, Li Z, Ye R, Chen W, Huang Y, Yuan Y, Zhang Y, Hu H, Zheng P, Fang Z, Tao Z, Song S, Pan R, Zhang J, Tu J, Sheen J, Du Hao* (2024). Mitigating growth-stress tradeoffs via elevated TOR signaling in rice. Molecular Plant, 17(2), 240-257. 

• Ma B, Lu C, Wang Y, Yu J, Zhao K, Xue R, Ren H, Lv X, Pan R, Zhang J, Zhu Y, Xu J (2023). A genomic catalogue of soil microbiomes boosts mining of biodiversity and genetic resources. Nature Communications, 14(1), 7318. 
  

• Zheng P#, Ge J#, Ji J, Zhong J, Chen H, Luo D, Li W, Bi B, Ma Y, Tong W, Han L, Ma S, Zhang Y, Wu J, Zhao Y, Pan R, Fan P, Lu M, Du H* (2023). Metabolic engineering and mechanical investigation of enhanced plant autoluminescence. Plant Biotechnology Journal, 21(8), 1671-1681. 

• Li Y#, Liu Z#, Liu C#, Shi Z, Pang L, Chen C, Chen Y, Pan R, Zhou W, Chen X, Rokas A*, Huang J*, Shen X* (2022). HGT is widespread in insects and contributes to male courtship in lepidopterans. Cell, 185 (16), 2975-2987. 
  

• Lin Y, Li P, Zhang Y, Akhter D, Pan R, Fu Z, Huang M, Li X, Feng Y* (2022). Unprecedented organelle genomic variations in morning glories reveal independent evolutionary scenarios of parasitic plants and the diversification of plant mitochondrial complexes. BMC biology, 20(1), 1-16.

• Li Z., Liu H., Ding Z., Yan J., Yu H., Pan R., Hu J., Guan Y., Hua J. (2020) Low temperature enhances plant immunity via salicylic acid pathway genes that are repressed by ethylene. Plant Physiology, 182 (1), 626-639.
  

• Ma W., Guan X., Li J., Pan R., Wang L., Liu F., Ma H., Zhu S., Hu J., Ruan Y., Chen X., Zhang T.* (2019) Mitochondrial Small Heat Shock Protein Mediates Seed Germination via Thermal Sensing. Proceedings of the National Academy of Sciences, 116 (10), 4716-4721.

• He F., Gao C., Guo G., Liu J., Gao Y., Pan R., Guan Y.*, Hu J. (2019) Maize annexin genes ZmANN33 and ZmANN35 encode proteins that function in cell membrane recovery during seed germination. Journal of Experimental Botany, 70(4), 1183-1195.

• Desai M., Pan R., Hu J.* (2017). Arabidopsis Forkhead-Associated Domain Protein 3 negatively regulates peroxisome division. Journal of Integrative Plant Biology, 59(7), 454.

博士后（postdoc）：

朱仪方（南京农业大学/植生所）；宋书言（南京大学/入选博新计划）；王玉康（浙江大学）；台莉（西北农林大学）

研究生（graduate student）：

刘军；韩京京；邓倩文；王晓雯；金益君

朱霞；夏雨清；王欣瑜；陈佳荣；朱万欣；MH Rifat

（一）本科生课程

                               种子学

                               种子生物学

                               学术英文写作

（二）研究生课程

                               作物科学研究理论与方法

                               种子科学研究进展

                               种子科学与技术

左--->右：

王赛赛（硕士）；徐若楠（硕士）；Delara Akhter（博士后，现任锡尔赫特农业大学教授）；冯彦磊（博士后，现任浙大杭州国际科创中心研究员）；李未然（硕士）。

左--->右：

张钰婵（博士，现任上海市食品药品检验研究院博士后）。