Zhuoxian Meng is a tenure-track professor and PhD mentor at the Department of Pathology and Pathophysiology at Zhejiang University School of Medicine. Prior to joining Zhejiang University, he worked as a Postdoc Research Fellow and a Research Investigator at University of Michigan. Research in his laboratory is focusing on the transcriptional networks and signaling pathways that control energy metabolism in both physiological and pathological states. His long-term career goal is to elucidate the molecular basis of obesity and diabetes, and to find clues for new therapeutic interventions for these disorders.

Education

2004.09-2009.07          Ph.D. in Biochemistry and Molecular Biology, Nanjing Medical University, China
1999.09-2004.07          M.D. in Clinical Medicine, Nanjing Medical University, China
                                  
Professional Experience
2016-                  Professor, Principal Investigator,
                           Department of Pathology and Pathophysiology School of Basic Medical Sciences, Zhejiang University    

                           Research Focus: Molecular mechanisms of obesity and diabetes

2014-2015          Research Investigator,
                        Life Sciences Institute, University of Michigan
                        Research Focus: Role of chromatin remodeling cofactors in metabolic control and diseases

2009-2014         Postdoctoral Research Fellow,
                        Life Sciences Institute, University of Michigan
                           Research Focus: Regulation of energy metabolism by SWI/SNF chromatin remodeling cofactors

2004-2009          Graduate Student,
                              Department of Biochemistry and Molecular Biology, Nanjing Medical University                          
                           Research Focus: Roles of inflammation and glucolipotoxicity in pancreatic β Cell failure in diabetes    

2002-2004          Residency,
                        The first hospital of Jiangsu province/the first hospital of Lianyungang city,China
1999-2004          Medical Student,
                         School of Clinical Medicine, Nanjing Medical University, China

Representative Publications

1.    Wang RR#, Pan R#, Zhang W, Fu J, Lin JD, Meng ZX* (2018) The SWI/SNF chromatin-remodeling factors BAF60a, b, and c in nutrient signaling and metabolic control. Protein Cell. Feb;9(2):207-215. (Invited review) (*corresponding author)

2.      Meng ZX*, Tao W, Sun J, Wang Q, Mi L, Lin JD* (2018) Uncoupling exercise bioenergetics from systemic metabolic homeostasis by conditional inactivation of Baf60s in skeletal muscle. Diabetes. Jan;67(1):85-97, *co-corresponding author

3.      Meng ZX, Gong J, Chen Z, Sun J, Xiao Y, Wang L, Li Y, Liu J, Xu X.Z.S, Lin J (2017) Glucose sensing by skeletal myocytes couples nutrient signaling to systemic homeostasis. Molecular Cell. May 4;66(3):332-344. (Cover story)

4.      Meng ZX*, Wang L, Chang L, Sun JX, Bao J, Li Y, Chen YE, Lin JD* (2015) A diet sensitive Baf60a-mediated pathway links bile acid metabolism to atherosclerosis. Cell Reports. 13: 1-12.(*co-corresponding author)

5.      Wang GX, Zhao XY, Meng ZX, Kern M, Dietrich A, Chen Z, Cozacov Z, Zhou D, Okunade AL, Su X, Li S, Blüher M, Lin JD (2014) The brown fat–enriched secreted factor Nrg4 preserves metabolic homeostasis through attenuation of hepatic lipogenesis. Nature Medicine. 20:1436-43.

6.      Meng ZX, Wang L, Xiao Y, Lin JD (2014) The Baf60c/Deptor Pathway Links Skeletal Muscle Inflammation to Glucose Homeostasis in Obesity. Diabetes. 63:1533-45.

7.      Meng ZX, Li S, Wang L, Ko HJ, Lee Y, Okutsu M, Yan Z, Kim, JK, Lin JD (2013) Baf60c drives glycolytic metabolism in the muscle and improves systemic glucose homeostasis through Deptor-mediated Akt activation. Nature Medicine. 19: 640-5.

8.      Meng ZX, Wang GX, Lin JD (2012) A microRNA circuitry links macrophage polarization to metabolic homeostasis. Circulation. 125: 2815-7.

9.      Meng ZX, Yin Y, Lv JH, Sha M, Lin Y, Gao L, Zhu YX, Sun YJ, Han X (2012) Aberrant activation of liver X receptors impairs pancreatic beta cell function through upregulation of sterol regulatory element-binding protein 1c in mouse islets and rodent cell lines. Diabetologia. 55: 1733-44.

10.   Meng ZX, Lv J, Luo Y, Lin Y, Zhu Y, Nie J, Yang T, Sun Y, Han X (2009) Forkhead box O1/pancreatic and duodenal homeobox 1 intracellular translocation is regulated by c-Jun N-terminal kinase and involved in prostaglandin E2-induced pancreatic beta-cell dysfunction. Endocrinology. 150: 5284-93.

11.   Meng ZX, Nie J, Ling JJ, Sun JX, Zhu YX, Gao L, Lv JH, Zhu DY, Sun YJ, Han X (2009) Activation of liver X receptors inhibits pancreatic islet beta cell proliferation through cell cycle arrest. Diabetologia. 52: 125-35.

12.   Meng ZX, Sun JX, Ling JJ, Lv JH, Zhu DY, Chen Q, Sun YJ, Han X (2006) Prostaglandin E2 regulates Foxo activity via the Akt pathway: implications for pancreatic islet beta cell dysfunction. Diabetologia. 49: 2959-68.