许志宏-Zhejiang University Personal homepage

许志宏博士

长聘研究员 | 博士生导师 | 遗传学研究所副所长

更新时间：2025-12-03 | 总访问量：85277

单位 “一带一路”国际医学院（筹）

电话 19521516916
邮箱 ch_hsu@zju.edu.cn
地址紫金港生物实验中心515-516
研究方向
- 表观遗传学

个人简介

许志宏 博士生导师

浙江大学遗传学研究所副所长(长聘研究员，PI)

浙江大学国际医学院遗传医学中心研究员

浙江大学医学院附属第四医院双聘教授

浙江大学国际健康医学研究院研究员

浙江省特聘专家

教育及工作经历

2011/09-2017/10 美国哈佛医学院，Yang Shi院士团队，研究员

2008/07-2011/08 中国台湾中央研究院基因体研究中心,阮丽蓉教授课题组,博士后研究员

2006/10-2007/06 中国台湾中央研究院基因体研究中心,阮丽蓉教授课题组,博士后研究员

2001/09-2006/09 中国台湾清华大学，分子与细胞生物学，博士

主要学术方向

长期致力于研究环境因子（紫外线、病毒、温度、环境污染物等）和表观遗传的互做机制，通过系统性研究表观修饰应答化学、物理、生物性环境因子的调控机制，提出“修饰RNA为环境刺激易感分子”（《Epitranscriptomics》2021），是对阐明环境如何与基因互作而影响表型这个经典生物学问题的重要补充。相关科研成果以主要作者身份发表于National Science Review、Nature、Cell Reports（两篇，其中之一为封面文章）、ES＆T、Blood Cancer Discovery、EMBO Journal、Nature Communications、Research、Oncogene、Nucleic Acids Research等期刊。也以共同作者身份在Cell（封面文章）、Science、Cancer Discovery、Cancer Research等学术期刊上发表多项重要工作。其研究成果多次获重要第三方点评，如：Nature Reviews (两次)、Cell (两次)、Science、Cancer Discovery (两次)、Blood Cancer Discovery、EurekAlert!、Science Signaling和F1000 (两次)等。並有两篇论文分别入选Nature和Cell Reports的特辑。

科研项目

1.国家自然科学基金面上项目，32570680，2026/01-2029/12（主持）

2.国家自然科学基金面上项目，32270620，2023/01-2026/12（主持）

3.国家自然科学基金面上项目，31972883，2020/01-2023/12（主持）

4.浙江省自然科学基金/重点项目，LZ23C060001，RNA修饰介导双酚A替代物暴露所致早期发育缺陷的机制研究，2023/01-2025/12（主持）

5.科技部国家重点研发计划，2022YFC2704200，卵巢癌发生机制及精准防治，2022/01-2025/12（项目骨干）

6.科技部国家重点研发计划，2021YFC2700900，线粒体功能障碍导致出生缺陷的基因治疗临床前研究和产品研发，2021/08-2024/07（项目骨干）

7.浙江省重点研发计划，2019C03010，高发恶性肿瘤诊治新技术研究-基于关键问题导向的卵巢癌诊治新技术研究及应用，2019/01-2022/12（项目骨干）

实验室成员所获支持

1.国家自然科学基金青年项目（实验室博士后林介波）2026/01-2028/12

2.国家自然科学基金青年项目（实验室博士后王玲芳）2024/01-2026/12

3.中国博士后科学基金第76批面上资助（实验室博士后詹官凯）2024/12-2026/10

4.2024年度国家资助博士后研究人员计划（实验室博士后林介波）2024/09-2026/09

5.2024年度国家资助博士后研究人员计划（实验室博士后詹官凯）2024/09-2026/09

6.浙江省博士后择优资助项目特别资助（实验室博士后王玲芳）2023/12-2025/1

7.浙江省自然科学基金探索项目青年项目（实验室博士后王玲芳）2023/01-2025/12

竭诚欢迎对科研有兴趣的同伴加入

本实验室希望能培养出有想法、热情、实践力的科研工作者，并与其一同进行有趣而振奋人心的研究。欢迎博士后、研究生、和本科实习生来信讨论可能的研究主题与机会。

ORCiD: https://orcid.org/0000-0001-8071-0122

实验室成员

Hsu Laboratory - Lab Members

许志宏：课题组组长，ch_hsu@zju.edu.cn

博士后

林介波：11818198@zju.edu.cn

刘劲风：liujinfeng@zju.edu.cn

詹官凯：12018355@zju.edu.cn

研究生

苏昆卉：2023级博士研究生，22018049@zju.edu.cn

孙思齐：2025级博士研究生，siqi_sun@zju.edu.cn

黄伊琳：2025级博士研究生，842672655@qq.com

唐文斌：2023级硕士研究生，22318049@zju.edu.cn

王璐瑶: 2024级硕士研究生，littlewang@zju.edu.cn

黄若男: 2025级硕士研究生，1335986063@qq.com

其他成员

梁严文：交流生，yanwen95@zju.edu.cn

研究与成果

Selected Publications:

●Su K#, Lin J#, Chen J#, Wu H, Tang W, Sun S, Lin J, Zhan G, Hsu CH*. Bisphenol C Induces Cardiac Developmental Defects by Disrupting m6A Homeostasis.

Environmental Science & Technology. 2024 Oct 1;58(39):17259-17269.

● Lin J^#, Zhan G^#, Liu J^#, Maimaitiyiming Y, Deng Z, Li B, Su K, Chen J, Sun S, Zheng W, Yu X, He F, Cheng X, Wang L, Shen B, Yao Z, Yang X, Zhang J, He W, Wu H, Naranmandura H, Chang KJ, Min J, Ma J, B. Mikael, Xu P*, Wang F*, Hsu CH*. YTHDF2-mediated regulations bifurcate BHPF-induced programmed cell deaths.

National Science Review. 2023 https://doi.org/10.1093/nsr/nwad227

_*Correspondence

^★Highlighted by EurekAlert!

● Wang L^#, Zhan G^#, Maimaitiyiming Y^#, Su Y, Lin S, Liu J, Su K, Lin J, Shen S, He W, Wang F, Chen J, Sun S, Xue Y, Gu J, Chen X, Zhang J, Zhang L, Wang Q, Chang KJ, Chiou SH, Björklund M, Naranmandura H*, Cheng X*, Hsu CH*. m6A Modification Confers Thermal Vulnerability to HPV E7 Oncotranscripts via Reverse Regulation of its Reader Protein IGF2BP1 upon Heat Stress.

Cell Reports. 2022 Oct 25;41(4):111546.

_*Correspondence

^★Cover Article

● Chen S^#, Zhang L^#, Li M^#, Zhang Y^#, Sun M, Wang L, Lin J, Cui Y, Chen Q, Jin C, Li X, Wang B, Chen H, Zhou T*, Wang L*, Hsu CH*, Zhuo W*. Fusobacterium nucleatum Reduces METTL3-mediated m6A Modification and Contributes to Colorectal Cancer Metastasis.

Nature Communications. 2022 Mar 10;13(1):1248.

_*Correspondence

● Liu J^#, Lin J^#, Chen J^#, Maimaitiyiming Y, Su K, Sun S, Zhan G, Hsu CH*. Bisphenol C induces developmental defects in liver and intestine through mTOR signaling in zebrafish (Danio rerio).

Chemosphere. 2023 May;322:138195. doi: 10.1016/j.chemosphere.2023.138195.

_*Correspondence

● Maimaitiyiming Y^#, Yang T^#, Wang QQ^#, Feng Y, Chen Z, Björklund M, Wang F, Hu C*, Hsu CH*, Naranmandura H*. Heat Treatment Promotes Ubiquitin-Mediated Proteolysis of SARS-CoV-2 RNA Polymerase and Decreases Viral Load.

Research. 2022 Feb 23;2022:9802969.

_*Correspondence

● Maimaitiyiming Y^#, Wang QQ^#, Yang C, Ogra Y^#, Lou Y, Smith CA, Hussain L, Shao YM, Lin J, Liu J, Wang L, Zhu Y, Lou H, Huang Y, Li X, Chang KJ, Chen H, Li H, Huang Y, Tse E, Sun J, Bu N, Chiou SH, Zhang YF, Hua HY, Ma LY, Huang P, Ge MH, Cao FL, Cheng X, Sun H, Zhou J, Vasliou V, Xu P, Jin J, Björklund M, Zhu HH, Hsu CH*, Naranmandura H*. Hyperthermia Selectively Destabilizes Oncogenic Fusion Proteins.

Blood Cancer Discovery. 2021 May 11;2(4):388-401.

_*Correspondence

^★Commented in: 'IN THE SPOTLIGHT' PML/RARA destabilization by hyperthermia: a new model for oncogenic fusion protein degradation?

Blood Cancer Discovery: 2021 Jun 10;2(4):300-301.

● Xiang Y^#, Laurent B^#, Hsu CH^#, Nachtergaele S, Lu Z, Xu C, Sheng W, Chen H, Jian O, Wang S, Ling D, Hsu PH, Zou L, Jambhekar A, He C, Shi Y. RNA m6A methylation regulates the ultraviolet-induced DNA damage response.

Nature. 2017 Mar 23;543(7646):573-576.

^#Co-first author. The order of three first authors was determined by a roll of the dice.

^★Commented in:

Nature Reviews Molecular Cell Biology: RESEARCH HIGHLIGHT. 2017 May;18(5):277.

Cancer Discovery: Research Watch. DOI: 10.1158/2159-8290.CD-RW2017-058.

Science Signaling: EDITORS' CHOICE. DOI: 10.1126/scisignal.aan2960.

F1000Prime: Article Recommendations.

● Huang Y^#, Yu SH^#, Zhen WX, Cheng T, Wang D, Lin JB, Wu YH, Wang YF, Chen Y, Shu LP, Wang Y, Sun XJ, Zhou Y, Yang F*, Hsu CH*, Xu PF*. Tanshinone I, a new EZH2 inhibitor restricts normal and malignant hematopoiesis through upregulation of MMP9 and ABCG2.

Theranostics. 2021 May 8;11(14):6891-6904.

_*Correspondence

^★“The Top 50 High Impact Research of Traditional Medicine" in 2021. This selection was organized by the Journal of Acupuncture and Herbal Medicine with the support of the China Association of Traditional Chinese Medicine announced on April 11, 2023.

● Chen HY, Wang ML, Laurent B, Hsu CH*, Chen MT, Lin LT, Shen J, Chang WC, Hsu J, Chen YW, Huang PI, Li CP, Ma HI, Yang YP, Hung MC, Chen CH, Lin WC, Chiou SH*. Musashi-1 promotes stress-induced tumor progression through recruitment of AGO2.

Theranostics. 2020 Jan 1;10(1):201-217.

_*Correspondence

● Tsai PH^#, Chien Y^#, Wang ML^#, Hsu CH^#, Laurent B^#, Chou SJ, Chang WC, Chien CS, Li HY, Lee HC, Huo TI^#, Hung JH^#, Chen CH, Chiou SH. Ash2l interacts with Oct4-stemness circuitry to promote super-enhancer-driven pluripotency network.

Nucleic Acids Research. 2019 Nov 4;47(19):10115-10133.

^#Co-first author

● Zhang J, Lee YR, Dang F, Gan W, Menon AV, Katon JM, Hsu CH, Asara JM, Tibarewal P, Leslie NR, Shi Y, Pandolfi PP, Wei W. PTEN Methylation by NSD2 Controls Cellular Sensitivity to DNA Damage.

Cancer Discovery. 2019 Sep;9(9):1306-1323.

● Lee YR, Chen M, Lee JD, Zhang J, Lin SY, Fu TM, Chen H, Ishikawa T, Chiang SY, Katon J, Zhang Y, Shulga YV, Bester AC, Fung J, Monteleone E, Wan L, Shen C, Hsu CH, Papa A, Clohessy JG, Teruya-Feldstein J, Jain S, Wu H, Matesic L, Chen RH, Wei W, Pandolfi PP. Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway.

Science. 2019 May 17;364(6441).

^★Commented in:

Science: PERSPECTIVE，Restoring tumor suppression. DOI: 10.1126/science.aax5526.

Cancer Discovery: Research Watch. DOI: DOI: 10.1158/2159-8290.CD-RW2019-080.

F1000Prime: Article Recommendations.

● Greer EL, Blanco MA, Gu L, Sendinc E, Liu J, Aristizábal-Corrales D, Hsu CH, Aravind L, He C, Shi Y. DNA Methylation on N6-Adenine in C. elegans.

Cell. 2015 May 7; 161(4):868-78.

^★Cover Article

^★Previewed in: An Adenine Code for DNA: A Second Life for N6-Methyladenine.

Cell. 2015 May 7; 161(4):710-3.

● Hsu CH^#, Peng KL^#, Kang ML, Chen YR, Yang YC, Tsai CH, Chu CS, Jeng YM, Chen YT, Lin FM, Huang HD, Lu YY, Teng YC, Lin ST, Lin RK, Tang FM, Lee SB, Hsu HM, Yu JC, Hsiao PW, Juan LJ. TET1 suppresses cancer invasion by activating the tissue inhibitors of metalloproteinases.

Cell Reports. 2012 Sep 27; 2:(3):568–79.

^★Highlighted at Cell homepage from 14 to 27 September, 2012

^★Highlighted at Cell Reports homepage from 27 September to 25 October, 2012

^★Selected into Cell Reports Best of 2012.

^★Commented in Nature Reviews Cancer: RESEARCH HIGHLIGHT. 2012 Nov;12(11):738-9.

^#Co-first author

● Hsu CH, Peng KL, Jhang HC, Lin CH, Wu SY, Chiang CM, Lee SC, Yu WC, Juan LJ. The HPV E6 oncoprotein targets histone methyltransferases for modulating specific gene transcription.

Oncogene. 2012 May 3;31(18):2335-49.

● Hsu CH, Chang MD, Tai KY, Yang YT, Wang PS, Chen CJ, Wang YH, Lee SC, Wu CW, Juan LJ. HCMV IE2-mediated inhibition of HAT activity downregulates p53 function.

EMBO Journal. 2004 Jun 2;23(11):2269-80.

Invited Review & Chapter:

● Zhan G#, Liu J#, Lin J#, Chen J, Sun S, Maimaitiyiming Y*, Hsu CH*. Multifaceted Functions of RNA m6A Modification in Modulating Regulated Cell Death.

RNA Structure and Function. 2023. 539–573.

● Su Y^#,Maimaitiyiming Y^#, Wang L^#, Cheng X*, Hsu CH*. Modulation of Phase Separation by RNA: A Glimpse on N6-Methyladenosine Modification.

Front. Cell Dev. Biol. 2021 Dec 10;9:786454. DOI: https://doi.org/10.3389/fcell.2021.786454.

_*Correspondence

● Wang L^#, Maimaitiyiming Y^#, Su K^#, Hsu CH*. RNA m6A Modification: A Mediator between Cellular Stresses and Biological Effects.

Epitranscriptomics. 2021 July pp 353-390.

_*Correspondence

● Maimaitiyiming Y, Wang QQ, Hsu CH*, Naranmandura H*. Arsenic induced epigenetic changes and relevance to treatment of acute promyelocytic leukemia and beyond.

Toxicol Appl Pharmacol. 2020 Nov 1;406:115212.

_*Correspondence

● Liang Y^#, Zhan G^#, Chang KJ, Yang YP, Wang L, Lin J, Hsu CH*. The roles of m6A RNA modifiers in human cancer.

J Chin Med Assoc. 2020 Mar;83(3):221-226.

_*Correspondence

Other Publications:

● Li Z^#, Xu H^#, Li J^#, Xu X^#, Wang J, Wu D, Zhang J, Liu J, Xue Z, Zhan G, Tan BCP, Chen D, Chan YS, Ng HH, Liu W, Hsu CH, Zhang D*, Shen Y*, Liang H*. Selective binding of retrotransposons by ZFP352 facilitates the timely dissolution of totipotency network.

Nature Communications. 2023 Jun 20;14(1):3646.

● Chen HY, Lin LT, Wang ML, Laurent B, Hsu CH, Pan CM, Jiang WR, Chen PY, Ma HI, Chen YW, Huang PI, Chiou A, Chiou SH. Musashi-1 Enhances Glioblastoma Cell Migration and Cytoskeletal Dynamics through Translational Inhibition of Tensin3.

Sci Rep. 2017 Aug 18;7(1):8710.

● Teng YC, Lee CF, Li YS, Chen YR, Hsiao PW, Chan MY, Lin FM, Huang HD, Chen YT, Jeng YM, Hsu CH, Yan Q, Tsai MD, Juan LJ. Histone Demethylase RBP2 Promotes Lung Tumorigenesis and Cancer Metastasis.

Cancer Research. 2013 Aug 1;73(15):4711-4721.

● Tyan SW, Hsu CH, Peng KL, Chen CC, Kuo WH, Lee EY, Shew JY, Chang KJ, Juan LJ, Lee WH. Breast cancer cells induce stromal fibroblasts to secrete ADAMTS1 for cancer invasion through an epigenetic change.

PLoS ONE. 2012 Apr 13;7(4):e35128.

● Chiou SH, Yang YP, Lin JC, Hsu CH, Jhang HC, Yang YT, Lee CH, Ho LL, Hsu WM, Ku HH, Chen SJ, Chen SS, Chang MD, Wu CW, Juan LJ. The immediate early 2 protein of human cytomegalovirus mediates the apoptotic control in HCMV retinitis through upregulation of the cellular FLICE-inhibitory protein expression.

The Journal of Immunology. 2006 Nov 1;177(9):6199-206.