个人陈述

2004年和2009年分别获得南京医科大学临床医学学士和理学博士学位。2009-2015年先后任美国密歇根大学生命科学研究院博士后和研究员。2015年入选国家“青年千人计划”（择优资助）和浙江大学“百人计划”。2016年入选“浙江省千人计划”。2016年2月聘为浙江大学研究员、博士生导师。2017年获得国家“优秀青年基金“资助。2020年当选为北美华人糖尿病学会执委（CADA board member）。专注于糖脂代谢时空调控，以及肥胖和糖尿病分子机制研究17余年，取得了一系列有国际影响力的研究成果，以第一和通讯作者（包括共同）在Nature Medicine (2013)、Molecular Cell (2017)、Circulation (2012)、JEM (2022)、PNAS (2022)、Cell Reports (2015)、Diabetes (2014, 2018, 2022)、Diabetologia (2006, 2009, 2012)、Protein Cell (2018), JMCB (2022a, 2022b)等国际权威杂志发表高水平学术论文24篇，以共同作者身份发表SCI论文21篇。论文被Cell、Science、Nature Medicine等期刊引用1500余次。担任北美华人糖尿病协会执委，中国生物化学与分子生物学会代谢专业分会副主任委员，中国生物物理学会脂质代谢与生物能学分会理事，中国病理生理学会内分泌与代谢专业委员会委员。在美国工作期间先后获得美国心脏病学会博士后奖学金（AHA Postdoc Fellowship）和科学家发展奖（AHA SDG Award）。担任Diabetes、Molecular Metabolism、Diabetologia、JBC、JMCB等多个国际权威杂志的特约申稿专家。担任国家自然科学基金面上项目、重点国合项目、英国国家自然科学基金项目（BBSRC）等国内外多个基金项目的评审专家。

研究方向

       目前课题组重点研究在正常生理情况下和糖尿病发病过程中细胞能量感受（nutrient sensing）和代谢重编程（metabolic reprogramming）的转录调控网络和信号转导机制，及其在糖尿病发生发展过程中的作用，旨在为糖尿病的诊断和治疗提供新的理论基础和药物靶标，具体如下：

1.    2型糖尿病胰岛β细胞功能损伤的分子机制和治疗策略

2.    分泌因子介导的组织、细胞间对话的在组织稳态和代谢调控中的作用和机制

3.    骨骼肌代谢可塑性在骨骼肌再生和糖尿病发病过程中的作用和机制

4.    染色质重塑介导的表观遗传学机制在细胞能量感受和代谢调控中作用和意义

教育经历

1.    2004.09–2009.07  南京医科大学，生物化学与分子生物学系，博士

2.    1999.09–2004.07  南京医科大学，临床医学系，学士

科研与学术工作经历

1.    2024.12–               浙江大学，医学院 长聘正教授

2.    2023.06–2024.11  浙江大学，医学院 长聘副教授

3.    2022.04–               浙江大学附属第二医院，双聘教授

4.    2018.08–2022.03  浙江大学附属第一医院，双聘教授

5.    2016.02–               浙江大学，医学院病理与病理生理学系，研究员

6.    2014.02–2016.01  美国密歇根大学，研究员（Research Investigator)

7.    2009.07–2014.01  美国密歇根大学，博士后

代表论文

1. Long A, Guo Y, Hong J, Ning G, Meng Z*, Wang J*, Wang Y* (2024) A Famsin-Glucagon Axis Mediates Glucose Homeostasis. Cell Metabolism, Dec 12:S1550-4131(24)00454-6. doi: 10.1016/j.cmet.2024.11.008.

2. Zhong J, Ji X, Zhao Y, Jia Y, Song C, Lv J, Chen Y, Zhou Y, Lv X, Yang Z, Zhang Z, Xu Q, Wang W, Chen H, Cui A, Li Y, Meng ZX* (2024) Identification of BAF60b as a chromatin remodeling checkpoint of diet-induced fatty liver disease. Diabetes. Jul 24:db240002. Online ahead of print.

3. Chen Z, Weng Z, Lin JD*, Meng ZX* (2024) Myokines: metabolic regulation in obesity and type 2 diabetes. Life Metabolism, June 3(3), loae006.(特邀综述)

4.    Lv Y^#, Xu J^#, Li Y^#, Wang R^#, Dai C^#, Zhang B, Zhang X, Xu L, Tao Y, Han M, Guo R, Wu Q, Wu L*, Meng ZX*, Tan M*, Li J* (2024) DRAK2 suppresses autophagy by phosphorylating ULK1 at Ser56 to diminish pancreatic β cell function upon overnutrition. Science Translational Medicine, Feb 7;16(733):eade8647. doi: 10.1126/scitranslmed.ade8647. IF=19.3

5.    Pan X^#, Ye L^#, Guo X, Wang W, Zhang Z, Wang Q, Huang J, Xu J, Cai Y, Shou X, Wang Y, Feng Y, Xie C, Shan P*, Meng ZX* (2023) Glutamine production by Glul promotes thermogenic adipocyte differentiation through Prdm9-mediated H3K4me3 and transcriptional reprogramming. Diabetes. Nov 1;72(11):1574-1596. IF=9.3

6.    Jin L^#, Han S^#, Lv X^#, Li X^#, Zhang Z, Kuang H, Chen Z, Lv C, Peng W, Yang Z, Yang M, Mi L, Liu T, Ma S, Qiu X, Wang Q, Pan X, Shan P, Feng Y, Li J, Wang F, Xie L, Zhao X, Fu J*, Lin JD, Meng ZX* (2023) The muscle-enriched myokine Musclin impairs beige fat thermogenesis and systemic energy homeostasis via Tfr1/PKA signaling. Nature Communications, Jul 19;14(1):4257. doi: 10.1038/s41467-023-39710-z., IF=17.7

7.    Sun M^#, Wan Y^#, Shi M^#, Meng ZX*, Zeng W* (2023) Neural innervation in adipose tissue, gut, pancreas, and liver. Life Metabolism, June 6, published online, https://doi.org/10.1093/lifemeta/load022

8.    Xu J^#, Li X^#, Chen W^#, Zhang Z, Zhou Y, Gou Y, Lv C, Qiu X, Ma S, Wu Q, Liu T, Mi L, Yang Z, Yu T, Pan X, Feng Y*, Shan P*, Meng ZX* (2023) Myofiber Baf60c controls muscle regeneration by modulating Dkk3-mediated paracrine signaling. Journal of Experimental Medicine, Sep 4;220(9):e20221123. doi: 10.1084/jem.20221123. Epub 2023 Jun 7., IF=17.6

9.    Han S^#, Wu QQ^#, Wang M^#, Yang M, Sun C, Liang J, Guo X, Zhang Z, Xu J, Qiu X, Xie C, Chen S, Gao Y*, Meng ZX* (2023) Integrative profiling of the metabolome and transcriptome in plasma and skeletal muscle following exercise intervention in diet-induced obese mice. Journal of Molecular Cell Biology. Mar 7;mjad016. doi: 10.1093/jmcb/mjad016. Online ahead of print. IF=8.2

10.    Lv C, Sun Y, Zhang ZY, Aboelela Z, Qiu X*, Meng ZX* (2022) β-cell dynamics in type 2 diabetes and in dietary and exercise interventions. Journal of Molecular Cell Biology, Nov 30;14(7):mjac046. doi: 10.1093/jmcb/mjac046. IF=8.2

11.    Kong Q^#, Zou J^#, Zhang Z, Pan R, Xu Y, Gao Y*, Meng ZX* (2022) BAF60a deficiency in macrophage promotes diet-induced obesity and metabolic inflammation. Diabetes, Oct 1;71(10):2136-2152. doi: 10.2337/db22-0114. IF=9.3

12. Wang RR, Fu H, Li J*, Meng ZX* (2022) Comments on ‘Dietary intervention preserves β cell function in mice through CTCF-mediated transcriptional reprogramming.’ Journal of Molecular Cell Biology, Sep 27;14(7):mjac043. doi: 10.1093/jmcb/mjac043. IF=8.2

13. Wang RR^#, Qiu X^#, Pan R^#, Fu H^#, Wang Q, Zhang Z, Chen H, Wu QQ, Pan X, Wang S, Shan P, Guo G, Zheng M, Zhu L*, Meng ZX* (2022) Dietary Intervention Preserves β-cell Function Through CTCF-mediated Transcriptional Reprogramming. Journal of Experimental Medicine, Jul 4;219(7):e20211779. doi: 10.1084/jem.20211779. Epub 2022 Jun 2. IF=17.6 (Cover story)

14. Zhang Z, Gao Y*, Meng ZX* (2022) Transcriptional control of pancreatic β-cell identity and plasticity during the pathogenesis of type 2 diabetes. Journal of Genetics and Genomics, Apr;49(4):316-328. doi: 10.1016/j.jgg.2022.03.002. IF=5.7

15. Qiao J^#, Zhang Z^#, Ji S^#, Liu T, Zhang X, Huang Y, Feng W, Wang K, Wang J, Wang S, Meng ZX*, Liu M* (2022) A distinct role of STING in regulating glucose homeostasis through insulin sensitivity and insulin secretion. PNAS, Feb 15;119(7):e2101848119. doi: 10.1073/pnas.2101848119. IF=12.8

16. Yang F, Duan M, Zheng F, Yu L, Wang Y, Wang G, Lin J, Han S, Gan D, Meng Z*, Zhu S* (2021) Fas signaling in adipocytes promotes low-grade inflammation and lung metastasis of colorectal cancer through interaction with Bmx. Cancer Letters. Dec 1;522:93-104. doi: 10.1016/j.canlet.2021.09.024. Epub 2021 Sep 16. IF=9.8

17. Wang J^#, Chen Y^#, Pan R, Wu Chao, Chen S, Li L, Li Y, Yu C, Meng ZX*, Xu C* (2021) Leukocyte cell-derived chemotaxin 2 promotes the development of nonalcoholic fatty liver disease through STAT-1 pathway in mice. Liver Int., Apr;41(4):777-787. doi: 10.1111/liv.14816. Epub 2021 Feb 23. IF=8.8

18. Han S, Wu P, Duan M, Yang F, He W, Wu N, Hu X, Gan D, Wang G, Yang M, Wang W, Meng ZX*, Zhu S* (2021) The crosstalk between platelets and body fat: A reverse translational study. Clinical Nutrition. Apr;40(4):2025-2034. doi: 10.1016/j.clnu.2020.09.023. IF=7.6

19. Tang L^#, Wang H^#, Dai B, Wang X, Zhou D, Shen J, Guo F, Wang J, Zhou J, Wang H, Wu Q, Yao H, Gong T, Su J, Meng ZX*, Niu T*, Zhang L*, Liang P* (2020) Human induced pluripotent stem cell-derived cardiomyocytes reveal abnormal TGFβ signaling in type 2 diabetes mellitus. J Mol Cell Cardiol. May;142:53-64. doi: 10.1016/j.yjmcc.2020.03.016. IF=5.8

20. Li Y, Deng S, Peng J, Wang X, Essandoh K, Mu X, Peng T, Meng ZX*, Fan GC* (2019) MiR-223 is essential for maintaining functional β-cell mass during diabetes through targeting unique bipartite Foxo1 and Sox6 pathways. Journal of Biological Chemistry. Jul 5;294(27):10438-10448. doi: 10.1074/jbc.RA119.007755. IF=5.5

21. Wang RR^#, Pan R^#, Zhang W, Fu J, Lin JD, Meng ZX* (2018) The SWI/SNF chromatin-remodeling factors BAF60a, b, and c in nutrient signaling and metabolic control. Protein Cell. Feb;9(2):207-215. doi: 10.1007/s13238-017-0442-2. (特邀综述), IF=15.3

22. Meng ZX*, Tao W, Sun J, Wang Q, Mi L, Lin JD* (2018) Uncoupling exercise bioenergetics from systemic metabolic homeostasis by conditional inactivation of Baf60s in skeletal muscle. Diabetes. Jan;67(1):85-97. doi: 10.2337/db17-0367. IF=9.3

23. Meng ZX, Gong J, Chen Z, Sun J, Xiao Y, Wang L, Li Y, Liu J, Xu X.Z.S, Lin JD* (2017) Glucose sensing by skeletal myocytes couples nutrient signaling to systemic homeostasis. Molecular Cell. May 4;66(3):332-344.e4. doi: 10.1016/j.molcel.2017.04.007. (浙大第一单位，封面文章). IF=19.3

24. Meng ZX*, Wang L, Chang L, Sun JX, Bao J, Li Y, Chen YE, Lin JD* (2015) A diet sensitive Baf60a-mediated pathway links bile acid metabolism to atherosclerosis. Cell Reports. 13: 1-12. (*共同通讯作者) IF=9.9

25. Wang GX, Zhao XY, Meng ZX, Kern M, Dietrich A, Chen Z, Cozacov Z, Zhou D, Okunade AL, Su X, Li S, Blüher M, Lin JD* (2014) The brown fat–enriched secreted factor Nrg4 preserves metabolic homeostasis through attenuation of hepatic lipogenesis. Nature Medicine, 20:1436-43.

26. Meng ZX, Wang L, Xiao Y, Lin JD* (2014) The Baf60c/Deptor Pathway Links Skeletal Muscle Inflammation to Glucose Homeostasis in Obesity. Diabetes, 63:1533-45. IF=9.3

27. Meng ZX, Li S, Wang L, Ko HJ, Lee Y, Okutsu M, Yan Z, Kim, JK, Lin JD* (2013) Baf60c drives glycolytic metabolism in the muscle and improves systemic glucose homeostasis through Deptor-mediated Akt activation. Nature Medicine, 19: 640-5. IF=87.2

28. Meng ZX, Wang GX, Lin JD* (2012) A microRNA circuitry links macrophage polarization to metabolic homeostasis. Circulation, 125: 2815-7. IF=39.9

29. Meng ZX, Yin Y, Lv JH, Sha M, Lin Y, Gao L, Zhu YX, Sun YJ, Han X* (2012) Aberrant activation of liver X receptors impairs pancreatic beta cell function through upregulation of sterol regulatory element-binding protein 1c in mouse islets and rodent cell lines. Diabetologia, 55: 1733-44. IF=10.5

30. Meng ZX, Lv J, Luo Y, Lin Y, Zhu Y, Nie J, Yang T, Sun Y, Han X* (2009) Forkhead box O1/pancreatic and duodenal homeobox 1 intracellular translocation is regulated by c-Jun N-terminal kinase and involved in prostaglandin E2-induced pancreatic beta-cell dysfunction. Endocrinology, 150: 5284-93. IF=5.1

31. Meng ZX, Nie J, Ling JJ, Sun JX, Zhu YX, Gao L, Lv JH, Zhu DY, Sun YJ, Han X* (2009) Activation of liver X receptors inhibits pancreatic islet beta cell proliferation through cell cycle arrest. Diabetologia, 52: 125-35. IF=10.5

32. Meng ZX, Sun JX, Ling JJ, Lv JH, Zhu DY, Chen Q, Sun YJ, Han X* (2006) Prostaglandin E2 regulates Foxo activity via the Akt pathway: implications for pancreatic islet beta cell dysfunction. Diabetologia, 49: 2959-68. IF=10.5

出版教材

1. 《肌肉内分泌学》

主编：孙子林、孟卓贤

副主编：张勇、王红星、于康、邱山虎

中国科学技术出版社，2021年3月第一版

总字数：18.4万字，本人负责字数：4万字