Profile

     Zhuoxian Meng is a tenure-track professor and PhD mentor at the Department of Pathology and Pathophysiology. Prior to joining ZJU, he worked as a Postdoc Research Fellow and a Research Investigator at the University of Michigan. His laboratory is investigating the transcriptional networks and signaling pathways that control energy metabolism in both physiological and pathological states. His long-term career goal is to elucidate the molecular basis of obesity and diabetes, and to find new clues for the therapy of these disorders.

Research Directions                
1) Molecular mechanism of obesity and type 2 diabetes
2) Epigenetic regulation of nutrient sensing and energy metabolism
3) Role and mechanism of metabolic homeostasis in skeletal muscle development,
muscle damage and repair, the

     pathogenesis of type 2 diabetes
4) Molecular mechanism of pancreatic β dysfunction in diabetes


Education

2004.09-2009.07          Ph.D. in Biochemistry and Molecular Biology, Nanjing Medical University, China
1999.09-2004.07          M.D. in Clinical Medicine, Nanjing Medical University, China

                                  
Professional Experience
2016-                  Professor, Principal Investigator,
                  
        Department of Pathology and Pathophysiology School of Basic Medical Sciences, Zhejiang

                           University   
                           Research Focus: Molecular mechanisms of obesity and diabetes
2014-2015         Research Investigator,
                           Life Sciences Institute, University of Michigan
                           Research Focus: Role of chromatin remodeling cofactors in metabolic
control and diseases

2009-2014         Postdoctoral Research Fellow,
                           Life Sciences Institute, University of Michigan
                           Research Focus: Regulation of energy metabolism by SWI/SNF
chromatin remodeling cofactors

2004-2009         Graduate Student,
                           Department of Biochemistry and Molecular Biology,
Nanjing Medical University                          
                           Research Focus: Roles of inflammation and glucolipotoxicity in
pancreatic β Cell failure in 

                           diabetes  

2002-2004         Residency,
                           The first hospital of Jiangsu province/the first hospital of Lianyungang city,
China
1999-2004         Medical Student,
                           School of Clinical Medicine, Nanjing Medical University, China


Representative Publications

1) Meng ZX, Gong J, Chen Z, Sun J, Xiao Y, Wang L, Li Y, Liu J, Xu X.Z.S, Lin J (2017) Glucose sensing by skeletal myocytes couples nutrient signaling to systemic homeostasis. Molecular CellMay 4;66(3):332-344. (Cover story)


2) Meng ZX*, Wang L, Chang L, Sun JX, Bao J, Li Y, Chen YE, Lin JD* (2015) A diet sensitive Baf60a-mediated pathway links bile acid metabolism to atherosclerosis. Cell Reports. 13: 1-12.(*co-corresponding author)


3) Wang GX, Zhao XY, Meng ZX, Kern M, Dietrich A, Chen Z, Cozacov Z, Zhou D, Okunade AL, Su X, Li S, Blüher M, Lin JD (2014) The brown fat–enriched secreted factor Nrg4 preserves metabolic homeostasis through attenuation of hepatic lipogenesis. Nature Medicine. 20:1436-43.


4) Meng ZX, Wang L, Xiao Y, Lin JD (2014) The Baf60c/Deptor Pathway Links Skeletal Muscle Inflammation to Glucose Homeostasis in Obesity. Diabetes. 63:1533-45.


5) Meng ZX, Li S, Wang L, Ko HJ, Lee Y, Okutsu M, Yan Z, Kim, JK, Lin JD (2013) Baf60c drives glycolytic metabolism in the muscle and improves systemic glucose homeostasis through Deptor-mediated Akt activation. Nature Medicine. 19: 640-5.


6) Meng ZX, Wang GX, Lin JD (2012) A microRNA circuitry links macrophage polarization to metabolic homeostasis. Circulation. 125: 2815-7.


7) Meng ZX, Yin Y, Lv JH, Sha M, Lin Y, Gao L, Zhu YX, Sun YJ, Han X (2012) Aberrant activation of liver X receptors impairs pancreatic beta cell function through upregulation of sterol regulatory element-binding protein 1c in mouse islets and rodent cell lines. Diabetologia. 55: 1733-44.


8) Meng ZX, Lv J, Luo Y, Lin Y, Zhu Y, Nie J, Yang T, Sun Y, Han X (2009) Forkhead box O1/pancreatic and duodenal homeobox 1 intracellular translocation is regulated by c-Jun N-terminal kinase and involved in prostaglandin E2-induced pancreatic beta-cell dysfunction. Endocrinology. 150: 5284-93.


9) Meng ZX, Nie J, Ling JJ, Sun JX, Zhu YX, Gao L, Lv JH, Zhu DY, Sun YJ, Han X (2009) Activation of liver X receptors inhibits pancreatic islet beta cell proliferation through cell cycle arrest. Diabetologia. 52: 125-35.


10
) Meng ZX, Sun JX, Ling JJ, Lv JH, Zhu DY, Chen Q, Sun YJ, Han X (2006) Prostaglandin E2 regulates Foxo activity via the Akt pathway: implications for pancreatic islet beta cell dysfunction. Diabetologia. 49: 2959-68.

Contact

Phone:0571-8898 1141
E-mail:zxmeng@zju.edu.cn